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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 3 | The causes and diagnosis of influenza-like illness 显示文摘 | Kelly H Birch C | 2004 | Aust Fam Physician2004，33，5： | 1 |
| 4 | Proteases in parasitic diseases显示文摘 | McKerrow J H Caffrey C Kelly B | 2006 | Annu Rev Pathol2006，1，： | 1 |
| 5 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 6 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | The causes and diagnosis of influenza-like illness显示文摘 | Kelly H Birch C | 2004 | Aust Fam Physician2004，33，5： | 1 |
| 8 | Dispersion of cerussite-rich tailings and plant uptake of heavy metals at historical lead mines near Newtownards,Northern Ireland显示文摘 | Moles N R Smyth D Mather C E Beattie E H Kelly M | 2004 | Applied Earth Science2004，113，： | 1 |
| 9 | Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003 显示文摘 | Druce J Tran T Kelly H Kaye M Chibo D Kostecki R Amiri A Catton M Birch C | 2005 | J Med Virol2005，75，1： | 1 |
| 10 | Transformation toughening in zirconia-containing ceramics显示文摘 | HANNINK H J KELLY P M MUDDLE B C | 2000 | Journal of the American Ceramic Society2000，83，3： | 1 |
| 11 | Adozelesin,a selected lead among eyelopropapyrroloindole analogues of the DNA-binging antibiotic CC-1065 显示文摘 | Li L H Kelly R C Warpehowski M A | 1991 | Invest New Drugs1991，9，2： | 1 |
| 12 | Effect of pH on mercury uptake by an aquatic bacterium: Implications for Hg cycling 显示文摘 | Kelly C A Rudd J W Holoka M H | 2003 | Environmental Science and Technology2003，37，13： | 1 |
| 13 | Continuous Measurement of CO2 for Estimation of Air-water fluxes in Lakes: An In situ Technique 显示文摘 | SELLERS P HESSLEIN R H KELLY C A | 1995 | Limnology and Ocea- nography1995，40，3： | 1 |
| 14 | Low grade chronic inflammation in Women with PCOS显示文摘 | Kelly C C J Lyall H Petrie J R | 2001 | Clin Endocrinol Metab2001，86，6： | 1 |
| 15 | Cultivar,lower stage,silver thiosulfate and BA interactions affect performance of potted miniature roses显示文摘 | Cushman L C Pemberton H B Kelly J W | 1994 | HortScience1994，29，： | 1 |
| 16 | Prediction of gas- oline octane numbers by near infrared spectroscopy in the spectral range 680-1235 nm 显示文摘 | Kelly J J Barlow C H Jinguji T M | 1989 | Anal Chem1989，61，4： | 1 |
| 17 | The effects of filter-feeding clam Mercenaria mercenaria on carbon cycling in experimental marine mesocosms显示文摘 | Oviatt C A Kelly J R | 1986 | J Mar Res1986，44，： | 1 |
| 18 | A specific elevation in tissue plasminogen activator antigen in women with polycystic ovary syndrome 显示文摘 | Kelly C J Lyall H Petrie J R | 2002 | J Clin Endocrinol Metab2002，87，7： | 1 |
| 19 | Prediction of Gasoline Octane Numbers from Near-infrared Spectral Features in the Range 660 - 1215 nm显示文摘 | Kelly J J Barlow C H Jinguji T M | 1989 | Anal Chem1989，61，： | 1 |
| 20 | Functional role for c-Myc in mitogenic response to platelet-derived growth factor显示文摘 | Armelin H A Armelin M C S Kelly K | 1984 | Nature1984，310，： | 1 |
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