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| 1 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 2 | Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct 显示文摘 | Necula M Kayed R Milton S | 2007 | J Biol Chem2007，282，10： | 1 |
| 3 | Source and tectonic implications of tonalite-trondhjemite magmatism in the Klarnath Mountains 显示文摘 | Barnes C G Petersen S W Kistler R W Murray R Kays M A | 1996 | Contrib Mineral Petrol1996，123，1： | 1 |
| 4 | Rapid uptake of 15N-ammonium and glycine- 13C, 15N by arbuscular and ericoid mycorrhizal plants native to a Northern California coastal pygmy forest显示文摘 | Kai C R Caroline S 13 | 2007 | Soil Biology and Biochemistry2007，39，10： | 1 |
| 5 | Inhibition of photosynthesis by ethylene-a stomatal effect显示文摘 | James E Pallas J R Kays S J | 1982 | Plant Physiology1982，70，2： | 1 |
| 6 | Autoregulation of microRNA biogenesis by let-7 and Argonaute显示文摘 | Zisoulis D G Kai Z S Chang R K | 2012 | Nature2012，486，7404： | 1 |
| 7 | Synthesis,characterization,and ceramic conversion reactions of borazine-modified hydridopolysilazanes:new polymeric precursors to silicon nitride carbide boride (SiNCB) ceramic composites显示文摘 | KAI S EDWARD E R GREGG A S | 1993 | Chem Mater1993，5，4： | 1 |
| 8 | Predictor of Asthma Three Years after Hospital Admission for Wheezing in Infancy显示文摘 | Tian M R Annek S Kai K | 2000 | J Pediatr2000，106，6： | 1 |
| 9 | n-Hexane neuropathy caused by addictive inhalation: clinical and electrophysiological features显示文摘 | KUWABARA S KAI M R NAGASE H | 1999 | Eur Neurol1999，41，3： | 1 |
| 10 | Evaluation of an automated hydrolysis and extraction method for quantification of total fat, lipid classes and trans fat in cere- al products显示文摘 | ROBINSON J E SINGH R KAYS S E | 2008 | Food Chemistry2008，107，： | 1 |
| 11 | Effects of training and representational characteristics in icondesign显示文摘 | Goonetilleke R S Martins Shih H Kai On H | 2001 | International Journal of Human-Computer Studies2001，55，5： | 1 |
| 12 | Small molecular inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct显示文摘 | Necula M Kayed R Milton S | 2007 | J Biol Chem2007，282，10： | 1 |
| 13 | Regulation of conidiation and adenylyl cyclase levels by the Get protein GNA-3 in Neurospora erassa显示文摘 | Kays A M Rowley P S Baasiri R A | 2000 | Molecular and Cellular Biology2000，20，： | 1 |
| 14 | Structural and dynamic features of Alzheim-er's Aβpeptide in amyloid fibrils studied by site-directed spin labeling显示文摘 | Tbrbk M Milton S Kayed R | 2002 | J Biol Chem2002，277，40： | 1 |
| 15 | Prediction of total dietary fiber in cereal products using near-infrared reflectance spectroscopy显示文摘 | Kays S E Windham W R | 1996 | Agriculture and Food Chenistry1996，44，8： | 1 |
| 16 | Tracking animal location and activity with an automated radio telemetry system in a tropical rainforest 显示文摘 | KAYS R TILAK S CROFOOT M | 2011 | Computer Journal2011，54，12： | 1 |
| 17 | Changes inα - andβ - amylase during storage of sweetpotato lines with varying starch hydrolysis potential 显示文摘 | Morrisona T A Pressey R Kays S T | 1993 | Journal of the American Society for Horticultural Science1993，118，2： | 1 |
| 18 | The gas diffusion layer in polymer electrolyte membrane fuel cells: a process model of the two phase flow 显示文摘 | Roberto L N Richard H R Michael M Kai S | 2011 | International Journal of Hydrogen Energy2011，36，16： | 1 |
| 19 | Pre- diction of Crystallographic Texture Evolution and Aniso- lropic Stress-strain Curves During Large Plastic Strains in High Purity a-titanium Using a Taylor-type CiTslal Plas- ticity Model显示文摘 | WU Xian-ping KAI ID1NDI S R NECKER C | 2007 | Acta Materialia2007，55，： | 1 |
| 20 | Prediction of total dietary fiber in cereal products using near-infrared reflectance spectroscopy显示文摘 | Kays S E Windham W R | 1996 | Agriculture and Food Chenistry1996，44，8： | 1 |
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