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| 1 | Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair显示文摘Schwann cell proliferation in peripheral nerve injury(PNI)enhances axonal regeneration compared to central nerve injury.However,even in PNI,long-term nerve damage without repair induces degeneration of neuromuscular junctions(NMJs),and muscle atrophy results in irreversible dysfunction.The peripheral regeneration of motor axons depends on the duration of skeletal muscle denervation.To overcome this difficulty in nerve regeneration,detailed mechanisms should be determined for not only Schwann cells but also NMJ degeneration after PNI and regeneration after nerve repair.Here,we examined motor axon denervation in the tibialis anterior muscle after peroneal nerve transection in thy1-YFP mice and regeneration with nerve reconstruction using allografts.The number of NMJs in the tibialis anterior muscle was maintained up to 4 weeks and then decreased at 6 weeks after injury.In contrast,the number of Schwann cells showed a stepwise decline and then reached a plateau at 6 weeks after injury.For regeneration,we reconstructed the degenerated nerve with an allograft at 4 and 6 weeks after injury,and evaluated functional and histological outcomes for 10 to 12 weeks after grafting.A higher number of pretzel-shaped NMJs in the tibialis anterior muscle and better functional recovery were observed in mice with a 4-week delay in surgery than in those with a 6-week delay.Nerve repair within 4 weeks after PNI is necessary for successful recovery in mice.Prevention of synaptic acetylcholine receptor degeneration may play a key role in peripheral nerve regeneration.All animal experiments were approved by the Institutional Animal Care and Use Committee of Tokyo Medical and Dental University on 5 July 2017,30 March 2018,and 15 May 2019(A2017-311C,A2018-297A,and A2019-248A),respectively. | Leyang Li Hiroyuki Yokoyama Hidetoshi Kaburagi Takashi Hirai Kunikazu Tsuji Mitsuhiro Enomoto Yoshiaki Wakabayashi Atsushi Okawa | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 2 | Phosphorylation of GATA4 Is Involved in α1-Adrenergic Agonist-responsive Transcription of the Endothelin-1 Gene in Cardiac Myocytes显示文摘 | Morimoto T Hasegawa K Kaburagi S | 2000 | J Biol Chem2000，275，13： | 1 |
| 3 | Geometic remodeling and intimal regrowth sa mechanisms of restenosis :Observations from Serial Ultrasund Analysis of Restenosis (SURE) trial 显示文摘 | Kimura T Kaburagi S Tashima Y el | 1995 | Circulation1995，76，： | 1 |
| 4 | Full width at half maximum intensity of the G band in the first order Raman spectrum of carbon material as a parameter for graphitization 显示文摘 | Yoshida A Kaburagi Y Hishiyama Y | 2006 | Carbon2006，44，： | 1 |
| 5 | Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression显示文摘 | Nagaoka T Kaburagi Y Hamaguchi Y | | 0，，： | 1 |
| 6 | Small angle X-ray scattering from voids within fibers during the stabilization and carbonization stages显示文摘 | Miyoshi Kaburagi Yuezhen Bin Dan Zhu | 2003 | Carbon2003，41，： | 1 |
| 7 | Small angle X-ray scattering from voids within fibers during the stabilization and car bonization stages显示文摘 | KABURAGI M BIN Y ZHU D | 2003 | Carbon2003，41，5： | 1 |
| 8 | Small angle X - ray scattering from voids within fibers during the stabilization and carbonization stages 显示文摘 | M Kaburagi Y Bin D Zhu | 2003 | Carbon2003，41，5： | 1 |
| 9 | CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis显示文摘 | Nakatani T Kaburagi Y Shimada Y | 2001 | J Allergy Clin Immunol2001，107，2： | 1 |
| 10 | Acceleration of graphitization in carbon fibers throngh exfoliation显示文摘 | M TOYODA Y KABURAGI A YOSHIDA M INAGKI | 2004 | Carbon2004，42，： | 1 |
| 11 | Phosphorylation of GATA-4 is involved in I -adrenergic agonist- responsive transcription of the endothelin- I gene in cardiac myocytes显示文摘 | MORIMOTO T HASEGAWA K KABURAGI S | 2000 | J Biol Chem2000，275，13： | 1 |
| 12 | Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1显示文摘 | Kaburagi Y Satoh S Yamamoto-Honda R et a1 | 2001 | Diabetologia2001，44，8： | 1 |
| 13 | A new lipophilie pro - vitamin C, tetra - isopalmitoyl aseorbic acid ( VC - IP), prevents UV - induced skin pigmentation through its anti - oxidative properties 显示文摘 | OCHIAI Y KABURAGI S OBAYASHI K | 2006 | Journal of Dermatological Science2006，44，1： | 1 |
| 14 | Potential role of protein kinase B in insuin-induced glucose transport,glycogen synthesis,and protein synthesis显示文摘 | UEKI K YAMAMOTO-HONDA R KABURAGI Y | 1998 | J Biol Chem1998，273，： | 1 |
| 15 | Potential role of protein kinase B in insulin-induced glucose transport,glycogen synthesis and protein synthesis显示文摘 | Yamamoto HR Kaburagi Y | 1998 | J Biol Chem1998，273，： | 1 |
| 16 | Signal transduction pathways from insulin receptors to Ras-analysis of by mutant insulin receptors显示文摘 | Yonezawa k Ando A Kaburagi Y | 1994 | J Biol Chem1994，269，6： | 1 |
| 17 | Impact of functional ABCG2 polymorphisms on the adverse effects of gefitinib in Japanese patients with non-small-cell lung cancer显示文摘 | Akasaka K Kaburagi T Yasuda S | 2010 | Cancer Chemother Pharmacol2010，66，4： | 1 |
| 18 | Enhanced production of CC-chemokines (RANTES, MCP-1, MIP- lalpha, MIP-lbeta, and eotaxin) in patients with atopic dermatitis显示文摘 | Kaburagi Y Shimada Y Nagaoka T | 2001 | Arch Dermatol Res2001，293，7： | 1 |
| 19 | Small angle X-ray scattering from voids within fibers during the stabilization and carbonization stages 显示文摘 | Kaburagi M Bin Y | 2003 | Carbon2003，41，5： | 1 |
| 20 | Insulin- indepen- dent and wortmannin - resistant targeting of Its - 3 to the plasma mem- brane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS - 1显示文摘 | Kaburagi Y Satoh S Yamamoto- Honda R | 2001 | Diabetologia2001，44，： | 1 |
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