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| 1 | 乳腺癌组织中TP和TS及DPD mRNA表达与预后的关系显示文摘目的 探讨乳腺癌组织中胸苷酸化酶 (TP)、胸苷酸合成酶 (TS)和二氢嘧啶脱氢酶(DPD)mRNA表达水平及其与预后的关系。方法 采用real time定量PCR技术检测经过微选的 9例正常乳腺组织和 86例乳腺癌组织TP、TS和DPD的mRNA表达水平。结果 肿瘤组织中TP、TS和DPDmRNA表达水平中位数分别为 16 .5 4 ,0 .38和 2 .74 ,正常乳腺组织分别为 11.75 ,0 .2 5和 8.33,差异均无显著性 (P >0 .0 5 )。除年龄与DPD表达呈负相关外 ,TP、TS和DPDmRNA表达与肿瘤体积、淋巴结转移、组织学分级、临床分期均无相关性。TP、DPD高表达组和低表达组之间 ,无瘤生存期和总生存期差异均无显著性。TS高表达组和低表达组无瘤生存期差异无显著性 (P =0 .0 6 9) ;平均总生存期分别为 5 9.0 0和 70 .30个月 ,差异有显著性 (P =0 .0 4 96 )。结论 仅检测TSmRNA对判断乳腺癌预后有参考价值 ,同时检测TP、TS和DPD具有更好的预测价值。 | 李惠翔 Suo ZH 张云汉 Bjrn Risberg Mats G Karlsson Jahn M Nesland | 2004 | 中华肿瘤杂志2004，26，11： | 9 |
| 2 | Purification and characterisation of acidocin D20079, a bacteriotin produced by LactobaciUus acidophilus DSM 20079 显示文摘 | Deraz S F Karlsson E N Hedstrom M | 2005 | J Biotechnol2005，117，4： | 1 |
| 3 | Molecular epidemiology of methicillin resistant coagulase-negative staphylococci in a Swedish county hospital:evidence of intra and interhospital clonal spread显示文摘 | Widerstrom M Monsen T Karlsson C | 2006 | J Hosp Infect2006，64，： | 1 |
| 4 | Soliton stability in optical fibers with polarization-mode dispersion显示文摘 | Karlsson M Andrekson P | 1998 | IEEE Photon Technol Lett1998，10，3： | 1 |
| 5 | Quantum Entanglement for Secret Sharing and Secret Splitting显示文摘 | Koashi M Imoto N | 1999 | Phys Rev A1999，59，： | 1 |
| 6 | Transvaginal ultrasonography of the endometrium in women with postmenopausal bleeding: a Nordic muhicenter study 显示文摘 | Karlsson B Granverg S Wikland M | 1995 | Am J Obstet Gynecol1995，172，： | 1 |
| 7 | Increased survival of embryonic nigral neurons when grafted to hypothermic rats显示文摘 | Karlsson J Emgar M Gido G | 2000 | Neuroreport2000，11，8： | 1 |
| 8 | Trans-resveratrol protects embryonic mesencephalic cells from tertbutyl hydroperoxide显示文摘 | Karlsson J Emgard M Brundin P | 2000 | Neurochemistry2000，75，： | 1 |
| 9 | Insulin induces translocation of glucose transporter GLUT4 to plasma membrane caveolae in adipocytes显示文摘 | KARLSSON M THORN H PARPAL S | 2002 | FASEB J2002，16，： | 1 |
| 10 | A new minor groove binding asymmetric cyanine reporter dye for real-time PCR显示文摘 | Bengtsson M Karlsson H J Westman G | 2003 | Nucleic Acids Res2003，31，8： | 1 |
| 11 | Wide-area protection and emergency control显示文摘 | Begovic M Novosel D Karlsson D | 2005 | Proceedings of the IEEE2005，93，5： | 1 |
| 12 | Metabolic conditions in porcine longissimus muscle immediately pre- slaughter and its influence on peri- and post mortem ener- gy metabolism显示文摘 | Henckel P Karlsson A Jensen M T | 2002 | Meat Sci2002，62，： | 1 |
| 13 | Transforming growth factobeta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition ( EMT ) through a MEN-dependent mechanism in primary cultured pig thyrocytes显示文摘 | Grfinde M Franzen A Karlsson JO | 2002 | J Cell Sci2002，115，22： | 1 |
| 14 | Tuning the HOMO and LUMO energy levels of organic chromophores for dye sensitized solar ceils 显示文摘 | Hagberg D P Marinado T Karlsson K M | 2007 | J Org Chem2007，72，25： | 1 |
| 15 | Determining plastic properties of a material with residual stress by using conical indentation显示文摘 | YAN J KARLSSON A M CHEN X | 2007 | International Journal of Solids and Structures2007，44，： | 1 |
| 16 | Composites of micro-and mesoporous materials:simultaneous syntheses of MFI/MCM-41 like phases by a mixed template approach显示文摘 | Karlsson A Stocker M Schmidt R | | 0，，2： | 1 |
| 17 | Major obstetric haemorrhage : monitoring with thromboelastography, labora- tory analyses or both? 显示文摘 | Karlsson O Jeppsson A Hellgren M | 2014 | Int J Obstet Anesth2014，23，1： | 1 |
| 18 | Predictive value of procaleitonin decrease in patients with severe sepsis: a prospective observational study显示文摘 | Karlsson S Heikkinen M Pettil V | 2010 | Crit Care2010，14，6： | 1 |
| 19 | Composites of micro--and mesoporous materials: simultaneous syntheses of MFI/ MCM-41 like phases by a mixed temp late approach显示文摘 | Karlsson A Stocker M Schmidt R | 1999 | Mieroporous mesoporous mater1999，27，： | 1 |
| 20 | Introduction for ozone deposition special issue 显示文摘 | Ashmorc M R Emberson L Karlsson P E ct al | 2004 | Atmospheric Environment2004，38，： | 1 |
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