|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 国际疼痛研究协会疼痛定义修订版:概念、挑战和折中显示文摘现行国际疼痛研究协会(IASP)将疼痛定义为'与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验',该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为'与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验',并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。 | Raja SN.Carr DB Cohen M.Finnerup NB Flor H.Gibson S Keefe FJ.Mogil JS Ringkamp M.Sluka KA Song XJ.Stevens B Sullivan MD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) | 2020 | 中华疼痛学杂志2020，16，5： | 137 |
| 2 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 3 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 4 | Tuberous sclerosis complex: renal imaging findings 显示文摘 | Casper KA Donnelly LF Chen B | 2002 | Radiology2002，225，： | 2 |
| 5 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 6 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 7 | 年龄≥65岁男性收缩压与血管疾病的相关性显示文摘老年人血压与血管疾病的关系尚不确定。1996-1999年,在澳大利亚西部帕斯普通人群中建立65~94岁男性7564人的前瞻性队列,评估收缩压与主要血管事件的相关性。测定基线和2001-2004年再调查时的收缩压。记录受试者的致命性及非致命性血管事件。 | Lacey B Golledge J Yeap BB Lewington S McCaul KA Norman PE Flicker L Almeida OP Hankey GJ 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 8 | Treatment with a short course of LF 15-0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat-to-mouse cardiac transplantation model 显示文摘 | Wang H Hosiawa KA Garcia B | 2003 | Xenotransplantation2003，10，4： | 1 |
| 9 | Caspase 3 activation is essential for neuroprotection in preconditioning 显示文摘 | McLaughlin B Hartneu KA Erhardt JA | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 10 | Evaluation of the antioxidant activity of melatonin in vitro显示文摘 | Marshall KA Reiter RJ Poeggeler B | 1996 | Free Radical Biology & Medicine1996，21，3： | 1 |
| 11 | Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation显示文摘 | Qiu B Frait KA Reich F | 2001 | Am J Pathol2001，158，4： | 1 |
| 12 | Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice显示文摘 | McClellan KA Robertson FG Kindblom J Wennbo H Tornell J Bouchard B | 2001 | Invest Ophthalmol Vis Sci2001，42，1： | 1 |
| 13 | Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial 显示文摘 | Freeman EW Guthrie KA Caan B | 2011 | JAMA2011，305，3： | 1 |
| 14 | Stented versus non- stented pancreaticojejunostomy after pancreatoduodeneetomy: a prospective study显示文摘 | Roder JD Stein HJ B? ttcher KA | 1999 | Ann Surg1999，229，1： | 1 |
| 15 | Flow regulation of collecting duct endothelin-1 production显示文摘 | Lyon-Roberts B Strait KA van Peursem E | 2011 | Am J Physiol Renal Physiol2011，300，3： | 1 |
| 16 | Electroconvulsive therapy for major depression in an elderly person with epilepsy显示文摘 | Kucia KA Stepańczak R Tredzbor B | 2009 | World J Biol Psychiatry2009，10，1： | 1 |
| 17 | GRACE Investigators Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention:the Global Registry of Acute Coronary Events显示文摘 | Nallamothu B Fox KA Kennelly BM | 2007 | Heart2007，93，12： | 1 |
| 18 | Infection control resources in New York State hospitals,2007显示文摘 | Strieof RL Schabses KA Tserenpuntsag B | 2008 | Am J Infect Control2008，36，10： | 1 |
| 19 | Generation of CD4+and CD8+ T lymphocyte responses by dendritic cells armed with PSA/Anti-PSA complexes显示文摘 | Berlyn KA Schultes B Leveugle B | 2001 | Clin Immunol2001，101，3： | 1 |
| 20 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium显示文摘 | MURRY C E JENNING R B REIMER KA | 1986 | Circulation1986，74，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员