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| 1 | Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics显示文摘Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules and cells.Among others,methacrylated gelatin(GelMA)has become a representative hydrogel formulation,finding various biomedical applications.Recent efforts on GelMA-based hydrogels have been devoted to combining them with bioactive and functional nanomaterials,aiming to provide enhanced physicochemical and biological properties to GelMA.The benefits of this approach are multiple:i)reinforcing mechanical properties,ii)modulating viscoelastic property to allow 3D printability of bio-inks,iii)rendering electrical/magnetic property to produce electro-/magneto-active hydrogels for the repair of specific tissues(e.g.,muscle,nerve),iv)providing stimuli-responsiveness to actively deliver therapeutic molecules,and v)endowing therapeutic capacity in tissue repair process(e.g.,antioxidant effects).The nanomaterial-combined GelMA systems have shown significantly enhanced and extraordinary behaviors in various tissues(bone,skin,cardiac,and nerve)that are rarely observable with GelMA.Here we systematically review these recent efforts in nanomaterials-combined GelMA hydrogels that are considered as next-generation multifunctional platforms for tissue therapeutics.The approaches used in GelMA can also apply to other existing polymeric hydrogel systems. | Amal George Kurian Rajendra KSingh Kapil DPatel Jung-Hwan Lee Hae-Won Kim | 2022 | Bioactive Materials2022，7，2： | 11 |
| 2 | Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance显示文摘BACKGROUND Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, NILCO] has been associated with breast cancer progression. This complex signaling crosstalk affects cancer cell proliferation, migration, invasion, angiogenesis, apoptosis and chemoresistance. NILCO expression was previously detected in human EmCa. However, it is unknown whether leptin regulates NILCO and alters EmCa’s response to chemotherapeutics. It is hypothesized that leptin induces NILCO and increases aggressiveness and chemoresistance in EmCa cells. AIM To determine whether leptin induces NILCO molecules in EmCa affecting cell proliferation, aggressiveness and chemoresistance. METHODS Leptin’s effects on the expression of NILCO molecules [mRNAs and proteins for Notch receptors (Notch1-4), ligands (JAG1 and DLL4) and downstream effectors (survivin, Hey2), and leptin (OB-R) and IL-1 (IL-1R tI) receptors] was examined in EmCa cells (type I: Ishikawa, and HEC-1A, and type II: An3Ca and KLE) using Real-time PCR and Western blot analysis, respectively. In addition, the effects of leptin on cell cycle, proliferation and cell invasion were determined using cytometric analysis (Cellometer Vision CBA system), MTT cell proliferation and Matrigel-based invasion assays, respectively. Inhibitors of leptin (nanoparticlebound leptin peptide receptor antagonist-2, IONP-LPrA2), IL-1 (anti-IL-1R tI antibody) and Notch (siRNA interference RNA) were used to investigate NILCO’s effects on cell proliferation and invasion. Leptin’s effects on Paclitaxel cytotoxicity in EmCa cells was determined by the CCK8 and Cellometer-based Annexin V assays. RESULTS For the first time it was shown that leptin is an inducer of Notch in EmCa. Experimental data suggest that leptin induced the expression of NILCO molecules, promoted proliferation and S- phase progression, and reduced Paclitaxel cytotoxicity on EmCa cells. Leptin’s effects were higher in type II EmCa cells. The progression of this more aggressive form of the disease is associated with obesity. Remarkably, the use of the leptin signaling antagonist, IONPLPrA2, re-sensitized EmCa cells to Paclitaxel. CONCLUSION Present data suggest the notion that leptin-induced NILCO could be a link between obesity and EmCa progression and chemoresistance. Most aggressive type II EmCa cells were higher sensitive to leptin, which appears to increase proliferation, cell cycle progression, aggressiveness, and chemoresistance to Paclitaxel. Therefore, leptin and NILCO could be novel therapeutic targets for type II EmCa, which does not have targeted therapy. Overall, IONP-LPrA2 has a potential as a novel adjuvant drug to enhance the effectiveness of type II EmCa chemotherapy. | Danielle Daley-Brown Adriana Harbuzariu Ann Anu Kurian Gabriela Oprea-Ilies Ruben Rene Gonzalez-Perez | 2019 | World Journal of Clinical Oncology2019，10，6： | 5 |
| 3 | Inequalities in care in patients with acute myocardial infarction显示文摘Coronary heart disease is the single largest cause of death in developed countries. Guidelines exist for the management of acute myocardial infarction(AMI),yet despite these,significant inequalities exist in the care of these patients. The elderly,deprived socioeconomic groups,females and non-caucasians are the patient populations where practice tends to deviate more frequently from the evidence base. Elderly patients often had higher mortality rates after having an AMI compared to younger patients. They also tended to present with symptoms that were not entirely consistent with an AMI,thus partially contributing to the inequalities in care that is seen between younger and older patients. Furthermore the lack of guidelines in the elderly age group presenting with AMI can often make decision making challenging and may account for the discrepancies in care that are prevalent between younger and older patients. Other patients such as those from a lower socioeconomic group,i.e.,low income and less than high school education often had poorer health and reduced life expectancy compared to patients from a higher socioeconomic group after an AMI. Lower socioeconomic status was also seen to be contributing to racial and geographical variation is the care in AMI patients. Females with an AMI were treated less aggressively and had poorer outcomes when compared to males. However even when females were treated in the same way they continued to have higher in hospital mortality which suggests that gender may well account for differences in outcomes. The purpose of this review is to identify the inequalities in care for patients who present with an AMI and explore potential reasons for why these occur. Greater attention to the management and a better understanding of the root causes of these inequalities in care may help to reduce morbidity and mortality rates associated with AMI. | Shabnam Rashid Alexander Simms Phillip Batin John Kurian Chris P Gale | 2015 | World Journal of Cardiology2015，7，12： | 4 |
| 4 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 5 | Methanol extract of Desmodium gangeticum DC root mimetic post-conditioning effect in isolated perfused rat heart by stimulating muscarinic receptors显示文摘Objective:To evaluate pharmacological mimetic action of herbal extract Desmodium gangeticum (DC) roots on ischemia reperfusion injury.Methods:With the help of Langendroff perfusion technique,ischemic post condition(POC) mimetic action of DG methanol root extract was evaluated and compared by using standard drugs that acts as muscarinic receptor agonist and antagonist,namely acetylcholine(Ach) and atropine(Atr) respectively in an isolated rat heart. Results:The physiological parameters like left ventricular developed pressure,end diastolic pressure and working index of isolated rat heart showed significant recovery in DG root extract administrated rat heart,similar to the recovery by POC.Kymogram results showed muscarinic receptor agonist like action for DG methanol root extract,confirmed in rat heart by muscarnic receptor agonist(acetylcholine) and anatoginst(atropine).Administration of DC root extract prior to reperfusion showed better antioxidant status in myocardial tissue homogenate and mitochondrial,complemented by the levels of cardiac specific marker proteins in myocardial tissue and perfusate.Even though DG methanol root extract mimics its action similar to that of Ach,the myocardial protection mediated by the extract was superior to Ach,due to the presence of antioxidants in the crude extract.Conclusions:DG methanol root extract provides myocardial protection towards IRI by stimulating muscarinic receptors. | Gino A Kurian Jose Paddikkala | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，6： | 3 |
| 6 | Mooring System Optimisation and Effect of Different Line Design Variables on Motions of Truss Spar Platforms in Intact and Damaged Conditions显示文摘This paper presents the effect of mooring diameters, fairlead slopes and pretensions on the dynamic responses of a truss spar platform in intact and damaged line conditions. The platform is modelled as a rigid body with three degrees-of-freedom and its motions are analysed in time-domain using the implicit Newmark Beta technique. The mooring restoring force-excursion relationship is evaluated using quasi-static approach. MATLAB codes DATSpar and QSAML, are developed to compute the dynamic responses of truss spar platform and to determine the mooring system stiffness. To eliminate the conventional trial and error approach in the mooring system design, a numerical tool is also developed and described in this paper for optimising the mooring configuration. It has a graphical user interface and includes regrouping particle swarm optimisation technique combined with DATSpar and QSAML. A case study of truss spar platform with ten mooring lines is analysed using this numerical tool. The results show that optimum mooring system design benefits the oil and gas industry to economise the project cost in terms of material, weight, structural load onto the platform as well as manpower requirements. This tool is useful especially for the preliminary design of truss spar platforms and its mooring system. | O.A. Montasir A. Yenduri V.J. Kurian | 2019 | China Ocean Engineering2019，33，4： | 3 |
| 7 | Acute coronary syndromes: an old age problem显示文摘在老年的增加的人口将导致他们的更大的数字与急性冠的症候群(交流) 介绍。这在全球保健资源上有含意并且为基于证据的治疗要求更好的管理和选择。老比更年轻的交流是有更重要的治疗好处的一个高风险组。不过,在交流的相关不平等在乎的年龄被认出并且坚持。到某程度,在照顾的这差异被不正常、推迟的演讲的更高的频率在表示在老、不太诊断的心电图解释,加强在交流的延期诊断。在死亡风险在的评价下面由于为生理的脆弱,合作病态,认知 / 心理的缺陷和物理残疾的有限考虑老,由心病学专家和 randomised 的缺乏的更少的输入,指导管理在的控制试用数据老可以进一步使照顾的不平等惊讶。当这些不平等存在时,在那里仍然是一个实质的机会改进年龄相关交流结果。为特定的治疗和药政体的老病人的选择是未答复的。对 randomised 有成长需要,人口更代表性并且与合作病态先进年龄注册那些的控制试用数据。不利事件报导的缺乏,张贴冠的 angiography 例如肾的缺陷,在老进一步的限制风险利益决定。在老交流病人的照顾的实质的改进被要求并且应该被倡导。最终,这些改进是可能的导致更好的结果柱子交流。然而,在结果的改进不是无限的并且将由年龄相关的风险的非可修改的因素有限。 | Alexander D Simms Philip D Batin John Kurian Nigel Durham Christopher P Gale | 2012 | Journal of Geriatric Cardiology2012，9，2： | 3 |
| 8 | Ixora Coccinea Linn:Traditional Uses,Phytochemistry and Pharmacology显示文摘Ixora coccinea 悬崖,(Rubiaceae ) 通常作为天竺葵和红 ixora 的丛林知道,一常绿树在整个印度发现的灌木。取决于医药条件,花,叶子,根,和茎被用来在药的印度传统的系统治疗各种各样的疾病, Ayurveda,并且另外在各种各样的民间药。水果充分成熟,被用作饮食的来源。Phytochemical 研究显示植物包含象 lupeol 那样的重要 phytochemicals, ursolic 酸, oleanolic 酸, sitosterol,卢丁, lecocyanadin, anthocyanins, proanthocyanidins, kaempferol 和橡黄素的 glycosides。药理学研究建议植物拥有抗氧化,抗菌剂, gastroprotective, hepatoprotective,止泻剂, antinociceptive, antimutagenic, antineoplastic 和 chemopreventive 完成,因此把科学支持借给植物 ethnomedicinal 使用。在现在的评论,努力在探讨它的 ethnomedicinal 使用,化学成分,和验证药理学观察被作。 | Manjeshwar Shrinath Baliga Poruthukaran John Kurian | 2012 | Chinese Journal of Integrative Medicine2012，18，1： | 3 |
| 9 | Demystifying graph processing frameworks and benchmarks显示文摘Dear editor,Graph algorithms have become important because of the increasing need to extract information from big data[1].Due to huge volumes of data and irregular communication patterns[2],it is a challenging task to apply graph algorithms efficiently. | Junyong DENG Qinzhe WU Xiaoyan WU Shuang SONG Joseph DEAN Lizy Kurian JOHN | 2020 | Science China(Information Sciences)2020，63，12： | 3 |
| 10 | A Comparative Study on Comprehensive, Objective Outcomes of Laparoscopic Heller Myotomy With Per-Oral Endoscopic Myotomy (POEM) for Achalasia显示文摘 | Neil H. Bhayani Ashwin A. Kurian Christy M. Dunst Ahmed M. Sharata Erwin Rieder Lee L. Swanstrom | 2014 | Annals of Surgery2014，，6： | 2 |
| 11 | Investigation on the Dynamic Responses of a Truss Spar Platform for Different Mooring Line Groups显示文摘任何漂浮的平台的动态回答依赖于团,僵硬和身体以及系在的系统的抑制特征。因此,学习对能最后帮助他们的费用到节俭的系统的单个贡献的效果是很必要的。这份报纸在一个 truss 圆材平台的回答上集中于系在的僵硬的效果,由线的不同组织获得了。学习是我们关于包括线虚荣,直径和方位角角度的效果的系在的系统的现在的研究的部分。站台与三 degrees-of-freedom 作为僵硬身体被建模,它的运动用含蓄的 Newmark 贝它技术在时间域被分析。系在的线恢复力量旅行关系用一条伪静电干扰途径被评估。有线的系在的系统以恢复力量以及平台的吝啬的位置在组展览的更少的数字安排了更好的性能,这被观察。然而,站台的动态运动为不同的线组仍然保持未受影响。 | Montasir Osman Ahmed Anurag Yenduri V. J. Kurian | 2015 | Journal of Marine Science and Application2015，14，2： | 2 |
| 12 | Long-Term Outcomes of an Endoscopic Myotomy for Achalasia: The POEM Procedure显示文摘 | Lee L. Swanstrom Ashwin Kurian Christy M. Dunst Ahmed Sharata Neil Bhayani Erwin Rieder | 2012 | Annals of Surgery2012，，4： | 2 |
| 13 | A cost-effectiveness analysis of adju- vant trastuzumab regimens in early HER2/neu-positive breast cancer 显示文摘 | Kurian AW Thompson RN Gaw AF | 2007 | J Clin Onco12007，25，： | 1 |
| 14 | Childhood disorders of neurodegeneration with brain iron accumulation (NBIA) 显示文摘 | Kurian MA McNeill A Lin JP | 2011 | Dev Med Child Neurol2011，53，： | 1 |
| 15 | Current effective topical therapies in the management of psoriasis显示文摘 | Kurian A Barankin B | 2011 | Skin Therapy Lett2011，16，1： | 1 |
| 16 | The use of electrical stimulation of the vagus nerve to treat morbid obesity显示文摘 | Roslin M Kurian M | 2001 | Epilepsy Behav2001，，2： | 1 |
| 17 | Anti-nmda receptor encephalitis: The importance of early diagnosis and aggressive immunothera- py in tumor negative pediatric patients显示文摘 | Kurian M Fluss J Korff C | 2012 | Eur J Paediatr Neu- rol2012，16，： | 1 |
| 18 | Pantothenate kinase-associated neurodegeneration ( PKAN ) and PLA2G6-associated neurodegeneration ( PLAN ): review of two major neurodegeneration with brain iron accumulation ( NBIA ) phenotypes 显示文摘 | Kurian MA Hayflick SJ | 2013 | Int Rev Neurobiol2013，110，： | 1 |
| 19 | The metabolic and immune response to laparoscopic versus open liver resection显示文摘 | Burpee SE Kurian M Marakame Y | 2002 | Surg Endosc2002，16，6： | 1 |
| 20 | The sealed lead-acid battery:performance and present aircraft applications显示文摘 | John Timmons Raju Kurian | 2004 | ELSEVIER Journal of Power Sources2004，136，： | 1 |
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