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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Effects of simulated acidic rain on yields of field-grown crops显示文摘 | LNACE S E KEITH F L ELIZABETH A C | 1982 | New Phytol1982，91，： | 1 |
| 3 | Revisions to the ORNL series of adult and pediatric computational phantoms for use with the MIRD schema显示文摘 | EUN Y H WESLEY E B KEITH F E | 2006 | Health Phys2006，90，： | 1 |
| 4 | Effects of simulated acidic rain on yields of field- grown crops 显示文摘 | Lance S E Keith F L Elizabeth A C | 1982 | New Phytologist1982，91，： | 1 |
| 5 | How Changing the Focus of Attention Affects Performance, Kinematics, and Electromyography in Dart Throwing 显示文摘 | Keith R L David E S Alice F H | 2010 | Human Movement Science2010，29，： | 1 |
| 6 | Modeling Nitrate-Nitrogen Load Reduction Strategies for the Des Moines River, Iowa Using SWAT 显示文摘 | Keith E S Calvin F W | 2009 | Environmental Management2009，，44： | 1 |
| 7 | Digital control of active magnetic bearings显示文摘 | Williams R D Keith F J Allaire P E | 1990 | IEEE Transactions on Industrial Electronics1990，37，1： | 1 |
| 8 | Contribution of base flow to nonpoint source pollution loads in an agricultural watershed显示文摘 | Keith E S Calvin F W | | 0，，： | 1 |
| 9 | The scaling of a- coustic streaming for application in micro-fluidic de- vices显示文摘 | Kenneth D F Shawn E M Keith M | 2003 | Applied Acoustics2003，64，： | 1 |
| 10 | Nanofa- brieation with proximal probes 显示文摘 | Snow E S Campbell Pual M Perkins F Keith | 1997 | Proeeedings of the IEEE1997，85，4： | 1 |
| 11 | Rapid identification of pregnant women heavily colonized with group B streptococci显示文摘 | Douglas E J Elizbeth M F Keith S K | 1983 | Journal of clinical microbiology1983，18，3： | 1 |
| 12 | Digital control of active magnetic bearing 显示文摘 | Williams R D Keith F J Allaire P E | 1990 | IEEE Transactions on Industrial Electronics1990，37，1： | 1 |
| 13 | Modeling new adsorbents for ethylene-ethane separations by adsorption via π-complexation显示文摘 | Felipe J B Lourdes F V Keith E G | 1998 | Fluid Phase Equilibria1998，，： | 1 |
| 14 | Practical considerations in kinetic resolution reactions 显示文摘 | KEITH J M LARROW J F JACOBSEN E N | 2001 | AdvSynth Catal2001，343，1： | 1 |
| 15 | The academic research-teaching nexus in eight advanced-industrialized countries显示文摘 | Gottlieb E F Keith B | 1997 | Higher Education1997，，33： | 1 |
| 16 | Early bronchiolitis obliterans following lung transplantation; accuracy of expiratory thin-see- tion CT for diagnosis 显示文摘 | Lee E S Gotway M B Golden G P Golden J A Keith F M Webb W R | 2000 | Radiology2000，216，： | 1 |
| 17 | Digital control of active mag- netic bearings 显示文摘 | Williams R D Keith F J Allaire P E | 1990 | IEEE Transactions on Industrial Electronics1990，37，1： | 1 |
| 18 | Climate change effects on organic carbon storage in agricultural soils of Spain northeastern显示文摘 | Jorge A F Mark E Keith P | 2012 | Agriculture Ecosystems and Environment2012，155，： | 1 |
| 19 | Tumor necrosis factor-al- pha accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages显示文摘 | Redente E F Keith R C Janssen W | 2014 | Am J Respir Cell Mol Biol2014，50，4： | 1 |
| 20 | Genotoxicity of the benzene metabolites para-benzoquinone and hydroquinone显示文摘 | MARGARET G KEITH I E M PETER B F | 2005 | Chemico-Biological Interactions2005，153，1： | 1 |
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