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| 1 | 有低频残余听力感音神经聋的人工耳蜗植入术显示文摘目的介绍一种有低频残余听力感音神经聋的人工耳蜗植入技术,探讨人工耳蜗植入手术对有残余听力患者的治疗效果和价值。方法15例有残余听力的患者接受了保护残余听力的人工耳蜗植入手术。术中电极植入深度在19mm~24mm左右。术后分别检测单纯使用助听器、单纯使用人工耳蜗、人工耳蜗结合助听器三种不同状态下的听力。结果15例患者中,有13例术后残余听力保存良好,仅分别丢失5~20dB听力,但另2例术后残余听力全部丧失。术后在安静、信噪比15dB和10dB三种不同状态下的言语测试结果显示,人工耳蜗结合助听器使用者测试得分始终保持在很高水平;单纯使用人工耳蜗者也有较好的成绩,但在信噪比达10dB的条件下,测试成绩下降;而单纯使用助听器者,不仅在安静状态下听力成绩不甚理想,一旦加入竞争性噪声,听力测试成绩急剧下降。结论保护和利用残余听力的人工耳蜗植入技术,使人工耳蜗植入手术对象从重度或极重度聋扩大到高频为重度或极重度聋,低频(≤500Hz)为中、轻度聋的患者。接受这项技术患者的听力和言语识别能力均明显优于其单纯配戴助听器和单纯使用人工耳蜗时的听力和言语识别能力。 | 叶青 Jan Kiefer 杨仕明 | 2009 | 中华耳科学杂志2009，7，3： | 12 |
| 2 | Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells显示文摘免疫球蛋白 E (IgE ) 在过敏气喘起一个关键作用并且是为 monoclonal 抗体的一个临床上验证的目标。治疗学的 anti-IgE 抗体块在 IgE 和 Fc epsilon 之间的相互作用(Fcε) 受体,它消除或最小化,但是做过敏显型不典型地由 B 房间削减 IgE 的进行中的生产。我们产生了有潜力抵销可溶的 IgE 并且通过抗体依赖者消除表示 IgE B 房间的高亲密关系的 anti-IgE 抗体(MEDI4212 ) 调停房间的 cytotoxicity。MEDI4212 变体被产生在 fucosylation 在抗体或改变的 Fc 区域包含变化以便为 Fcγ 提高抗体亲密关系; RIIIa。所有 MEDI4212 变体与比得上的亲密关系跳了到人的 IgE 野类型(WT ) 抗体。每变体被显示禁止在 IgE 和 Fcε 之间的相互作用; RI,它翻译了成 Fcγ 的有势力抑制;调停 RI 的功能回答。重要地,所有变体在表示房间的膜 IgE 的表面同样跳了到 IgE。然而, MEDI4212 变体为 Fcγ 表明了提高的亲密关系;包括在位置 158 点的多态的变体的 RIIIa。在 Fcγ 的改进;导致的 RIIIa 绑定在用两个都设计的房间线和类的基于的试金交换了的房间增加了受动器功能人的 IgE B 房间。通过它 IgE 的优异抑制,我们预计那受动器功能提高了 MEDI4212 也许能抵销可溶的 IgE 的高水平并且在他们区分并且变得 IgE secreting 血浆房间以前,由消除表示 B 房间的 IgE 提供增加的长期的利益。 | Andrew C. Nyborg Anna Zacco Rachel Ettinger M. Jack Borrok Jie Zhu Tom Martini Rob Woods Christine Kiefer Michael A. Bowen E. Suzanne Cohenz Ronald Herbst Herren Wu Steven Coats | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 3 | Prediction of rockhead using a hybrid N-XGBoost machine learning framework显示文摘The spatial information of rockhead is crucial for the design and construction of tunneling or underground excavation.Although the conventional site investigation methods(i.e.borehole drilling) could provide local engineering geological information,the accurate prediction of the rockhead position with limited borehole data is still challenging due to its spatial variation and great uncertainties involved.With the development of computer science,machine learning(ML) has been proved to be a promising way to avoid subjective judgments by human beings and to establish complex relationships with mega data automatically.However,few studies have been reported on the adoption of ML models for the prediction of the rockhead position.In this paper,we proposed a robust probabilistic ML model for predicting the rockhead distribution using the spatial geographic information.The framework of the natural gradient boosting(NGBoost) algorithm combined with the extreme gradient boosting(XGBoost)is used as the basic learner.The XGBoost model was also compared with some other ML models such as the gradient boosting regression tree(GBRT),the light gradient boosting machine(LightGBM),the multivariate linear regression(MLR),the artificial neural network(ANN),and the support vector machine(SVM).The results demonstrate that the XGBoost algorithm,the core algorithm of the probabilistic NXGBoost model,outperformed the other conventional ML models with a coefficient of determination(R2)of 0.89 and a root mean squared error(RMSE) of 5.8 m for the prediction of rockhead position based on limited borehole data.The probabilistic N-XGBoost model not only achieved a higher prediction accuracy,but also provided a predictive estimation of the uncertainty.Thus,the proposed N-XGBoost probabilistic model has the potential to be used as a reliable and effective ML algorithm for the prediction of rockhead position in rock and geotechnical engineering. | Xing Zhu Jian Chu Kangda Wang Shifan Wu Wei Yan Kiefer Chiam | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，6： | 3 |
| 4 | Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique显示文摘 | Melanie Bruegel Konstantin Holzapfel Jochen Gaa Klaus Woertler Simone Waldt Berthold Kiefer Alto Stemmer Carl Ganter Ernst J. Rummeny | 2008 | European Radiology2008，，： | 2 |
| 5 | 瑞士驻沪总领事馆和德国驻上海总领事馆文化教育处的室内空间显示文摘瑞士总领事馆和德国驻沪领事馆文化教育处两个项目由上海意迅装饰设计工程有限公司(Shanghai laction Decoration Design & Engineering Co.Ltd. )的建筑设计师Pirjo kiefer设计。两个项目的并置,可以看到设计师在处理室内不同吊顶高度条件限制情况下的不同设计方法。 | Pirjo Kiefer 张晓春 | 2003 | 时代建筑2003，46，6： | 2 |
| 6 | Chlorophyll a fluorescence in marine centric diatoms: Responses of chloroplasts to light and nutrient stress显示文摘 | D. A. Kiefer | 1973 | Marine Biology1973，，1： | 2 |
| 7 | Determination of absorption and fluorescence excitation spectra for phytoplankton 显示文摘 | Mitchell B G and D A Kiefer | 1984 | Marine phytoplankton and productivity1984，8，： | 2 |
| 8 | The N400 is modulated by unconsciously perceived masked words: further evidence for an automatic spreading activation account of N400 priming effects 显示文摘 | Kiefer M | 2002 | Cognitive Brain Research2002，13，1： | 1 |
| 9 | Gamma interferon like immunoreactivity in the rat nervous system显示文摘 | Kiefer R Keutzberg G W | 1990 | Neurosci1990，37，3： | 1 |
| 10 | Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A显示文摘 | Kiefer C Hessel S Lampert J M etal | 2001 | Journal of Biological Chemistry2001，17，14： | 1 |
| 11 | Differential endogenous pain modulation in complex-regional pain syndrome 显示文摘 | Seifert F Kiefer G DeCol R | 2009 | Brain2009，132，3： | 1 |
| 12 | Liquidity information, and less-frequently traded stocks 显示文摘 | EASLEY D KIEFER N M HARA M O' | 1996 | Journal of Finance1996，51，： | 1 |
| 13 | A simple and efficient protocol for isolation of functional RNA from plant tissues rich in secondary metabolites显示文摘 | Evi Kiefer Werner Heller Dieter Ernst | 2000 | Plant Molecular Biology Reporter2000，，1： | 1 |
| 14 | The SWISS-MODEL repository and associated resources显示文摘 | Kiefer F Arnold K Künzli M | 2009 | Nucleic Acids Res2009，37，： | 1 |
| 15 | A review of 12 commonly used medicinal herbs 显示文摘 | O'Hara M Kiefer D Farrell K | 1998 | Arch Faro Med1998，7，6： | 1 |
| 16 | Theuse of intensity-hue-saturation transformations formerging SPOT pnchromatic and multispectral imagedata显示文摘 | CARPER W J LILLESAND T M KIEFER R W | 1990 | Photogammetric Engineering and RemoteSensing1990，56，5： | 1 |
| 17 | Gamma interferon-like immunoreactivity in the rat nervous system显示文摘 | Kiefer R Keutzberg G W | 1990 | Neurosc-i1990，35，3： | 1 |
| 18 | The SWISS-MODEL repos- itory and associated resources 显示文摘 | Kiefer F Arnold K Kunzli M | 2009 | Nucleic Acids Research2009，37，： | 1 |
| 19 | The role of action representation in visual object显示文摘 | Helbig H B Graf M Kiefer M | | 0，，： | 1 |
| 20 | Genome and tran-scriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities显示文摘 | Craig DW O'Shaughnessy JA Kiefer JA | | 0，，01： | 1 |
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