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| 1 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 2 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 3 | Single balloon enteroscopy for endoscopic retrograde cholangiography in patients with Roux-en-Y hepaticojejuno anastomosis显示文摘AIM:To evaluate single balloon enteroscopy in diagnostic and therapeutic endoscopic retrograde cholangiography(ERC)in patients with Roux-en-Y hepaticojejunoanastomosis(HJA).METHODS:The study took place from January 2009to December 2011 and we retrospectively assessed 15patients with Roux-en-Y HJA who had signs of biliary obstruction.In total,23 ERC procedures were performed in these patients and a single balloon videoen-teroscope(Olympus SIF Q 180)was used in all of the cases.A transparent overtube was drawn over the videoenteroscope and it freely moved on the working part of the enteroscope.Its distal end was equipped with a silicone balloon that was inflated by air from an external pump at a pressure of≤5.4 kPa.The technical limitations or rather the parameters of the single balloon enteroscope(working length-200 cm,diameter of the working channel-2.8 mm,absence of Albarran bridge)showed the need for special endoscopic instrumentation.RESULTS:Cannulation success was reached in diagnostic ERC in 12 of 15 patients.ERC findings were normal in 1 of 12 patients.ERC in the remaining 11 patients showed some pathological changes.One of these(cystic bile duct dilation)was subsequently resolved surgically.Endoscopic treatment was initialized in the remaining 10 patients(5 with HJA stenosis,2 with choledocholithiasis,and 3 with both).This treatment was successful in 9 of 10 patients.The endoscopic therapeutic procedures included:balloon dilatation of HJA stenosis-11 times(7 patients);choledocholitiasis extraction-five times(5 patients);biliary plastic stent placement-six times(4 patients);and removal of biliary stents placed by us-six times(4 patients).The mean time of performing a single ERC was 72 min.The longest procedure took 110 min and the shortest took34 min.This shows that it is necessary to allow for more time in individual procedures.Furthermore,these procedures require the presence of an anesthesiologist.We did not observe any complications in these 15 patients.CONCLUSION:This method is more demanding than standard endoscopic retrograde cholangiopancreatography due to altered postsurgical anatomy.However,it is effective,safe,and widens the possibilities of resolving biliary pathology. | Bohuslav Kianika Jan Lata Ivo Novotny Petr Dítě Jirí Vaníek | 2013 | World Journal of Gastroenterology2013，19，44： | 2 |
| 4 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 5 | 载脂蛋白E基因型影响老年人心输出量与认知功能的相关性显示文摘心输出量的轻微下降与低脑血流量相关,尤其是在阿尔茨海默病病理改变的首发区域。载脂蛋白E(apolipoprotein E,APOE)-ε4是阿尔茨海默病的一个遗传易感性危险因素,同时能减轻血管损伤。该研究旨在探讨携带APOE-ε4基因是否影响心输出量与认知功能的相关性。研究人员纳入范德比尔特记忆老化项目中无临床脑卒中和痴呆的参与者306例,平均年龄(73±7)岁,其中42%为女性。 | 陈嘉睿 刘莉 Bown CW Liu D Osborn KE Gupta DK Mendes LA Pechman KR Hohman TJ Wang TJ Gifford KA Jefferson AL | 2019 | 中华高血压杂志2019，27，10： | 2 |
| 6 | Eosinophils in urine revisited显示文摘 | Rutling KA Hoppes P Blend D | 1994 | Clin Nephrol1994，41，1： | 2 |
| 7 | Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors显示文摘 | Walker C Haylock B Husband D Joyce KA Fildes D Jenkirtson MD Smith T Broome J du Plessis DG Warnke PC | 2006 | 中国神经肿瘤杂志2006，4，3： | 2 |
| 8 | Reduction of ethyl benzoylacetate and selective protection of 2- (3-hydroxy-1- phenylpropyl) -4-methylphenol: A new and facile synthesis of tolterodine 显示文摘 | De Castro KA Ko J Park D | 2007 | Org Process Res Dev2007，11，5： | 1 |
| 9 | The 22-mm vs the 32-mm femoral head in cemented primary hip arthroplasty:long-term clinical and radiological follow-up study显示文摘 | Shaju KA Hasan ST D'Souza LG | 2005 | J Arthroplasty2005，20，7： | 1 |
| 10 | Factors predictive of corneal graft survival:report fromo the Australian corneal graft registry显示文摘 | WILLIAMS KA RODER D ESTERMAN A | 1992 | Ophthalmology1992，99，： | 1 |
| 11 | Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population显示文摘 | Bozaoglu K Segal D Shields KA | 2009 | J Clin Endocrinol Metab2009，94，8： | 1 |
| 12 | Corneal asphericity and retinal image quality:a case study and simulations显示文摘 | Somani S Tuan KA Chernyak D | 2004 | J Refract Surg2004，20，5： | 1 |
| 13 | Update on coxsack- ievirus B3 myocarditis 显示文摘 | Fairweather D Stafford KA Sung YK | 2012 | Curr Opin Rheumatol2012，24，： | 1 |
| 14 | Clinical and histopathological features of patients with systemic sclerosis un- dergoing endomyocardial biopsy 显示文摘 | MUELLER KA MUELLER II EPPLER D | 2015 | PLoS One2015，10，01： | 1 |
| 15 | Short-term car- diovascular measures for driver support: Increasing sensitivity for detecting chartges in mental workload 显示文摘 | Stuiver A Brookhuis KA de Waard D | 2014 | International Journal of Psychophysiology2014，92，1： | 1 |
| 16 | Biosensor chip mass spectrometry:a chip-based proteomics approach显示文摘 | Nelsson RW Nedelkov D Tubbs KA | 2000 | Electrophoresis2000，21，6： | 1 |
| 17 | Do adiponectin,TNF alpha,leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes,during and after pregnancy显示文摘 | McLachlan KA O'Neal D Jenkins A | 2006 | Diabetes Metab Res Rev2006，22，2： | 1 |
| 18 | Isoniazid prophylaxis in hepatitis B carriers显示文摘 | McGlynn KA Lustbader E D Sharrar R G | 1986 | Am Rev Respir Dis1986，134，： | 1 |
| 19 | Multicenter, pro- spective, randomized safety and efficacy study of new atrial-based managed ventricular pacing mode (MVP) in dual-chamber ICDs显示文摘 | Sweeney MO Ellenbogen KA Casavant D | 2005 | J Cardiovasc Electrophysiol2005，16，： | 1 |
| 20 | Prevalence, clinical manifestations, etology? and treatment of depression in Parkinson's disease显示文摘 | Slaughter JR?Siaughter KA Nichols D | 2001 | J Neuropsychiatry Clin-Neurosci2001，13，2： | 1 |
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