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| 1 | Pyogenic liver abscess: Changing patterns in approach显示文摘AIM: To define optimum management of the pyogenic liver abscess and assess new trends in treatment. METHODS: One hundred and sixty nine patients with pyogenic liver abscess managed at Sher-i-Kashmir In- stitute of Medical Sciences, Srinagar, Kashmir (India) from July 2001 to August 2006 were studied to evaluate and define the optimum treatment. RESULTS: Mortality in the surgically treated group of patients was 9.4% (12/119), while those treated non-surgically had a fatality rate of 16.66% (7/42). Multiple liver abscesses treated surgically had a surprisingly low mortality of 30%. The biliary tract (64.97%) was the most common cause of liver abscess. Multiple abscesses, mixed organisms and abscess complications are all associated with a significantly increased mortality. However, the lethality of the primary disease process was the most important factor in determining survival.CONCLUSION: Transperitoneal surgical drainage and antibiotics are the mainstay of treatment. Percutaneous drainage is recommended for high risk patients only. | Ajaz A Malik Shams UL Bari Khawaja Abdul Rouf Khurshid Alam Wani | 2010 | World Journal of Gastrointestinal Surgery2010，2，12： | 15 |
| 2 | Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM: To critically appraise the published randomized, controlled trials on the prophylactic effectiveness of the non-steroidal anti-inflammatory drugs(NSAIDs), in reducing the risk of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis. METHODS: A systematic literature search(MEDLINE, Embase and the Cochrane Library, from inception of the databases until May 2015) was conducted to identify randomized, clinical trials investigating the role of NSAIDs in reducing the risk of post-ERCP pancreatitis. Random effects model of the meta-analysis was carried out, and results were presented as odds ratios(OR) with corresponding 95%CI.RESULTS: Thirteen randomized controlled trials on 3378 patients were included in the final meta-analysis. There were 1718 patients in the NSAIDs group and 1660 patients in non-NSAIDs group undergoing ERCP. The use of NSAIDs(through rectal route or intramuscular route) was associated with the reduced risk of post-ERCP pancreatitis [OR, 0.52(0.38-0.72), P = 0.0001]. The use of pre-procedure NSAIDs was effective in reducing approximately 48% incidence of post-ERCP pancreatitis, number needed to treat were 16 with absolute risk reduction of 0.05. But the risk of post-ERCP pancreattis was reduced by 55% if NSAIDs were administered after procedure. Similarly, diclofenac was more effective(55%) prophylactic agent compared to indomethacin(41%).CONCLUSION: NSAIDs seem to have clinically proven advantage of reducing the risk of post-ERCP pancreatitis. | Muhammad S Sajid Amir H Khawaja Mazin Sayegh Krishna K Singh Zinu Philipose | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 14 |
| 3 | GPS/INU/DM组合定位导航技术在ITS中的应用显示文摘介绍了智能交通系统 (ITS ,IntelligentTransportSystems)的基本思想 ,阐述了GPS/INU/DM (GlobalPositioningSystem/InertialNavigationUnit/DigitalMap)组合定位导航技术在ITS中的应用 ,以及提高组合定位导航精度及可靠性的几种技术措施 .该组合定位导航是将卫星定位技术、惯性导航定位技术以及计算机技术融合在一起的新型技术 ,具有全方位、全天候、防遮挡的功能 .ITS中利用组合导航技术可实现道路交通管理“自动化”、车辆行驶“智能化” ,具有良好的实用价值 ,应用前景广泛 . | 张飞舟 Basharat Mahmood Khawaja 范跃祖 孙先仿 | 2000 | 北京航空航天大学学报2000，26，3： | 13 |
| 4 | Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: The role of inflammatory biomarkers显示文摘Pneumonia and acute respiratory distress syndrome are common and important causes of respiratory failure in the intensive care unit with a significant impact on morbidity, mortality and health care utilization despite early antimicrobial therapy and lung protective mechanical ventilation. Both clinical entities are characterized by acute pulmonary inflammation in response to direct or indirect lung injury. Adjunct anti-inflammatory treatment with corticosteroids is increasingly used, although the evidence for benefit is limited. The treatment decisions are based on radiographic, clinical and physiological variables without regards to inflammatory state. Current evidence suggests a role of biomarkers for the assessment of severity, and distinguishing sub-phenotypes (hyperinflammatory versus hypo-inflammatory) with important prognostic and therapeutic implications. Although many inflammatory biomarkers have been studied the most common and of interest are C-reactive protein, procalcitonin, and pro-inflammatory cytokines including interleukin 6. While extensively studied as prognostic tools (prognostic enrichment), limited data are available for the role of biomarkers in determining appropriate initiation, timing and dosing of adjunct anti-inflammatory treatment (predictive enrichment) | Sarah Chalmers Ali Khawaja Patrick M Wieruszewski Ognjen Gajic Yewande Odeyemi | 2019 | World Journal of Critical Care Medicine2019，8，5： | 12 |
| 5 | Acquired pMHC I Complexes Greatly Enhance CD4^+ Th Cell's Stimulatory Effect on CD8^+ T Cell-Mediated Diabetes in Transgenic RIP-mOVA Mice显示文摘CD4+ helper T (Th) cells play pivotal roles in induction of CD8+ CTL immunity. However, the mechanism of CD4+ T cell help delivery to CD8+ T cells in vivo is still elusive. In this study, we used ovalbumin (OVA)-pulsed dendritic cells (DCOVA) to activate OT-II mouse CD4+ T cells, and then studied the help effect of these CD4+ T cells on CD8+ cytotoxic T lymphocyte (CTL) responses. We also examined CTL mediated islet β cell destruction which led to diabetes in wild-type C57BL/6 mice and transgenic rat insulin promoter (RIP)-mOVA mice expressing β cell antigen OVA with self OVA-specific tolerance, respectively. In adoptive transfer experiments, we demonstrated that help, in the form of peptide/major histocompatibility complex (pMHC) I acquired from DCOVA by DCOVA activation, was required for induction of OVA-specific CTL responses in C57BL/6 mice. However, in combination with TCR transgenic OT-I mouse CD8+ T cells, the tolerogenic dosage of CD4+ Th cells with acquired pMHC I, but not CD4+ (Kb-/-) Th cells without acquired pMHC I were able to cause diabetes in 8/10 (80%) RIP-mOVA mice. This study thus expands the current knowledge in T cell-mediated autoimmunity and provides insight into the nature of CD4+ T cell-mediated help in CD8+ CTL induction. | Khawaja Ashfaque Ahmed Yufeng Xie Xueshu Zhang Jim Xiang | 2008 | Cellular & Molecular Immunology2008，5，6： | 6 |
| 6 | Intercellular Trogocytosis Plays an Important Role in Modulation of Immune Responses显示文摘Intercellular communication is an important means of molecular information transfer through exchange of membrane proteins from cells to cells. Advent of the latest analytical and imaging tools has allowed us to enhance our understanding of the cellular communication through the intercellular exchange of intact membrane patches,also called trogocytosis,which is a ubiquitous phenomenon. Immune responses against pathogens or any foreign antigens require fine immune regulation,where cellular communications are mediated by either soluble or cell surface molecules. It has been demonstrated that the membrane molecule transfer between immune cells such as dendritic and T cells can be derived through internalization/recycling pathway,dissociation-associated pathway,uptake of exosomes and membrane nanotube formations. Recent evidence implicates the trogocytosis as an important mechanism of the immune system to modulate immune responses. Exchange of membrane molecules/ antigens between immune cells has been observed for a long time,but the mechanisms and functional consequences of these transfers remain unclear. In this review,we discuss the possible mechanisms of trogocytosis and its physiological relevance to immune system,with special reference to T cells and the stimulatory or suppressive immune responses derived from T cells with acquired dendritic cell membrane molecules. | Khawaja Ashfaque Ahmed Manjunatha Ankathatti Munegowda Jim Xiang | 2008 | Cellular & Molecular Immunology2008，5，4： | 6 |
| 7 | Sound waves in fluidized bed using CFD-DEM simulations显示文摘 | Hassan Abbas Khawaja | 2018 | Particuology2018，16，3： | 4 |
| 8 | 黏土稳定剂在石油行业的应用进展显示文摘在油田开发的过程中时常会遇到黏土矿物的水化膨胀及分散运移,引起储层的堵塞进而损害储层。国内外学者研发了许多的黏土稳定剂来尽量避免这种情况的发生。随着油气资源向深层、高温、裂缝及低渗发展,大多数黏土稳定剂已无法满足复杂地层下的开发的要求。因此,黏土稳定剂也就成为了重要的研究课题。将黏土稳定剂按照应用领域划分为3类:油田勘探用黏土稳定剂、油田开发用黏土稳定剂和油田维护用黏土稳定剂,并综述了各个领域黏土稳定剂的发展现状、进展和发展趋势及相应的评估和建议。 | 宋洪瑞 李东胜 杨双春 蔡家铁 李敏 Khawaja Haris Mir | 2021 | 应用化工2021，50，5： | 4 |
| 9 | Comparative Study on Structural Redundancy of Cable-Stayed and Extradosed Bridges Through Safety Assessment of Their Stay Cables显示文摘This study provides new insights into the comparison of cable-stayed and extradosed bridges based on the safety assessment of their stay cables.These bridges are often regarded as identical structures owing to the use of inclined cables;however,the international standards for bridge design stipulate different safety factors for stay cables of both types of bridges.To address this misconception,a comparative study was carried out on the safety factors of stay cables under fatigue and ultimate limit states by considering the effects of various untoward and damaging factors,such as overloading,cable loss,and corrosion.The primary goal of this study is to describe the structural disparities between both types of bridges and evaluate their structural redundancies by employing deterministic and nondeterministic methods.To achieve this goal,three-dimensional finite-element models of both bridges were developed based on the current design guidelines for stay cables in Japan.After the balanced states of the bridge models were achieved,static analyses were performed for different safety factors of stay cables in a parametric manner.Finally,the first-order reliability method and Monte Carlo method were applied to determine the reliability index of stay cables.The analysis results show that cable-stayed and extradosed bridges exhibit different structural redundancies for different safety factors under the same loading conditions.Moreover,a significant increase in structural redundancy occurs with an incremental increase in the safety factors of stay cables. | Khawaja Ali Hiroshi Katsuchi Hitoshi Yamada | 2021 | Engineering2021，7，1： | 4 |
| 10 | Recurrence of lymphangioleiomyomatosis: Nine years after a bilateral lung transplantation显示文摘Lymphangioleiomyomatosis(LAM) is a rare, slowly progressive lethal lung disease primary afflicting young women. LAM is characterized by proliferation of abnormal smooth muscle cells that target the lungs, causing cystic destruction and eventual respiratory failure leading to death. Recent ten year mortality due to end stage LAM has been reported to be approximately 10%-20%, but may vary. The decline in lung function in LAM is gradual, occurring at a rate of about 3% to 15% per year but can vary from patient to patient. But recently therapy with mammalian target of rapamycin(m TOR) inhibitors such as sirolimus has shown promising results in the stabilization of lung function and reduction of chylous effusions in LAM. Lung transplantation is a viable option for patients who continue to have decline in lung function despite m TOR therapy. Unique issues that may occur post-transplant in a recipient with LAM include development of chylous effusion and a risk of recurrence. We describe a case of LAM recurrence in a bilateral lung transplant recipient who developed histological findings of LAM nine years after transplantation. | Khawaja S Zaki Zahra Aryan Atul C Mehta Olufemi Akindipe Marie Budev | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 11 | Synthesis, Crystal Structure and Antimicrobial Activity of Ethyl 2-(1-cyclohexyl-4-phenyl-1H-1,2,3-triazol-5-yl)-2-oxoacetate显示文摘A novel 1,4,5-trisubstituted 1,2,3-triazole(C18H21N3O3) was synthesized by a one-pot three component reaction of 1-azidocyclohexane, 1-copper(I) phenylethyne and ethoxalyl chloride at room temperature. The molecular structure was determined by single-crystal X-ray analysis. The compound crystallizes in the monoclinic system, space group P21/n with a = 12.8167(9), b = 8.0966(6), c = 16.7079(9) , β = 98.716(2)o, Z = 4 and V = 1713.8(2). In the crystal, the molecules are related by inversion and paired into dimers via C–H···O and C–O···C interactions involving(oxo) acetate groups. Furthermore, X-ray analysis results are compared with the optimized structure computed by using B3 LYP method with 6-311 G basis set. The calculated results showed that optimized geometry can well reproduce the crystal structure parameters. The bioassay results indicate that the compound has good antibacterial and antifungal activities. | MUHAMMAD Naeem Ahmed SHAHID Hameed KHAWAJA Ansar Yasin IFZAN Arshad IHSAN-ul-Haq SAFEENA Zafar MUHAMMAD Nawaz Tahir | 2014 | Chinese Journal of Structural Chemistry2014，33，11： | 3 |
| 12 | The Association between Time Spent Outdoors and Myopia in Children and Adolescents显示文摘 | Justin C. Sherwin Mark H. Reacher Ruth H. Keogh Anthony P. Khawaja David A. Mackey Paul J. Foster | 2012 | Ophthalmology2012，，10： | 2 |
| 13 | One-pot Synthesis,Crystal Structures and Antimicrobial Activities of Two New 1,4-Disubstituted 1,2,3-Triazole-4-Carboxylates显示文摘Two new 1,4-disubstituted 1,2,3-triazoles-4-carboxylates were synthesized via click reaction. Compound 1a was synthesized by the interaction of 6-nitro-tetrazolo[1.5-a]-pyridine with ethyl propynoate at room temperature in the presence of Cu(OAc)2 as a catalyst and THF as solvent. Compound 1b was also synthesized by the same manner except that tert-butyl propionate, instead of ethyl propynoate, was used. The compounds were characterized by IR, 1H-NMR, 13C-NMR and single-crystal X-ray diffraction analysis. Compound 1a(C10H9N5O4) crystallizes in the triclinic system, space group P1 with a = 5.0894(9), b = 8.9834(13), c = 13.089(2) ?, α= 83.041(7), β= 80.256(7), γ=87.296(8)°, V = 585.24(16)?3, Z = 2, Mr = 263.22, crystal size(mm) = 0.37 × 0.20 ×0.18,(I > 2σ(I)) = 8557, 2493, 1229, Rint = 0.057. Compound 1b(C12H13N5O4) crystallizes in the monoclinic system, space group P21/c with a = 6.8854(5), b = 21.783(2), c = 9.3986(8) ?,β = 93.239(4)°, V = 1407.4(2)?3, Z = 4, Mr = 291.27, crystal size(mm) = 0.38 × 0.22 × 0.20,(I > 2σ(I)) = 11842, 3172, 1866, Rint = 0.047. Antimicrobial assay results showed that the title compounds display excellent activities to different bacterial and fungal strains. | MUHAMMAD Naeem Ahmed KHAWAJA Ansar Yasin MUHAMMAD Nawaz Tahir IFZAN Arshad MURTAZA Madni | 2015 | Chinese Journal of Structural Chemistry2015，34，1： | 2 |
| 14 | Semirigid Ureteroscopy and Pneumatic Lithotripsy as Definitive Management of Obstructive Ureteral Calculi During Pregnancy显示文摘 | Abdul Majid Rana Shahid Aquil Adnan Munir Khawaja | 2009 | Urology2009，，5： | 2 |
| 15 | Environmental pollution due to tanneries and leather manufacturing units in NWFP显示文摘 | Khawaja M A Jan M R Ahmed I 1995 | 1995 | J Anal & Envl Chem1995，3，1： | 1 |
| 16 | Prevalence and prognostic signifiance of heart failure stages: Application of the American college of cardiology/American heart association heart failure staging criteria in the community 显示文摘 | Khawaja AA Steven JJ Douglas | 2007 | Circulation2007，115，： | 1 |
| 17 | An impending cancer crisis in developing countries: are we ready for the cha- llenge ? 显示文摘 | Rehman MU Buttar QM Khawaja MI | 2009 | Asian Pac J Cancer Prev2009，10，4： | 1 |
| 18 | Problem-based versus con-ventional curricula:influence on knowledge and attitudes of medical students towards health research显示文摘 | Khan H Taqui AM Khawaja MR et al | 2007 | PLoS One2007，2，7： | 1 |
| 19 | Clinical profile and outconms of paediatric patients with diabetic ketoacidosis at a tertiary care ho6pital in Pakista显示文摘 | Syed M Khawaja FB Saleem T et at | 2011 | J Pak Med Assoc2011，61，11： | 1 |
| 20 | Beyond patient reported pain:perfusion magnetic resonance imaging demonstrates reproducible cerebral representation of ongoing postsurgical pain显示文摘 | Howard MA Krause K Khawaja N | | 0，，： | 1 |
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