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| 1 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 2 | Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer显示文摘 | Grote H J Schmiemann V Kiel S | 2004 | Int J Cancer2004，110，5： | 1 |
| 3 | The human metapneumovirus:a case series and review of the literature显示文摘 | Shahda S Carlos WG Kiel PJ | | 0，，： | 1 |
| 4 | Uncertainty in the niches that maintain haematopoietic stem cells显示文摘 | Kiel M J Morrison S J | 2008 | Nat Rev Immunol2008，8，4： | 1 |
| 5 | Glucose-related dissociation between ica ADBC transcription and biofilm expression by Staphylococcus epidermidis:evidence for an additional factor required for polysaccharide intercellular adhesin synthesis显示文摘 | Dobinsky S Kiel K Rohde H | 2003 | J Bacteriol2003，185，9： | 1 |
| 6 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 7 | Comparison of weekly treat- ment of postmenopansal osteoporosis with alendronate versus risedronate over two years显示文摘 | Bonnick S Saag KG Kiel DP | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
| 8 | Comparison of postmenopausal osteoporosis with alendronate versus rise dronate over two years显示文摘 | Bonnick S Saag KG Kiel DP | 2006 | Clin Endocrinol Melab2006，91，7： | 1 |
| 9 | The role of p63 and dehaNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis 显示文摘 | Geddert H Kiel S Heep HJ | 2003 | Hum Pathol2003，34，9： | 1 |
| 10 | Comparison of postmenopausal osteoporosis with alendronate versus risedronate over two years 显示文摘 | Bonnick S Saag KG Kiel DP | 2006 | J Clin Endocrinol Melab2006，91，7： | 1 |
| 11 | Impact of mechanical disturbance on the emergence of Culicoides from cowpats 显示文摘 | Liihken R Kiel E Steinke S | 2014 | Parasitol Res2014，113，4： | 1 |
| 12 | Catalytic decomposition of biomass tars: Use of dolomite and untreated olivine显示文摘 | DEVI L PTASINSKI K J JANSSEN F J J G PAASEN S V B BERGMAN P C A KIEL J H A | 2005 | Renew Energy2005，30，4： | 1 |
| 13 | A Comparison of verified distance computation between implicit objects using different arithmetics for range enclosure 显示文摘 | Dyllong E Kiel S | 2012 | Computing (S 1436-5057)2012，94，24： | 1 |
| 14 | Glucose related dissociation between icaADBC transcription and biofilm espression by Staphylococcus epidermidis:evidence for an additional factor required for polysaccharide intercellular adhesin synt hesin显示文摘 | Kiel K Rohde H | 2003 | J Bacteriol2003，185，： | 1 |
| 15 | Polymorphisms in the PPAR gamma gene influence bone density in Humans 显示文摘 | Kiel DP Ferrari S Cupples LA | 2005 | J Bone Miner Res2005，20，： | 1 |
| 16 | Peripheral blood stem cell mobilization tactics 显示文摘 | ROSENBECK L L SRIVASTAVA S KIEL P J | 2010 | Ann Pharmacother2010，44，： | 1 |
| 17 | The role of p63 and deltaNp63 protein expression and gene amdification in,esophageal carcinogenesis显示文摘 | Gedded H Kiel S Heep HJ | 2003 | Hum Pathol2003，34，9： | 1 |
| 18 | PDGF alpha re- ceptor signal strength controls an RTK rheostat' that in- tegrates phosphoinositol 3'-kinase and phospholipase C gamma pathways during oligoden drocytematuration显示文摘 | Me Kinnon RD Waldron S Kiel ME | 2005 | J Neurosci2005，25，14： | 1 |
| 19 | Behaviour of iron-bearing minerals in the early stages of pulverised coal conversion processes 显示文摘 | VUTHALURU H B EENKHOORN S HAMBURG G HEERE P G T KIEL J H A | 1998 | Fuel Process Technol1998，56，12： | 1 |
| 20 | The human metapneumovirus:a case series and review of the literature显示文摘 | Shahda S Carlos WG Kiel PJ | 2011 | Transpl Infect Dis2011，13，3： | 1 |
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