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| 1 | Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells显示文摘 | Liu, Xinjian Li, Fang Huang, Qian Zhang, Zhengxiang Zhou, Ling Deng, Yu Zhou, Min Fleenor, Donald E. Wang, He Kastan, Michael B. Li, Chuan-Yuan | 2017 | Cell Research2017，27，6： | 3 |
| 2 | Posterior ankle impingement–an underdiagnosed cause of ankle pain in pediatric patients显示文摘BACKGROUND Posterior ankle impingement syndrome(PAIS)is a cause of ankle pain due to pinching of bony or soft tissue structures in the hindfoot.The diagnosis is primarily made based on detailed history and accurate clinical examination.The delay in its diagnosis has not yet been described in the pediatric and adolescent population.AIM To identify and characterize misdiagnosed cases of PAIS in pediatric and adolescent patients.METHODS This descriptive prospective study at a tertiary children’s hospital included patients≤18 years who underwent posterior ankle arthroscopy after presenting with chronic posterior ankle pain after being diagnosed with PAIS.Collected data included:Demographics,prior diagnoses and treatments,providers seen,time to diagnosis from presentation,and prior imaging obtained.Visual Analogue Scale(VAS)for pain and American Orthopedic Foot Ankle Society(AOFAS)ankle-hindfoot scores were noted at initial presentation and follow-up.RESULTS 35 patients(46 ankles)with average age of 13 years had an average 19 mo(range 0-60 mo)delay in diagnosis from initial presentation.25(71%)patients had previously seen multiple medical providers and were given multiple other diagnoses.All 46(100%)ankles had tenderness to palpation over the posterior ankle joint.Radiographs were reported normal in 31/42(72%)exams.In 32 ankles who underwent MRI,the most common findings included os trigonum(47%)/Stieda process(47%).Conservative treatment had already been attempted in all patients.Ankle impingement pathology was confirmed during arthroscopy in 46(100%)ankles.At an average follow-up of 13.1 mo,there was an improvement of VAS(pre-op 7.0 to post-op 1.2)and AOFAS scores(pre-op 65.1 to post-op 94).CONCLUSION This is the first study which shows that PAIS is a clinically misdiagnosed cause of posterior ankle pain in pediatric and adolescent population;an increased awareness about this diagnosis is needed amongst providers treating young patients. | Indranil Kushare Kristen Kastan Sachin Allahabadi | 2019 | World Journal of Orthopedics2019，10，10： | 2 |
| 3 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation 显示文摘 | Bakkenist CJ Kastan MB | 2003 | Nature2003，421，6922： | 1 |
| 4 | Cell cycle control and cancer显示文摘 | Hartwell LH Kastan MB | 1994 | zScience1994，266，5192： | 1 |
| 5 | Cell cycle control and cancer显示文摘 | Kastan MB | 1994 | Science1994，266，： | 1 |
| 6 | Cell - cycle checkpoints and cancer 显示文摘 | Kastan MB Bartek J | 2004 | Nature2004，432，7015： | 1 |
| 7 | A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia显示文摘 | Kastan MB Zhan Q El-Deiry WS | 1992 | Cell1992，71，4： | 1 |
| 8 | Cell cycle control and cancer显示文摘 | Hartwell LH Kastan MB | 1994 | Science1994，266，5192： | 1 |
| 9 | Cell cycle control and cancer 显示文摘 | Hartwell LH Kastan MB | 1994 | Science1994，266，： | 1 |
| 10 | Cell-cycle checkpoints and cancer 显示文摘 | KASTAN M B BARTEK J | 2004 | Nature2004，432，7015： | 1 |
| 11 | Participation of ATM in insulin signalling through phosphorylation of 4E-BP1-binding protein 1 显示文摘 | Yang DQ Kastan MB | 2000 | Nat Cell Biol2000，2，12： | 1 |
| 12 | Cell cycle control and cancer显示文摘 | Hartwell L Kastan MB | 1994 | Science1994，226，： | 1 |
| 13 | Cell-cycle checkpoints and cancer显示文摘 | KASTAN MB BARTEK J | 2004 | Nature2004，432，7015： | 1 |
| 14 | Cell-cycle checkpoints and cancer显示文摘 | Kastan M B Bartek J | 2004 | Nature2004，432，7015： | 1 |
| 15 | Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage 显示文摘 | Kessis TD Slebos RL Nelson WG Kastan MB Plunkett BS Han SM Lorincz AT Hedrick L Cho KR | 1993 | Proc Natl Acad Sci USA1993，90，9： | 1 |
| 16 | Participation of p53 protein in the cellular response to DNA damage显示文摘 | Kastan MB Onyekwere O Sidransky D Vogelstein B Craig RW | 1991 | Cancer Res1991，51，231： | 1 |
| 17 | Cell cycle control and cancer显示文摘 | Kastan M B | 1994 | Science1994，266，： | 1 |
| 18 | DNA damage activates ATM through inter- molecular autophosphorylation and dimer dissociation显示文摘 | Kastan MB | 2003 | Nature2003，421，6922： | 1 |
| 19 | Cell cycle control and cancer 显示文摘 | Kastan MB | 1994 | Science1994，266，5192： | 1 |
| 20 | Cell cycle control and cancer显示文摘 | HortweU LH Kastan MB | 1994 | Science1994，266，5192： | 1 |
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