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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Lifetime physical activity and breast cancer risk in a multiethnic population:the Francisco Bay area breast cancer study显示文摘 | John EM Horn-ross PL Koo J | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，111： | 2 |
| 3 | Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reduetase from Candida parapsilosis, and its functional expression in Candida tropicalis 显示文摘 | Lee J K Koo B S Kim S Y | 2003 | Appl Environ Microbiol2003，69，10： | 1 |
| 4 | A case of cerebral infarct in combined antiphospholipid antibody and ovarian hyperstimulation syndrome显示文摘 | Koo E J Rha J H Lee B I | 2002 | J Korean Med Sci2002，17，4： | 1 |
| 5 | Cancer of the stomach:a review of two hospitals in Korea and Japan显示文摘 | Mok Y J Koo B W Whang C W | 1993 | World J Surg1993，17，6： | 1 |
| 6 | Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis显示文摘 | Koo KH Lee JS Lee Y J | 2006 | J Orthop Res2006，24，： | 1 |
| 7 | Effect of simulated gastric fluid and bile on survival of Vibrio vulnificus andVibrio vulnificus phage 显示文摘 | Koo J DePaola A Marshall D L | 2000 | J Food Prot2000，63，12： | 1 |
| 8 | Catalyst-free growth of single-crystal silicon and germanium nanowires 显示文摘 | Kim B S Koo T W Lee J H | 2009 | Nano Lett2009，9，2： | 1 |
| 9 | Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos显示文摘 | Kang Y K Park J S Koo D B Choi Y H Kim S U Lee K K Han Y M | 2002 | The EMBO journal2002，21，5： | 1 |
| 10 | Production of lactic acid from paper sludge by simultaneous saccharification and fermentation 显示文摘 | Lee S M Koo Y M Lin J | 2004 | Ad- vances in Biochemical Engineering/Biotechnology2004，87，： | 1 |
| 11 | Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice 显示文摘 | Kang E B Kwon I S Koo J H | 2013 | Apoptosis2013，18，11： | 1 |
| 12 | Tonsillectomy as a treatment for psoriasis: a review显示文摘 | Wu W Debbaneh M Moslehi H Koo J Liao W | 2014 | The Journal of dermatological treat- ment2014，25，6： | 1 |
| 13 | The use of 308nm exeimer laser as an effective and safe treatment for psoriasis in the geriatric population显示文摘 | Wong JW Koo J | 2012 | J Am Geriatr Soc2012，60，4： | 1 |
| 14 | Difference of delayed post tonsil- lectomy bleeding between children and adults 显示文摘 | Kiln D W Koo J W Ahu S H | 2010 | Auris Na- sus Larynx2010，2010，4： | 1 |
| 15 | Development of high-driving potential and high-efficiency Mg-based sacrificial anodes for cathodic protection显示文摘 | KIM J G JOO J H KOO S J | 2000 | Journal of Materials Science Letters2000，19，6： | 1 |
| 16 | Effect of fetal calf serum,amino acids,vitamins and insulin on blastocel formation and hatching of in vivo and IVM/IVF-derived porcine embryos developing in vitro显示文摘 | Koo D B Williams J E Conaghan J | 1997 | Theriogenology1997，48，： | 1 |
| 17 | Aberrant methylation of donor genome in cloned bovine embryos显示文摘 | Kang Y K Koo D B Park J S | 2001 | Nat Ganet2001，28，： | 1 |
| 18 | Application of a new portable microscopic somatic cell counter with disposable plastic chip for milk analysis 显示文摘 | Moon J S Koo H C Joo Y S etal | 2007 | J Dairy Sci2007，90，： | 1 |
| 19 | Synthesis of integral transform solutions for the reconstruction of particle-size distributions from forward-scattered light显示文摘 | KOO J H HIRLEMAN E D | 1992 | Applied Optics1992，31，12： | 1 |
| 20 | Financial Liberalization and Corporate In- vestments: Evidence from Korean Firm Data 显示文摘 | Koo J Shin S | 2004 | Asian Economic Journal2004，，18： | 1 |
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