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| 1 | The role of open lung biopsy in the management and outcome of patients with diffuse lung disease 显示文摘 | Kramer M R Berkman N Mintz B | 1998 | Ann Thorac Surg1998，65，： | 2 |
| 2 | Creativity under the gun 显示文摘 | Amabile T M Hadley C N & Kramer S J | 2002 | Harvard Business Review2002，，80： | 1 |
| 3 | Nanocelluloses as innovative polymers in research and application显示文摘 | Klemm D Schumann D Kramer F He(B)ler N Hornung M Schmauder H P Marsch S | | 0，，09： | 1 |
| 4 | Rapid and simple determination of doxycycline in serum by high-performance liquid chromatography Application to particulate drug delivel7 systems 显示文摘 | Ruz N Zabala M Kramer MG | 2004 | J ChromatogrA2004，1031，12： | 1 |
| 5 | In vitro and in vivo comparative study of chimeric liver-specific promoters显示文摘 | Kramer MG Barajas M Razquin N | 2003 | Mol Ther2003，7，3： | 1 |
| 6 | Influence of Group II&III Base Oil Composition on VI and Oxidation Stability显示文摘 | Kramer D C Ziemer J N Cheng M T | 2000 | NLGI SPOKESMAN2000，63，10： | 1 |
| 7 | Transition metal transport 显示文摘 | KRAMER U TALKE I N HANIKENNE M | 2007 | FEBS Lett2007，581，12： | 1 |
| 8 | ADHD candidate gene(DRD4 exon III) affects inhibitory control in a healthy sample显示文摘 | Kramer U M Rojo N Schule R | 2009 | BMC Neurosci2009，10，： | 1 |
| 9 | Distinct mechanism for antidepressant activity by blockade of central substance P receptors显示文摘 | Kramer M S Cutler N Feighner J | 1998 | Science1998，281，： | 1 |
| 10 | Develop- ment of a partition-controlled dosing system for cell assays 显示文摘 | Kramer N I Busser F J Oosterwijk M T | 2010 | Chemical Research in Toxicology2010，23，11： | 1 |
| 11 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 12 | Development of a Cryptosporidiurn oocyst assay using an automa- ted fiber optic-based biosensor显示文摘 | Kramer M F Vesey G Look N L | 2007 | J Biol Eng2007，，1： | 1 |
| 13 | A novel role of the hedgehog pathway in lens regeneration显示文摘 | Tsonis P A Vergara M N Spence J R Madhavan M Kramer E L Call M K | 2004 | Dev Biol2004，267，： | 1 |
| 14 | In vitro and in vivo conparative study of chimeric liver-specific promoters显示文摘 | Kramer M G Barajas M Razquin N | 2003 | Molec- ular Therapy2003，7，3： | 1 |
| 15 | Influence of Group Ⅱ & Ⅵ Base Oil Composition on VI and Oxidation Sta- bilitv显示文摘 | Kramer D C Ziemer J N Cheng M T | 2000 | NLGISpokesman2000，63，10： | 1 |
| 16 | Regional hetero- geneity of function in hypertmphic cardiomyopathy显示文摘 | Kramer C M Reichek N Feirrari V A | 1994 | Circula- tion1994，90，1： | 1 |
| 17 | Outcomes following liver transplantation in intensive care unit patients显示文摘AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient survival.METHODS:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December 2010.RESULTS:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and norepinephrine.Sixteen ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to transplantation.Twenty-five ICU patients (64%) required dialysis preoperatively.At 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU patients.Patient survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU patients.When formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable analysis.These findings were consistent in multivariable analysis.Although not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (RR:4.19,P=0.033).Graft survival and patient survival were not significantly worse for patients on mechanical ventilation (RR:0.91,P=0.88 in graft loss;RR:0.69,P=0.56 in death) or patients on vasopressors (RR:1.06,P=0.93 in graft loss;RR:1.24,P=0.74 in death) immediately prior to LT.Trends toward lower graft survival and patient survival were observed for patients on dialysis immediately before LT,however these findings did not approach statistical significance (RR:1.70,P=0.43 in graft loss;RR:1.46,P=0.58 in death).CONCLUSION:Although ICU patients when compared to non-ICU patients have lower survivals,outcomes are still acceptable.Pre-transplant ventilation,hemodialysis,and vasopressors were not associated with adverse outcomes. | Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen | 2013 | World Journal of Hepatology2013，5，1： | 1 |
| 18 | Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei,Trypanosoma cruzi and Leishmania major 显示文摘 | Kramer S Kimblin N C Carrington M | 2010 | BMC genomics2010，11，： | 1 |
| 19 | Do preschools differ in promoting children's physical activity?An instrument for the assessment of preschool physical activity programmes显示文摘 | Sterdt E Pape N Kramer S Urban M Werning R Walter U | 2013 | BMC public health2013，13，： | 1 |
| 20 | The preparation, testing and certification of two freshwater sediment reference materials for polycyclic aromatic hydrocarbons and polychlorinated biphenyls: BCR CRM 535 and CRM 536 显示文摘 | Wegener J W M Cofino W P Maier E A Kramer G N | 1999 | Trends in Analytical Chemistry1999，18，1： | 1 |
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