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| 1 | 神经节苷脂对神经母细胞瘤细胞粘附于胶原蛋白作用的影响显示文摘目的 以胶原蛋白 (CN)作为底物 ,探讨内生肿瘤神经节苷脂 (GS)对神经母细胞LA N5细胞株粘附功能的影响。方法 用葡萄糖苷神经酰氨合成酶抑制剂 (D PDMP)抑制LA N5细胞株GS合成 ,观察该细胞对包被CN粘附作用的变化。结果 暴露于D PDMP 6d后 ,细胞GS几乎完全清除 ,但细胞的活力、增殖率及凋亡率较对照组无明显变化 ;暴露于D -PDMP的细胞 ,其粘附能力仅为对照组的 3 5 % :OD570 分别为 0 .0 7± 0 .0 1和 0 .2 1± 0 .0 3 (P <0 .0 1)。用培养对照组LA N5细胞收集的条件培养液 (其中有细胞脱落的GS)和纯化的肿瘤GSGD2预处理已暴露于D PDMP的LA N5细胞 ,可恢复该细胞的粘附表型 ,较对照组差异无显着性 (P >0 .0 5 )。结论 内生肿瘤GS调节肿瘤细胞对CN的粘附作用 ,提示GS在肿瘤细胞的迁移 ,侵入和转移中可能起重要作用。 | 文飞球 陈亦欣 吴本清 Tamara Kazarian Leonard A.Valentino | 2001 | 中国当代儿科杂志2001，3，4： | 4 |
| 2 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 3 | Partitioning of solutes and cosolvents between supercritical CO2 and polymer phases显示文摘 | Sergei G Kazarian Michale F Vincent Barry L West | 1998 | Journal of Supercritical Fluids1998，13，： | 1 |
| 4 | Spectroscopy of polymer/drug formulations processed with supercritical fluids: In situ ATR-IR and Raman study of impregnation of ibuprofen into PVP 显示文摘 | Kazarian S G Martirosyan G G | 2002 | International Journal of Pharmaceutics2002，232，12： | 1 |
| 5 | Tip-enhanced Raman mapping with top-illumination AFM显示文摘 | Chan K L A Kazarian S G | 2011 | Nanotechnology2011，22，17： | 1 |
| 6 | Thermal properties of grains显示文摘 | Kazarian E A Hall C W | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 7 | Thermal properties of grains 显示文摘 | Kazarian E A Hall C W | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 8 | Reasons and prophylaxis of fa- tiguability of the visual analyzer in users of computer video-displays 显示文摘 | Kazarian EE Mamikonian VR | 2003 | Vestn Oftalmol2003，119，3： | 1 |
| 9 | In situ ATR-FTIR spcctroscopy of poly ( ethylene terephthalate) subjected to high-temperature methanol显示文摘 | ANDANSON J M KAZARIAN S G | 2008 | Macromolecular Sym- posium2008，265，： | 1 |
| 10 | Spectroscopy of polymer/drug formulations processed with supercritical fluids: in situ ATRIR and Raman study of impregnation of ibuprofen into PVP显示文摘 | Kazarian SG Martirosyan GG | 2002 | Int J Pharm2002，232，12： | 1 |
| 11 | A First in Human Phase 1 Study of CG0070, a GM-CSF Expressing Oncolytic Adenovirus, for the Treatment of Nonmuscle Invasive Bladder Cancer显示文摘 | James M. Burke Donald L. Lamm Maxwell V. Meng John J. Nemunaitis Joseph J. Stephenson James C. Arseneau Junko Aimi Seth Lerner Alex W. Yeung Troy Kazarian Daniel J. Maslyar James M. McKiernan | 2012 | The Journal of Urology2012，，6： | 1 |
| 12 | Effects of nifedipine and nicardipine on regional cerebral blood flow distributionin patients with arterial hypertension 显示文摘 | Simonian NA Kazarian AV | 1996 | Methods Find Exp Clin Pharmacol1996，18，10： | 1 |
| 13 | Core concepts: orthopedic intern curriculum boot camp 显示文摘 | Seeley MA Kazarian E King B | 2016 | Orthopedics2016，，： | 1 |
| 14 | Effect of nifidipine and nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension显示文摘 | Akopov SE Simonian NA Kazarian AV | 1996 | Methods Find Exp Clin Pharmacol1996，18，： | 1 |
| 15 | The parental bonding instrument: Factorial structure显示文摘 | Kazarian SS Baker B Helmes ET | 1987 | British Journal of Clinical Psychology1987，26，3： | 1 |
| 16 | In situ FTIR measurement of carbon dioxide sorption into poly(ethylene terephthalate) at elevated pressures显示文摘 | Noel H Brantley Sergei G Kazarian Charles A Eckert | 2000 | Journal of Applied Polymer Science2000，77，： | 1 |
| 17 | High pressure CO2-induced reduction of the melting temperature of ionic liquids显示文摘 | Kazarian S G Sakellarios N Gordon C M | 2002 | Chem Commun2002，12，： | 1 |
| 18 | Partitioning of solutes and cosolvents between supercritical CO2 and polymer phases显示文摘 | Sergei G Kazarian Michael F Vincent Barry L West | 1998 | Journal of Supercritical Fluids1998，13，： | 1 |
| 19 | Specific intermolecular interaction of carbon dioxide with polymers显示文摘 | Vincent M F Bright F V | 1996 | J Ame Chem Soc1996，118，： | 1 |
| 20 | Combining ionic liquids and supercritical fluids:In situ ATR-IR study of CO2 dissolved in two ionic liquidsathighpressures显示文摘 | Kazarian S G Briscoe B J | 2000 | Chem Commun2000，20，： | 1 |
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