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| 1 | Influence of social isola- tion in the rat on serotonergic function and memory--rele- vance to models of schizophrenia and the role of 5-HT6 re- ceptors显示文摘 | Marsden CA King MV Fone KC | 2011 | Neuropharmacology2011，61，3： | 1 |
| 2 | A role for the 5-HTIA ,5-HT4 and 5-HT6 receptors in learning and memory显示文摘 | King MV Maisden CA Fone KC | 2008 | Trends Hiarmacoi Sci2008，29，9： | 1 |
| 3 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 4 | A comparison of cytology and fluorescence in situ hybridization for the detection ofurothelial carcinoma 显示文摘 | Hailing KC King W Sokolova IA eta/ | 2000 | J Urol2000，164，5： | 1 |
| 5 | A comparison of cytology and fluorescence in situ hybridization for the detec- tion of urothelial carcinoma显示文摘 | Halling KC King W Sokolova IA | 2000 | J Urol2000，164，5： | 1 |
| 6 | A comparison of cytology and fluorescence in situ hybridization for the detection of urothelial carcinoma 显示文摘 | Halling KC King W Sokolova IA | 2000 | J Urol2000，164，5： | 1 |
| 7 | Risk factors of enterovirus 71 infection and associated hand,foot,and mouth disease herpangina in children during an epidemic in Taiwan显示文摘 | Chang LY King CC Hsu KH Ning HC Tsao KC Li CC | 2002 | Pediatrics2002，109，6： | 1 |
| 8 | A comparison of BTA stat, hemoglobin dipstick, telomerase and Vysis UroVysion assays for the detection of urothelial carcinoma in urine 显示文摘 | Hailing KC King W Sokolova IA | 2002 | J Uml2002，167，： | 1 |
| 9 | A role for the 5 - HT1A, 5 - HT4 and 5 - HT6 receptors in learning and memory 显示文摘 | King MV Marsden CA Fone KC | 2008 | Trends Pharmacol Sci2008，29，9： | 1 |
| 10 | Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan 显示文摘 | Chang LY King CC Hsu KH Ning HC Tsao KC Li CC Hnang YC Shih SR Chiou ST Chen PY Chang HJ Ein TY | 2002 | Pediatrics2002，109，6： | 1 |
| 11 | A role for the 5-HT(1 A),5-HT4 and 5-HT6 receptors in learning and memory显示文摘 | King MV Marsden CA Fone KC | 2008 | Trends Pharmacol Sci2008，29，9： | 1 |
| 12 | A comparison of BTA stat,hemoglobin dipstick,telomerase and Vysis UroVysion assays for the detection of urothelial carcinoma in urine显示文摘 | Halling KC King W Sokolova IA | 2002 | J Urol2002，167，： | 1 |
| 13 | IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of sever pulmonary disease 显示文摘 | Fairfax KC Amiel E King IL | 2012 | PLoS Pathog2012，8，10： | 1 |
| 14 | A comparison of cytology and fluorescence in situ hybridization for the detection of urothelial carcinoma显示文摘 | Halling KC King W Sokolova IA | 2000 | J Urol2000，164，： | 1 |
| 15 | A comparison of cytology and fluorescence in situ hybridization for the detection of urotheli- al carcinoma显示文摘 | Hailing KC King W Sokolova IA | 2000 | J Urol2000，164，5： | 1 |
| 16 | IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease 显示文摘 | Fairfax KC Amiel E King IL | 2012 | PLoS Pathog2012，8，10： | 1 |
| 17 | A comparison of BTA star, hemoglobin dipstick, telomerase and Vysis UroVysion assays for the detection of urothelial carcinoma in urine显示文摘 | Hailing KC King W Sokolova IA et aI | 2002 | J Urol2002，167，5： | 1 |
| 18 | Comparative evaluation of the acute toxic effects in monkeys,pigs and mice of a genetically engineered Salmonella strain(VNP20009)being developed as an antitumor agent显示文摘 | King I Lee KC Zheng LM | 2000 | Int J Toxicol2000，19，1： | 1 |
| 19 | A comparison of cytology and fluorescence in situ hybridization for the detec- tion of urotheliai carcinoma 显示文摘 | Hailing KC King W Sokolova IA et ai | 2000 | J Urol2000，164，5： | 1 |
| 20 | Fibrous polyps of the ureter显示文摘 | Davides KC King LM | 1976 | J Urol1976，115，： | 1 |
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