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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | 星形胶质细胞通过分泌IL-23促进黑色素瘤脑转移显示文摘黑色素瘤是最主要皮肤致死性恶性肿瘤,黑色素瘤患者死亡的主要原因是远处转移,常为脑转移。微环境在肿瘤的发生和转移中起着关键的作用,为了治疗或预防转移,必须阐明播散的肿瘤细胞与转移性器官微环境之间的相互作用。然而,大脑间质细胞在促进转移性生长中的作用却知之甚少。星形胶质细胞的主要功能是大脑损伤后修复和形成胶质瘢痕,部分因为通过介导神经炎症,但是星形胶质细胞在黑色素瘤脑转移中的作用却不清楚。 | Klein A Schwartz H Sagi-Assif O 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 4 |
| 3 | Resveratrol Does Not Benefit Patients with Non-alcoholic Fatty Liver Disease显示文摘 | Veronique S. Chachay Graeme A. Macdonald Jennifer H. Martin Jonathan P. Whitehead Trisha M. O’Moore-Sullivan Paul Lee Michael Franklin Kerenaftali Klein Paul J. Taylor Maree Ferguson Jeff S. Coombes Gethin P. Thomas Gary J. Cowin Carl M.J. Kirkpatrick Joh | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 4 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 5 | High-power multistage Rankine cycles显示文摘 | IBRAHIM O M KLEIN S A | 1995 | ASME Trans J Energy Res Tech1995，117，3： | 1 |
| 6 | Albumin-bound basal insulin analogues (insulin detemir and NN344):comparable time-action profiles but less variability than insulin glargine in type 2 diabetes显示文摘 | Klein O Lynge J Endahl L | | 0，，： | 1 |
| 7 | BiOhemical factors underlying the age - related sensitivity of turkeys to aflatoxin B1显示文摘 | Klein P J Van - Vleet T R Hall J O | | 0，，： | 1 |
| 8 | Lo- cal and systemic risk factors influencing the long-term success of angular stable alloplastic reconstruction plates of the mandi- ble显示文摘 | KAMMERER P W KLEIN M O MOERGEL M | 2014 | Journal of Cranio-maxillo-facial Surgery: Official Pub- lication of the European Association for Cranio-Maxillo-Facial Surgery2014，42，5： | 1 |
| 9 | Genetic heterogeneity of single disseminated turnout cells in minimal residual cancer显示文摘 | Klein C A Blankenstein T J Schmidt-Kittler O Petronio M Polzer B Stoecklein N H | 2002 | Lancet2002，2360，： | 1 |
| 10 | Activation of nitroaldol reactions by diethylzinc and amino alcohols or diamines as promoters显示文摘 | Klein G Pandiaraju S Reiser O | 2002 | Tetrahedron Lett2002，43，42： | 1 |
| 11 | Radiation and convection-driven transient heat transfer during sublimation growth of silicon carbide single crystals 显示文摘 | KLEIN O PHILIP P SPREKELS J | 2001 | Journal of Crystal Growth2001，222，4： | 1 |
| 12 | AGA technical review on parenteral nutrition 显示文摘 | Koretz R L Lipman T O Klein S | 2001 | Gastroenterology2001，121，5： | 1 |
| 13 | Speed choice and driving performance in simulated foggy conditions显示文摘 | Brooks J O Crisler M C Klein N | 2011 | Accident Analysis and Prevention2011，43，3： | 1 |
| 14 | Organizational socialization:Its content and consequences 显示文摘 | Chao G T O' Leary-Kelly A M Wolf S Klein H J Gardner P D | 1994 | Journal of Applied Psychol- ogy1994，79，5： | 1 |
| 15 | , Functionalized silicon quantum dots tailored for targeted siRNA delivery显示文摘 | KLEIN S ZOLK O FROMM M F | 2009 | Biechem Biophys Res Com- mun2009，387，： | 1 |
| 16 | Bound Water in Shaly Sands-Its Relation to Qv and Other Formation Properties显示文摘 | Hill H J Shirley O J Klein G E | 1979 | The Log Analyst1979，20，3： | 1 |
| 17 | Chemosensitivity of B cell chronic lymphocytic leukemia and correlated expression of proteins regula- ting apoptosis, cell cycle and DNA repair显示文摘 | Klein A Micra O Bauer O | 2000 | Leukemia2000，14，1： | 1 |
| 18 | The diagnostic sensitivity of electrophysiologic testing in patients with syncope caused by transient bradycardia显示文摘 | Fujimura O Yee R Klein G | 1989 | N Engl J Med1989，321，25： | 1 |
| 19 | Sorption of nonpolar compounds to soil: processes, measurements and experience with the applicability of the modified OECE-Guideline 106 显示文摘 | Von O B Kordel W Klein W | 1991 | Chemosphere1991，22，： | 1 |
| 20 | Extensive MHC variability in cichlid fishes on Lake Malwi显示文摘 | Klein D Ono H O'huigin C | | 0，，： | 1 |
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