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| 1 | Extraintestinal manifestations and complications in inflammatory bowel diseases显示文摘Crohn 的疾病(CD ) 和 ulcerative (UC ) 是经常包含胃肠道的除那些以外的机关的长期的煽动性的肠疾病(IBD ) 。这些非肠的爱被称为额外的肠的症状。把煽动性的肠疾病的真额外的肠的表明区分开来与第二等的额外的肠的复杂并发症,由治疗的营养不良,慢性炎或副作用引起了,可能困难。这评论在煽动性的肠疾病专注于频率,临床的演讲和额外的肠的症状的治疗学的含意。如果可能,肠的表明被区分开来与额外的肠的复杂并发症。特殊注意被给参与的更最近描述的地点;即中枢神经系统的 thromboembolic 事件,骨质疏松症,肺的参与和爱。 | Katja S Rothfuss Eduard F Stange Klaus R Herrlinger | 2006 | World Journal of Gastroenterology2006，12，30： | 26 |
| 2 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 3 | Diagnosis of obscure gastrointestinal bleeding by intraoperative enteroscopy in 81 consecutive patients显示文摘瞄准:为了由与流血调查一系列选择病人分析 intra 起作用的肠寄生物(IOE ) 的结果和复杂并发症,怀疑了从小肠发源。方法:81 个病人(吝啬的年龄:65 年) 包括 40,男性(49.4%) 和有阴暗胃肠的流血的 41 女性(50.6%) 经历了在 1990 和 2004 之间的 IOE。病人从一个数据库被识别,数据回顾地从病人的图表被选择。所有病人在 IOE 前经历了至少一非诊断的 esophagogastroduodenoscopy,结肠镜检查,标准肠寄生物和否定腹的超声扫描。结果:在病人的中部的最小的血红素水平是 59 + 15 g/L 并且 72.8% 病人以前要求了包装红血球的输送。流血来源在 68 被检测(84%) 病人在 IOE 期间。Angiodysplasiae 在 44 个病人(54.3%) 被发现, 9 个病人(11.1%) 被溃疡在小肠影响。在小肠的一个肿瘤在另外一个被检测 6 个病人。治疗在大多数病人由 argon-plasma-coagulation,外科的缝术或有限切除术组成了。结论:Intra 起作用的肠寄生物仍然为怀疑的小肠流血的诊断被使用。最近的开发象无线的囊内视镜检查法和两倍汽球肠寄生物那样,以后可以导致 IOE 的代替。 | Ralf Jakobs Dirk Hartmann Claus Benz Dieter Schilling Uwe Weickert Axel Eickhoff Klaus Schoenleben Juergen F Riemann | 2006 | World Journal of Gastroenterology2006，12，2： | 5 |
| 4 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 5 | Improving dyspnea in chronic obstructive pulmonary disease optimal treatment strategies显示文摘 | Klaus F Rabe | 2006 | Proc Am Thorac Soe2006，3，3： | 1 |
| 6 | Fertilizing effects of n-modified brown coal and its consequences to plant, soil and n- leaching losses 显示文摘 | Joachim K Klaus F Lutz B cker | 2003 | Archives of Agronomy and Soil Science2003，49，1： | 1 |
| 7 | A think-film test for measurement of the oxidation and evaporation of ester-type lubricants显示文摘 | Cvitkovic E Klaus E E Lockwood F | 1978 | ASLE Transactions1978，22，4： | 1 |
| 8 | A PhaseⅠ dose-escalation study of regorafenib (BAY 73-4506),an inhibitor of oncogenic,angiogenic,and stromal kinases,in patients with advanced solid tumors显示文摘 | Klaus M Annette F Simone S | | 0，，09： | 1 |
| 9 | Consolidation of unidirectional CF/PEEK composites from commingled yarn prepreg显示文摘 | Lin Ye Klaus F Joachim K | 1995 | Comp Sci and Tech1995，54，： | 1 |
| 10 | Li- pofuscin- and melanin-related fundus autofluorescence in pa- tients with ABCA 4-associated retinal dystrophies 显示文摘 | Simone K Ulrich K Bernhard HF Britta F Silke W Klaus R | 2009 | Am JOphthcdmol2009，147，8： | 1 |
| 11 | Development and Use of the PSU Microoxidation Test for Disel Engine Oils 显示文摘 | J M Perez F A Kelley E E Klaus | 1987 | SAE SP Paper NO 8720281987，，： | 1 |
| 12 | Moderately elevated plant sterol levels are associated with reduced cardiovascular risk-the LASA study显示文摘 | Klaus F | 2008 | Atherosclerosis2008，196，： | 1 |
| 13 | Correlation ofhistological vessel characteristics and diffusion-weightedimaging intravoxel incoherent motion-derived parameters inpancreatic ductal adenocarcinomas and pancreaticneuroendocrine tumors 显示文摘 | KLAU M MAYER P BERGMANN F | 2015 | Invest Radioi2015，50，11： | 1 |
| 14 | Global Assessment of Gastrointestinal Endoscopic Skills (GAGES): a valid measurement tool for technical skills in flexible endoscopy显示文摘 | Melina C. Vassiliou Pepa A. Kaneva Benjamin K. Poulose Brian J. Dunkin Jeffrey M. Marks Riadh Sadik Gideon Sroka Mehran Anvari Klaus Thaler Gina L. Adrales Jeffrey W. Hazey Jenifer R. Lightdale Vic Velanovich Lee L. Swanstrom John D. Mellinger Gerald M. F | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 15 | Procedurally fair and stable matching显示文摘 | Klaus B Klijn F | 2006 | Economic Theory2006，27，2： | 1 |
| 16 | Multivagent system: which research forwhich applications 显示文摘 | Eugenio O Klaus F | 1999 | Robotics and Autonomous Systems1999，，27： | 1 |
| 17 | Google econometrics and unemployment forecast 显示文摘 | Askitas Nikolaos Zimmermann Klaus F | 2009 | Applied economics Quarterly2009，55，2： | 1 |
| 18 | Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4显示文摘 | Miriam E. Jaax Krystin Krauel Thomas Marschall Sven Brandt Julia Gansler Birgitt Fürll Bettina Appel Silvia Fischer Stephan Block Christiane A. Helm Sabine Müller Klaus T. Preissner Andreas Greinacher | 2013 | Blood2013，，： | 1 |
| 19 | Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary显示文摘 | Klaus F Suzanne H Antonio A | 2007 | Respir Crit Care Med2007，176，5： | 1 |
| 20 | Up-regulation of hypertonicity- activated myo-inositol transporter SMIT1 by the cell volume-sensitive protein kinase SGK1显示文摘 | Klaus F Palmada M Lindner R et al | 2008 | J Physiol2008，586，6： | 1 |
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