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| 1 | CONSORT 2010说明与详述:报告平行对照随机临床试验指南的更新显示文摘大量证据显示随机对照临床试验(randomised controlled trial,RCT)的报告质量不理想。报告不透明,则读者既不能评判试验结果是否真实可靠,也不能从中提取可用于系统综述的信息。最近的方法学分析表明,报告不充分和设计不合理与对治疗效果产生评价偏倚有关。这种系统误差对RCT损害严重,而RCT正是以其能减少或避免偏倚而被视为评价干预措施的金标准。为了提高RCT的报告质量,一个由专家和编辑组成的工作组制定了临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)声明。CONSORT声明于1996年首次发表,并于2001年更新。声明由对照检查清单和流程图组成,供作者在报告RCT时使用。许多核心医学期刊和主要国际性编辑组织都已认可CONSORT声明。该声明促进了对RCT的严格评价和解释。2001年,在对CONSORT进行修订时,人们就已经清楚地认识到,解释和说明制定CONSORT声明的原理,有助于研究人员等撰写或评价临床试验报告。一篇CONSORT说明与详述文章于2001年同2001版CONSORT声明一起发表。2007年1月的专家会议之后,对CONSORT声明作了进一步修订并已发表,即'CONSORT2010声明'。这次更新对原版对照检查清单作了文字上的修改,使其更为明晰,并收入了与一些新近才认识到的主题相关的建议,如选择性报告结局产生的偏倚。说明与详述文件旨在加强人们对CONSORT声明的理解、应用和传播,这次也作了大量修订,对每一项新增或更新的清单条目的含义和增改理由进行了解释,提供了优秀的报告实例,还尽可能地提供了相关的经验性研究的参考文献。文中收入了若干流程图实例。'CONSORT2010声明'、其说明与详述文件,以及相关网站(www.consort-statement.org),对于改进随机临床试验报告必将有所裨益。 | David Moher Sally Hopewell Kenneth F Schulz Victor Montori Peter C Gφtzsche P J Devereaux Diana Elbourne Matthias Egger Douglas G Altman 周庆辉 卞兆祥 刘建平 | 2010 | 中西医结合学报2010，8，8： | 318 |
| 2 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 3 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 4 | Predictive dynamic model of a small pressure swing adsorption air separation unit 显示文摘 | Kenneth G Teague J Thomas E | 1999 | Ind Eng Chem Res1999，38，10： | 1 |
| 5 | Alfalfa yield and quality as influenced by establishment method显示文摘 | Michael D H Kenneth J M Ronald G | 2002 | Agronomy Journal2002，94，1： | 1 |
| 6 | Nitrogen transfer from phaseolus bean to intercropped maize measured using 15N-enrichment and 15N-isotope dilution methods显示文摘 | Kenneth E G Ormesher J Awah F M | 1991 | Biochemistry1991，23，4： | 1 |
| 7 | The Mollary body morphological, clinical and experimental studies (part 1) of a literature survey显示文摘 | Kenneth J Christian G | 1994 | Hepatology1994，10，： | 1 |
| 8 | High-resolution image reconstruction from a sequence of rotated and translated frames and its application to an infrared imaging system显示文摘 | Russell C H Kenneth J B John G B | 1998 | Optical Engineering1998，37，1： | 1 |
| 9 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 10 | The Gelation and Crystallization of Amylopeetin 显示文摘 | Stephen G Ring Paul Colonna Kenneth J I' Anson | 1987 | Carbohydr Res1987，162，： | 1 |
| 11 | The utilization of risk assessments in tactical command decisions 显示文摘 | WARREN W J KENNETH R S G BRUCE B | 2002 | Sei Total Environ2002，288，： | 1 |
| 12 | A strategic framework for manufacturer reseller conflict 显示文摘 | ALLEN J MAGRATH KENNETH G HARDY | 1988 | Marketing Science Institute Report1988，，3： | 1 |
| 13 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry显示文摘 | OSCAR J C RUSSELL M W KENNETH G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，154： | 1 |
| 14 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry 显示文摘 | Oscar J C Russell M W Kenneth G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，，154： | 1 |
| 15 | Sputtered thin-film pH electrocles of platinum,palladiun,rutheniun,and iridiun oxides显示文摘 | Kenneth G Krerder Michael J Tarlor James P Cline | 1995 | Sensors and Actuators B1995，28，： | 1 |
| 16 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 17 | RFIDutilization and information sharing:the impact on supplychain performance显示文摘 | PAMELA J Z KENNETH W G VICTOR E S | 2010 | Journal of business and industrialmarketing2010，25，8： | 1 |
| 18 | Comparison of the effica-cies of loopmediated isothermal amplification,fluorescence smearmicroscopy and culture for the diagnosis of tuberculosis显示文摘 | GEORGE G MONY P KENNETH J | 2011 | PLoSOne2011，6，6： | 1 |
| 19 | Pulsed laser deposition of mesoporous niobium oxide thin films and application as chemical sensors 显示文摘 | MARY E G KENNETH J B | 1999 | Microporous and Mesoporous Materials1999，28，1： | 1 |
| 20 | Carbon monitoring costs and their effect on incentives to sequester carbon through forestry显示文摘 | Oscar J C Russell M W Kenneth G M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，154，： | 1 |
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