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		题名	作者	年代	出处	被引量
	1	First Scale - Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15 - Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient 显示文摘	Thomas N Michael B Kai D	2005	Org Process Res Dev2005，9，：	1
	2	Fatty infiltration of liver in hyperllpldernicpatients 显示文摘	Asay N Kai ta K Mymln D	2000	Dig Dis Sci2000，45，：	1
	3	Intrauterine growth restriction following ligation of the uterine arter- ies Leads to more severe glomerulosclerosis after Me-sangioproliferative glomerulonephritis in the off spring 显示文摘	Christian P Kai D N Carlos M C	2010	American Journal of Nephrology2010，32，4：	1
	4	Anficancer activity of morpltine andits synthetic derivative, KT-90, mediated through apopoto-sis and inhibition of NF-kB activation显示文摘	Sueoka E Sueoka N Kai Y Okabe S Suganuma M Kanematsu K et d	1998	Biochem Biophys Res Commum1998，252，3：	1
	5	Carbon dioxide speciation in silicate melts:a restart显示文摘	Marcus N Dirk P Kai S Otto D	2003	Earth and Planetary Science Letters2003，207，：	1
	6	Fractional quantum Hall effect in the absence of Landau levels 显示文摘	Sheng D N Gu Zhengcheng Sun Kai	2011	Nature Commun2011，2，：	1
	7	Discovery of gargantulides B and C,new 52-membered macrolactones from Amycolatopsis sp.Complete absolute stereochemistry of the gargantulide family显示文摘Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis sp.strain CA-230715 during an antibacterial screening campaign.The structures of these giant macrolides were elucidated by 2D NMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their backbones.Genome sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKS clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides A-C.The absolute configurations of gargantulides B and C were assigned based on a combination of NMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ PKS.In addition,the absolute stereochemistry of gargantulide A has now been revised and completed.Gargantulides B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii.	Daniel Carretero-Molina Francisco Javier Ortiz-López Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue Sparholt Jorgensen Mercedes de la Cruz Caridad Díaz Francisca Vicente Kai Blin Fernando Reyes Tilmann Weber Olga Genilloud	2022	Organic Chemistry Frontiers2022，9，2：	0

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