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| 1 | Visceral hypersensitivity and altered colonic motility after subsidence of inflammation in a rat model of colitis显示文摘AIM: Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by visceral hypersensitivity and altered bowel motility. There is increasing evidence suggesting the role of inflammation in the pathogenesis of IBS, which addresses the possibility that formerly established rat model of colitis could be used as an TBS model after the inflammation subsided.METHODS: Colitis was induced by intracolonic instillation of 4 % acetic acid in male Sprague-Dawley rats. The extent of inflammation was assessed by histological examination and myeloperoxidase (MPO) activity assay. After subsidence of colitis, the rats were subjected to rectal distension and restraint stress, then the abdominal withdrawal reflex and the number of stress-induced fecal output were measured,respectively.RESULTS: At 2 days post-induction of colitis, the colon showed characteristic inflammatory changes in histology and 8-fold increase in MPO activity. At 7 days post-induction of colitis, the histological features and MPO activity returned to normal. The rats at 7 days post-induction of colitis showed hypersensitive response to rectal distension without an accompaning change in rectal compliance, and defecated more stools than control animals when under stress.CONCLUSION: These results concur largely with the characteristic features of IBS, visceral hypersensitivity and altered defecation pattern in the absence of detectable disease, suggesting that this animal model is a methodologically convenient and useful model for studying a subset of IBS. | Jun-Ho La Tae-Wan Kim Tae-Sik Sung Jeoung-Woo Kang Hyun-Ju Kim ⅠI-Suk Yang | 2003 | World Journal of Gastroenterology2003，9，12： | 57 |
| 2 | Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats显示文摘AIM:To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. METHODS:We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. RESULTS:Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 μg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 μg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. CONCLUSION:These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis. | Jun-Ho La Tae-Sik Sung Hyun-Ju Kim Tae-Wan Kim Tong Mook Kang Il-Suk Yang | 2008 | World Journal of Gastroenterology2008，14，5： | 15 |
| 3 | Refractive errors in high myopic eyes after phacovitrectomy for macular hole显示文摘AIM: To examine the refractive prediction error in high myopic eyes after phacovitrectomy.METHODS: This retrospective comparative case series included 91 eyes(18 high myopic eyes and 73 non-high myopic eyes) of 91 patients who underwent successful phacovitrectomy(phacoemulsification, intraocular lens implantation, and pars plana vitrectomy). The high myopic eyes were defined as the eye with more than 26.0mm of axial length. The postoperative prediction error of mean error and mean absolute error were evaluated at4 mo postoperatively. Axial length and keratometry measurement were performed preoperatively and 4mo postoperatively using the IOL Master.RESULTS: The refractive outcome after phacovitrectomy showed significantly greater myopic shift in the high myopic eyes [-1.08 ±0.87 diopters(D)] than that in the non-high myopic eyes(-0.43 ±0.63 D, P =0.004). Axial length and keratometric value in the high myopic eyes were significantly increased(P =0.043, 0.037 respectively),whereas those in the non-high myopic group were not significantly increased(P =0.135, 0.347 respectively). The change of the axial length in the myopic eye(0.46±0.28 mm)was greater than that in the non- high myopic eye(0.11 ± 0.34 mm; P <0.001).CONCLUSION: High myopic eyes showed more myopic shift than non-high myopic eyes after phacovitrectomy.The cause of myopic shift in high myopic eyes seems tobe attributed to actual elongation of the axial length in high myopia. | Donghyun Jee Yi-Ryeung Park Kyoung In Jung Eunchul Kim Tae Yoon La | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 9 |
| 4 | Increase in neurokinin-1 receptor-mediated colonic motor response in a rat model of irritable bowel syndrome显示文摘AIM: Irritable bowel syndrome (IBS) is a functional bowel disorder. Its major symptom is bowel dysmotility, yet the mechanism of the symptom is poorly understood. Since the neurokinin-1 receptor (NK1R)-mediated signaling in the gut is important in the control of normal bowel motor function,we aimed to investigate whether the NK1R-mediated bowel motor function was altered in IBS, using a rat IBS model that was previously reported to show colonic dysmotility in response to restraint stress.METHODS: IBS symptoms were produced in male SpragueDawley rats by inducing colitis with acetic acid. Rats were left to recover from colitis for 6 d, and used for experiments 7 d post-induction of colitis. Motor activities of distal colon were recorded in vitro.RESULTS: The contractile sensitivity of isolated colon to a NK1R agonist [Sar9, Met(O2)11]-substance P (1-30 nmol/L)was higher in IBS rats than that in normal rats. After the enteric neurotransmission was blocked by tetrodotoxin (TTX, 1 μmol/L), the contractile sensitivity to the NK1R agonist was increased in normal colon but not in IBS rat colon. The NK1R agonist-induced contraction was not different between the two groups when the agonist was challenged to the TTX-treated colon or the isolated colonic myocytes. A nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME, 100 μmol/L) augmented the NK1R agonist-induced contraction only in normal rat colon.CONCLUSION: These results suggest that the NK1R-meidated colonic motor response is increased in IBS rats, due to the decrease in the nitrergic inhibitory neural component. | Jun-Ho La Tae-Wan Kim Tae-Sik Sung Hyn-Ju Kim Jeom-Yong Kim Il-Suk Yang | 2005 | World Journal of Gastroenterology2005，11，2： | 7 |
| 5 | Treatment of intractable orbital implant exposure with a large conjunctival defect by secondary insertion of the implant after preceding dermis fat graft显示文摘AIM: To report a procedure and results of a two-stage operation to manage intractable extensive orbital implant exposure with a large conjunctival defect which was difficult to treat with dermis fat grafts due to repeated graft necrosis. METHODS: A retrospective chart review of four patients who had extensive orbital implant exposures with large conjunctival defects and had past histories of repeated autologous or preserved dermis graft failures was done. As a first-stage operation, the problematic pre-existing orbital implants were removed and autologous dermis fat grafts alone were performed on the defect area. Four months later, new orbital implants were secondarily inserted after confirmation of graft survival. The size of the conjunctival defects and state of the extraocular muscles were checked preoperatively. Success of the operations and complications were investigated.RESULTS: The mean size of the conjuctival defects was 17.3mm×16.0mm, and the mean time from the initial diagnosis of orbital implant exposure to implant removal and autologous dermis fat graft was 20.8 months. After implant removal and autologous dermis fat graft, no graft necrosis was observed in any patients. Also, implant exposure or fornix shortening was not observed in any patients after new orbital implant insertion. CONCLUSION: The secondary insertion of a new orbital implant after pre-existing implant removal and preceding dermis fat graft is thought to be an another selective management of intractable orbital implant exposure in which dermis fat grafts persistently fail. | Hyun Kyung Kim Tae Yoon La | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 4 |
| 6 | Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)显示文摘 | George G. Zhanel Tamiko L. Hisanaga Nancy M. Laing Melanie R. DeCorby Kim A. Nichol Barb Weshnoweski Jack Johnson Ayman Noreddin Don E. Low James A. Karlowsky Daryl J. Hoban | 2006 | International Journal of Antimicrobial Agents2006，，6： | 2 |
| 7 | SAFETY AND EFFICACY OF PARTIAL NEPHRECTOMY FOR ALL T1 TUMORS BASED ON AN INTERNATIONAL MULTICENTER EXPERIENCE显示文摘 | JEAN-JACQUES PATARD OLEG SHVARTS JOHN S. LAM ALLAN J. PANTUCK HYUNG L. KIM VINCENZO FICARRA LUCA CINDOLO KEN-RYU HAN ALEXANDRE DE LA TAILLE JACQUES TOSTAIN WALTER ARTIBANI CLAUDE C. ABBOU BERNARD LOBEL DOMINIQUE K. CHOPIN ROBERT A. FIGLIN PETER F.A. MULDE | 2004 | The Journal of Urology2004，，6： | 2 |
| 8 | Family history of diabetes as a potential public health tool显示文摘 | Harrison TA Hindorff LA Kim H | 2003 | Am J Prev Med2003，24，2： | 1 |
| 9 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 10 | Hyperuricemia and incident hypertension:a systematic review and meta-analysis显示文摘 | Grayson PC Kim SY La Valley M | 2011 | Arthritis Care Res(Hoboken)2011，63，： | 1 |
| 11 | CD8+ T Lymphocytes Regulate the Arteriogenic Response to Ischemia by Infiltrating the Site of Collateral Vessel Development and Recruiting CD4+ Mononuclear Cells Through the Expression of Interleukin-16显示文摘 | Eugenio Stabile Timothy Kinnaird Andrea la Sala Sue Kim Hanson Craig Watkins Umberto Campia Matie Shou Stephan Zbinden Shmuel Fuchs Hardy Kornfeld Stephen E. Epstein Mary Susan Burnett | 2006 | Circulation2006，，1： | 1 |
| 12 | Phantom float显示文摘 | KIM K DE LA GARZA J M | 2003 | Journal of Construction Engineering and Management2003，129，5： | 1 |
| 13 | Alteration of nitrergic neuromuscular transmission as a result of acute expermental colitis in rat显示文摘 | Sung TS La JH Kim Tw | 2006 | J Veteri Sci2006，7，2： | 1 |
| 14 | Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation显示文摘 | La Z Hardt J Kim JJ | 2008 | Mol Hum Reprod2008，14，6： | 1 |
| 15 | IL-32,a proinflammatory cytokine in rheumatoid arthritis显示文摘 | Joosten LA Netea MG Kim SH | 2006 | Proc Natl Acad Sci U S A2006，103，9： | 1 |
| 16 | Evaluation of the resource-constrained critical path method algorithms显示文摘 | KIM K DE LA GARZA J M | 2005 | Journal of Construction Engineering and Management2005，131，5： | 1 |
| 17 | 查看详情显示文摘 | La K W Jung J C Kim H Baeck S H Song I K | | 0，，： | 1 |
| 18 | The inhibitory effect of apigenin on the agonist-induced regulation of vascular contractility via calcium desensitization-related pathways 显示文摘 | Je HD Kim HD La HO | 2014 | Biomol Ther (Seoul)2014，22，2： | 1 |
| 19 | A randomized controlled trial of growth hormone in active pediatric Crohn disease 显示文摘 | Denson LA Kim MO Bezold R | 2010 | J Pediatr Gastroenterol Nutr2010，51，2： | 1 |
| 20 | Visceral hypersensitivity antt altered co- Ionic nmtility 'after subsidence of inflammation in a ral model of colitis 显示文摘 | La JH Kim TW Sung TS | 2003 | World J Gastroentero12003，9，12： | 1 |
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