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| 1 | Gut dysbiosis and small intestinal bacterial overgrowth as independent forms of gut microbiota disorders in cirrhosis显示文摘BACKGROUND Gut dysbiosis and small intestinal bacterial overgrowth(SIBO)are commonly observed in patients with cirrhosis.Despite the substantial number of articles describing the relations between disorders of gut microbiota and various manifestations of cirrhosis,dysbiosis and SIBO were always studied separately.AIM To study the relationship of gut dysbiosis and SIBO in cirrhosis.METHODS This observational study included 47 in-patients with cirrhosis.Stool microbiome was assessed using 16 S r RNA gene sequencing.SIBO was assessed using the lactulose hydrogen breath test.RESULTS SIBO was found in 24/47(51.1%)patients.Patients with SIBO had a higher abundance of Firmicutes(P=0.017)and Fusobacteria(P=0.011),and a lower abundance of Bacteroidetes(P=0.013)than patients without SIBO.This increase in the abundance of Firmicutes occurred mainly due to an increase in the abundance of bacteria from the genus Blautia(P=0.020)of the Lachnospiraceae family(P=0.047),while the abundance of other major families of this phylum[Ruminococcaceae(P=0.856),Peptostreptococcaceae(P=0.066),Clostridiaceae(P=0.463),Eubacteriaceae(P=0.463),Lactobacillaceae(P=0.413),and Veillonellaceae(P=0.632)]did not differ significantly between the patients with and without SIBO.Reduced level of Bacteroidetes in samples from patients with SIBO was a result of the decrease in bacterial numbers from all the major families of this phylum[Bacteroidaceae(P=0.014),Porphyromonadaceae(P=0.002),and Rikenellaceae(P=0.047)],with the exception of Prevotellaceae(P=0.941).There were no significant differences in the abundance of taxa that were the main biomarkers of cirrhosis-associated gut dysbiosis[Proteobacteria(P=0.790),Bacilli(P=0.573),Enterobacteriaceae(P=0.632),Streptococcaceae(P=0.170),Staphylococcaceae(P=0.450),and Enterococcaceae(P=0.873)]between patients with and without SIBO.CONCLUSION Despite the differences observed in the gut microbiome between patients with and without SIBO,gut dysbiosis and SIBO are most likely independent disorders of gut microbiota in cirrhosis. | Roman Maslennikov Vladimir Ivashkin Irina Efremova Elena Poluektova Anna Kudryavtseva George Krasnov | 2022 | World Journal of Gastroenterology2022，28，10： | 2 |
| 2 | Preparation and catalytic applications of partially fluorinated binaphthol ligand显示文摘 | Yekta S KrasnovaL B Miampillai B | 2004 | Journal of Fluorine Chemistry2004，125，4： | 1 |
| 3 | Q-switched laser iridectomy and Q-switched laser goniopuncture显示文摘 | Krasnov MM | 1977 | Adv Ophthalmol1977，34，2： | 1 |
| 4 | Resource predictability and host specificity in fleas: the effect of host body mass 显示文摘 | Krasnov B R Morand S Mouillot D | 2006 | Parasitology2006，133，： | 1 |
| 5 | Abundance patterns and coexistence processes in communities of fleas parasitic on small mammals 显示文摘 | Krasnov B R Mouillot D Shenbrot G I | 2005 | Ecography2005，28，： | 1 |
| 6 | Effects of spaceflight on hypothalamic peptide systems controlling pituitary growth hormone dynamics 显示文摘 | Sawchenko P E Arias C Krasnov I | 1992 | J Appl Physiol1992，73，： | 1 |
| 7 | Externalization of Schlemm' s canlal (Sinusotomy) in glaucoma显示文摘 | Krasnov MM | 1968 | Br J Ophthalmol1968，52，2： | 1 |
| 8 | Relationshipsbetween parasite abundance and the taxonomic distance among a parasite'shost species:An example with fleas parasitic on small mammals显示文摘 | KRASNOV B R SHENBROT G I KHOKHLOVA I S | 2010 | Int JParasitol2010，34，： | 1 |
| 9 | Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse(Le pe ophthe irus s almonis)revealed biphasic responses coinciding with the copepod-chalimus transition显示文摘 | Tadiso T M Krasnov A Skugor S | 2011 | BMC Genomics2011，12，： | 1 |
| 10 | The 14-3-3 proteins in the teleost fish rainbow trout(Oncorhynchus mykiss)显示文摘 | Koskinen H Krasnov A Rexroad C | 2004 | Journal of Experimental Biology2004，207，19： | 1 |
| 11 | Search for potential gastric cancer markers using miRNA databases and gene expression analysis显示文摘 | Volkomorov V Grigoryeva E Krasnov G | | 0，，01： | 1 |
| 12 | Clinical and pathogenetic relationships between immuno-inflam- matory rheumatic diseases and psychic disorders 显示文摘 | Lisitsina TA Vel'tishchev DIu Krasnov VN | 2014 | KlinMed (Mosk)2014，92，1： | 1 |
| 13 | A system of beam energy measurement based on the Compton backscattered laser photons for the VEPP-2000 electron–positron collider显示文摘 | E.V. Abakumova M.N. Achasov D.E. Berkaev V.V. Kaminsky I.A. Koop A.A. Korol S.V. Koshuba A.A. Krasnov N.Yu. Muchnoi E.A. Perevedentsev E.E. Pyata P.Yu. Shatunov Yu.M. Shatunov D.B. Shwartz | 2014 | Nuclear Inst. and Methods in Physics Research, A2014，，： | 1 |
| 14 | Ecological characteristics of flea species relate to their suitability as plague vectors显示文摘 | Krasnov BR Shenbrot GI Mouillot D | 2006 | Oecologia2006，149，3： | 1 |
| 15 | Effect of nanometer-size iron particles on surface properties of UHMPE (ultrahighmolecular-weight polyethylene )显示文摘 | Krasnov A P Sergeev V A Makina L B | 1995 | Phys Chem Mech Surface1995，10，10： | 1 |
| 16 | Annual cycles of four species in the central Negev desert 显示文摘 | Krasnov BR Burdelova NV Shenbrot GI | 2002 | Med Veterinary Entomol2002，16，1： | 1 |
| 17 | A simple mechanistic model for void-fraction and pressure-gradient prediction in vertical and inclined gas/liquid flow显示文摘 | Khasanov M Khabibullin R Krasnov V | 2009 | SPE Production & Operations2009，24，1： | 1 |
| 18 | Phenolic compounds of Rhodiola gelida显示文摘 | Krasnov EA Alekseyuk NV | 1979 | Chemistry of Natural Compounds1979，15，6： | 1 |
| 19 | Flavonoids of Rhodiola litvinovii显示文摘 | Krasnov EA | 1979 | Chemistry of Natural Compounds1979，15，6： | 1 |
| 20 | New flavonol glycosides of Rhodiola algida显示文摘 | Krasnov EA Demidenko LA | 1979 | Chemistry of Natural Compounds1979，15，3： | 1 |
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