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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virol1998，72，11： | 1 |
| 4 | Field trials of suction caissons in clay for offshore wind turbine foundations 显示文摘 | Houlsby G T Kelly R B Huxtable J | 2005 | Geoteehnique2005，25，4： | 1 |
| 5 | A low-glycemic index diet combined with exercise reduces insulin resistance,postprandial hyperinsulinemia,and glucose-dependent insulinotropic polypeptide responses in obese,prediabetichumans显示文摘 | Solomon T P Haus J M Kelly K R | 2010 | Am J Clin Nutr2010，92，6： | 1 |
| 6 | Axillary lymph node metastases in patients with a final diagnosis nf ductal carcinoma in situ显示文摘 | Kelly T A Kim J A Patrick R | 2003 | Am J Surg2003，186，： | 1 |
| 7 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 8 | Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance显示文摘 | Haus JM Kashyap SR Kasumov T Zhang R Kelly KR Defronzo RA | 2009 | Diabetes2009，58，2： | 1 |
| 9 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Field trials of suction caissons in clay for offshore wind turbine foundations 显示文摘 | Houlsby G T Kelly R B Huxtable J | 2005 | Geotechnique2005，55，4： | 1 |
| 11 | Pathogenesis of hantaan virus infection in suckling mice:clinieal,virologic,and serologic observations显示文摘 | Gum R K Kelly T Mckee Jr | 1985 | Am J Trop Med Hyg1985，34，2： | 1 |
| 12 | Cardiac endothelium and tissue growth显示文摘 | Balligand J L Kelly R A Smith T W | 1997 | Prog Cardiovase Dis1997，39，4： | 1 |
| 13 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | | 0，，11： | 1 |
| 14 | Importance of microbial colonization of the gut in early life to the development of immunity显示文摘 | King T Aminov R | 2007 | Mutat Res2007，622，12： | 1 |
| 15 | Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003 显示文摘 | Druce J Tran T Kelly H Kaye M Chibo D Kostecki R Amiri A Catton M Birch C | 2005 | J Med Virol2005，75，1： | 1 |
| 16 | Supporting system of systems hazard analysis using muhi-agent simulation显示文摘 | Alexander R Kelly T | 2013 | Safety Science2013，51，1： | 1 |
| 17 | Importance of microbial colonization of the gut in early life to the development of immunity显示文摘 | Kelly D King T Aminov R | 2007 | Mutat Res2007，622，12： | 1 |
| 18 | A third-generation lentivirus vector with a conditional packaging system显示文摘 | Dull T Zufferey R Kelly M | 1998 | J Virol1998，72，11： | 1 |
| 19 | Flavonoid antioxida- nts: chemistry, metabolism and structure-activity relation- ships 显示文摘 | Kelly E H Anthony R T Dennis J B | 2002 | Nutritional Biochemistry2002，13，： | 1 |
| 20 | An overview of research using the one atmosphere uniform glow discharge plasma (OAUGDP) for sterilisation of surfaces and materials 显示文摘 | Montie T C Kelly Wintenberg K Roth J R | 2000 | IEEE Trans on Plasma Sci2000，28，1： | 1 |
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