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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 4 | Organizational inertia and momentum: A dynamic model of strategic change 显示文摘 | Kelly A Amburgey T L | 1991 | Academy of Management Journal1991，34，3： | 1 |
| 5 | Tourniquet safety in lower leg applications显示文摘 | MCEWEN J A KELLY D L JARDANOWSKI T | 2002 | Orthop Nurs2002，21，5： | 1 |
| 6 | Perovskite solar cells with a planar heterojunction structure prepared using roomtemperature solution processing techniques显示文摘 | LIU D KELLY T L | 2014 | Nature Photonics2014，8，2： | 1 |
| 7 | Activities and postantibiotic effects of gemifloxacin compared to those of 11 other agents against Haemophilus influenzae and Moraxella catarrhalis显示文摘 | Davies T A Kelly L M Hoellman D B | 2000 | Antimicrob Agents Chemother2000，44，3： | 1 |
| 8 | 查看详情显示文摘 | Regan S P Marozas J A Craxton R S Kelly J H Donaldson W R Jaanimagi P A Jacobs-Perkins D Keck R L Kessler T J Mey-erhofer D D Sangster T C Seka W Smalyuk V A Sknpsky S Zuegel J D | | 0，，： | 1 |
| 9 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Importance of the forest canopy to flux of methylmercury and total mercury to boreal ecosystems显示文摘 | Vincent L Louis S T John W M Kelly C A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 11 | Cardiac endothelium and tissue growth显示文摘 | Balligand J L Kelly R A Smith T W | 1997 | Prog Cardiovase Dis1997，39，4： | 1 |
| 12 | Classification comparisons between dual-pol,compact polarimetric and quad-pol SAR imagery显示文摘 | Ainsworth T L Kelly J P Lee J S | 2009 | ISPRS Journal of Photogrammetry and Remote Sensing2009，64，5： | 1 |
| 13 | The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration显示文摘 | KELLY S T OPONG W S ZYDNEY A L | 1993 | J Membr Sci1993，80，： | 1 |
| 14 | Dual en- ergy X-Ray absorptiometry body composition reference values from NHANES 显示文摘 | KELLY T L WILSON K E HEYMSFIELD S B | 2009 | PLoS ONE2009，4，9： | 1 |
| 15 | Spectrophotometic Determination of Cysteine and/or Carbocysteine in a Mixture of Amino Acid,Shampoo,and Pharmaceutical Product Using p-Benzoquinone显示文摘 | Dimas A M Kelly C L Cassia T B V | 1999 | Talanta1999，50，5： | 1 |
| 16 | Synthesis of Some Unsymmetrical Bridged Tcrpyridines显示文摘 | Kelly T R Lebedev R L | 2002 | J Org Chem2002，67，7： | 1 |
| 17 | Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics显示文摘 | Hefnawy T E Raja S Kelly L | 2004 | Clinical Chemistry2004，50，3： | 1 |
| 18 | Inhibition of human estrogen synthetase(aromatase) by flavones显示文摘 | Kellis J T Vickery L E | 1984 | Science1984，225，4666： | 1 |
| 19 | Characteriza- tion of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics 显示文摘 | EI-Hefnawy T Raja S Kelly L | 2004 | Clin Chem2004，50，3： | 1 |
| 20 | Perovskite solar cells with a planar heterojunction structure prepared using room-temperature solutionprocessing techniques 显示文摘 | Liu D and Kelly T L | 2013 | Nature Photonics2013，8，2： | 1 |
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