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| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | 咽鼓管功能障碍定义、类型、临床表现及诊断的共识声明显示文摘1引言 英国NIHR卫生技术评估(HTA)计划发表的咽鼓管功能障碍治疗的系统回顾性研究指出,目前缺乏咽鼓管功能障碍统一的定义和诊断标准,推进这一领域研究进展的关键是针对咽鼓管功能障碍的诊断标准和重要临床结果达成共识。因此,2014年06月21日在荷兰阿姆斯特丹召开了由咽鼓管功能障碍领域的医学专家和科学家们参加的研讨会,旨在针对咽鼓管功能障碍的定义、临床表现、诊断及未来研究领域等方面达成共识。本文针对本次会议讨论结果总结如下。 | Schilder AG Bhutta MF Butler CC Holy C Levine LH Kvaerner KJ Norman G Pennings RJ Poe D Silvola JT Sudhoff H Lund VJ 翻曲腾飞 龚树生 | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，6： | 5 |
| 3 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 4 | Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study显示文摘We evaluated the efficacy and safety of gamma knife stereotactic radiosurgery(GKSR)followed by bevacizumab combined withchemotherapy in 11 patients with recurrent glioblastoma multiforme who experienced tumor progression despite aggressive | Park KJ Kano H Iyer A Liu X Niranjan A Flickinger JC Lieberman FS Lunsford LD Kondziolka D | 2012 | 中国神经肿瘤杂志2012，10，4： | 3 |
| 5 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 6 | Human Cardiotro- phin-1 : protein and gene structure, biological and binding ac- tivities, and chromosomal localization显示文摘 | Pennica D Swanson TA Shaw KJ | 1996 | Cytokine1996，8，3： | 1 |
| 7 | The tumor suppressor candidate p33ING1b mediates repair of UV-damaged DNA显示文摘 | Cheung KJ Mitchell D Lin P | 2001 | Cancer Res2001，61，： | 1 |
| 8 | Ropivacaine: an update of its use in regional anaesthia显示文摘 | MeClellan KJ Faulds D | 2000 | Druge2000，60，： | 1 |
| 9 | Combined aerobic heterotrophic oxidation nitrification and denitrification in a permeable-support biofilm显示文摘 | Timberlake D L Strand SE Williamson KJ | 1988 | Water Research1988，22，12： | 1 |
| 10 | Neuroendoscopic third ventriculostomy for hydrocephalus in adults: report of a single unit's experience with 63 cases 显示文摘 | Buxton N Ho KJ Macarthur D | 2001 | surg Neurol2001，55，2： | 1 |
| 11 | Diagnosing blunt hollow viscus injury显示文摘 | D'Andrea KJ Anastasia K | 2013 | Am J Surg2013，205，4： | 1 |
| 12 | Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placentaloxygenation in pregnant mice 显示文摘 | Kulandavelu S Whiteley KJ Qu D etal | 2012 | Hypertension2012，60，1： | 1 |
| 13 | Shifting players and paradigms in cell-specific transcription显示文摘 | D’Alessio JA Wright KJ Tjian R | 2009 | Mol Cell2009，36，6： | 1 |
| 14 | Determinants of the Middle Cerebral Artery Peak Systolic Velocity in the Human Fetus显示文摘 | Picklesimer AH Oepkes D Moise KJ | 2007 | Am J Obstetrics Gynecol2007，197，5： | 1 |
| 15 | Expression cloning o cardiotrophin 1, a cytokine that induces cardiac myocyte hy pertrophy显示文摘 | Pennica D King KL Shaw KJ | 1995 | Proc Natl Acad Sci USA1995，92，4： | 1 |
| 16 | Ropivacaine : An update of its use in regional anesthesia显示文摘 | Mc-Clellan KJ Faulds D | 2000 | Drugs2000，60，10： | 1 |
| 17 | Surgical treatmont of venous malformations in Klippel-Tronaunay syndromo 显示文摘 | Noel AA Gloviczki P Cherry KJ Jr et d | 2000 | J Vase Surg2000，32，5： | 1 |
| 18 | Preparation of bovine serum albumin loaded poly (D,L-lactic-co-glycolic acid) microspheres by a modified phase separation technique显示文摘 | Zhang JX Zhu KJ Chen D | 2005 | J Microencapsul2005，22，2： | 1 |
| 19 | Association of sleep apnea and type H diabetes:a population-basedstudy 显示文摘 | Reichmuth KJ Austin D Skatrucl JB | 2005 | Am J Respir CritCare Med2005，172，12： | 1 |
| 20 | Vibration sonoelastography and the detectability of lesions 显示文摘 | Parker KJ Fu D Graceswki SM | 1998 | Ultrasound in Medicine & Biology1998，24，9： | 1 |
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