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| 1 | 经支气管针吸活检术在呼吸系统疾病诊治中的应用显示文摘经支气管针吸活检术( transbronchial needle aspiration,TBNA)是一种获取气道壁、肺实质以及邻近支气管树纵隔内病变部位的细胞学、组织学或微生物学标本的技术。自上世纪50年代阿根廷医生Schieppatti将硬质气管镜应用于临床以来,一直未能在临床上得到应用,直到80年代初将此技术应用于可弯曲支气管镜后,才在临床广泛开展,并在纵隔及肺门肿大淋巴结的诊断及鉴别诊断、肺癌的早期诊断和分期、 | 荣福 李强 Ko Pen Wang | 2008 | 中华结核和呼吸杂志2008，31，1： | 12 |
| 2 | Towards a natural classification of Botryosphaeriales显示文摘The type specimens of Auerswaldia,Auerswaldiella,Barriopsis,Botryosphaeria,Leptoguignardia,Melanops,Neodeightonia,Phaeobotryon,Phaeobotryosphaeria,Phyllachorella,Pyrenostigme,Saccharata,Sivanesania,Spencermartinsia and Vestergrenia were examined and fresh specimens of Botryosphaeriales were collected from Thailand.This material is used to provide a systematic treatment of Botryosphaeriales based on morphology and phylogeny.Two new genera,Botryobambusa and Cophinforma are introduced and comparedwith existing genera.Four species newto science,Auerswaldia dothiorella,A.lignicola,Botryosphaeria fusispora and Phaeobotryosphaeria eucalypti,are also described and justified.We accept 29 genera in Botryosphaeriales,with Macrovalsaria being newly placed.In the phylogenetic tree,the 114 strains of Botyrosphaeriales included in the analysis cluster into two major clades with 80%,96%and 1.00(MP,ML and BY)support,with Clade A containing the family type of Botryosphaeriaceae,and Clade B containing Phyllosticta,Saccharata and Melanops species.This group may represent Phyllostictaceae.In Clade A the taxa analyzed cluster in eight sub-clades(Clades A1-8).Clade A1 comprises three distinct subclusters corresponding to the genera Diplodia(Diplodia Clade),Neodeightonia(Neodeightonia Clade)and Lasiodiplodia(Lasiodiplodia Clade).Clade A2 clusters into three groups representing Phaeobotryosphaeria(100%),Phaeobotryon(100%)and Barriopsis(94%).Clade A3 incorporates 17 strains that cluster into three well-supported genera(Dothiorella(86%),Spencermartinsia(100%)and Auerswaldia(63%);the position of Macrophomina is not stable.Clade A4 is a single lineage(100%)representing the new genus Botryobambusa.Clade A5 is a wellsupported subclade incorporating Neofussicoccum.Clade A6 represents the type species of Botryosphaeria,three other Botryosphaeria species and two other genera,Neoscytalidium and Cophinforma gen.nov.Clade A7 comprises two Pseudofusicoccum species and Clade A8 has two Aplosporella species.These sub-clades may eventually require separate families but this requires analysis of a much larger dataset.Our data advances the understanding of Botryosphaeriales,there is,however,still much research to be carried out with resolution of families and genera,linkage of sexual and asexual morphs and differentiation of cryptic species. | Jian-Kui Liu Rungtiwa Phookamsak Mingkhuan Doilom Saowanee Wikee Yan-Mei Li Hiran Ariyawansha Saranyaphat Boonmee Putarak Chomnunti Dong-Qin Dai Jayarama D.Bhat Andrea I.Romero Wen-Ying Zhuang Jutamart Monkai E.B.Gareth Jones Ekachai Chukeatirote Thida Win Ko Ko Yong-Chang Zhao Yong Wang Kevin D.Hyde | 2012 | Fungal Diversity2012，，6： | 4 |
| 3 | Dopaminergic effects on in vitro osteogenesis显示文摘Multiple growth factors(e.g., BMP2, TGF-b1, FGF2) and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine(PDA) and dopamine(DA) monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA's role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. m RNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression(ALP, BSP, OC, OSX, RUNX2, and Collagen1a2) with or without receptor antagonists(SCH233390 and GR103691). Two-way ANOVA was used for statistical analysis. All five DA receptors(D1, D2, D3, D4, and D5) m RNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days(P, 0.05). Osteogenic mineralization was significantly greater in the DA-treated group than control group(P, 0.05). Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair. | Dong Joon Lee Henry C Tseng Sing Wai Wong Zhengyan Wang Meng Deng Ching-Chang Ko | 2015 | Bone Research2015，3，3： | 3 |
| 4 | Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species显示文摘瞄准:对 H 2 O 2-induced 汉语仓鼠肺成纤维细胞(V79-4 ) 损坏。方法:激进的清除活动被 1,1-diphenyl-2-picrylhydrazyl (DPPH ) 估计基,氢氧根激进分子,和细胞内部的反应的氧种类(ROS ) 。另外,类脂化合物每氧化是由与 thiobarbituric 酸反应的相关物质的措施的 assayed。在蛋白质的羰基形成的数量用一个蛋白质羰基 ELISA 工具包被决定。也,细胞的 DNA 损坏被西方的污点和免疫荧光图象检测。房间生存能力被 3-(4,5-dimethylthiazole-2-yl ) 估计 -2,5-diphenyltetrazolium 溴化物试金。结果:Esculetin 展出了 DPPH 基清除,清除的氢氧根激进分子,和细胞内部的 ROS 清除活动。esculetin 的激进的清除活动每 H 2 O 2 。因此, esculetin 恢复了暴露于 H 2 O 2 。结论:Esculetin 高效地稀释了氧化压力经由它的抗氧化剂性质的导致的房间损坏。作为结果, esculetin 可能在功能的食物的发展和药的原料是有用的。 | So-hyung KIM Kyoung-ah KANG Rui ZHANG Mei-jing PIAO Dong-ok KO Zhi-hong WANG Sung-wook CHAE Sam-sik KANG Keun-hwa LEE Hee-kyoung KANG Hyun-wook KANG Jin-won HYUN | 2008 | Acta Pharmacologica Sinica2008，29，11： | 3 |
| 5 | A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection显示文摘Interleukin-17(IL-17),a member of the IL-17 cytokine family,plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung.Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections,little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection.In this study,we show that H5N1-infected IL-17 knockout(KO)mice exhibit markedly increased weight loss,more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls.Moreover,the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection,which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice.Consistent with this observation,B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture.Taken together,these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. | Xiaohui Wang Chris CS Chan Min Yang Jun Deng Vincent KM Poon Virtual HC Leung King-Hung Ko Jie Zhou Kwok Yung Yuen Bo-Jian Zheng Liwei Lu | 2011 | Cellular & Molecular Immunology2011，8，6： | 2 |
| 6 | Current status and trends in forest genomics显示文摘Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human use.However,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest degradation.Forest genomics has great potential of increasing forest productivity and adaptation to the changing climate.In the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression data.These technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and variations.In this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each area.Evidently,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge. | Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing Fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei | 2022 | Forestry Research2022，2，1： | 2 |
| 7 | Field observations of rain-wind-induced cable vibration in cable-stayed Dongting Lake Bridge显示文摘 | Y.Q. Ni X.Y. Wang Z.Q. Chen J.M. Ko | 2006 | Journal of Wind Engineering & Industrial Aerodynamics2006，，5： | 2 |
| 8 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 9 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 10 | A molecular framework for seasonal growth-dormancy regulation in perennial plants显示文摘The timing of the onset and release of dormancy impacts the survival,productivity and spatial distribution of temperate horticultural and forestry perennials and is mediated by at least three main regulatory programs involving signal perception and processing by phytochromes(PHYs)and PHY-interacting transcription factors(PIFs).PIF4 functions as a key regulator of plant growth in response to both external and internal signals.In poplar,the expression of PIF4 and PIF3-LIKE1 is upregulated in response to short days,while PHYA and PHYB are not regulated at the transcriptional level.Integration of light and environmental signals is achieved by gating the expression and transcriptional activity of PIF4.During this annual cycle,auxin promotes the degradation of Aux/IAA transcriptional repressors through the SKP–Cullin-F–boxTIR1 complex,relieving the repression of auxin-responsive genes by allowing auxin response factors(ARFs)to activate the transcription of auxin-responsive genes involved in growth responses.Analyses of transcriptome changes during dormancy transitions have identified MADS-box transcription factors associated with endodormancy induction.Previous studies show that poplar dormancy-associated MADS-box(DAM)genes PtMADS7 and PtMADS21 are differentially regulated during the growth-dormancy cycle.Endodormancy may be regulated by internal factors,which are specifically localized in buds.PtMADS7/PtMADS21 may function as an internal regulator in poplar.The control of flowering time shares certain regulatory hierarchies with control of the dormancy/growth cycle.However,the particularities of different stages of the dormancy/growth cycle warrant comprehensive approaches to identify the causative genes for the entire cycle.A growing body of knowledge also indicates epigenetic regulation plays a role in these processes in perennial horticultural and forestry plants.The increased knowledge contributes to better understanding of the dormancy process and consequently to precise manipulation of dormancy-related horticultural traits,such as flowering time. | Donghwan Shim Jae-Heung Ko Won-Chan Kim Qijun Wang Daniel E Keathley Kyung-Hwan Han | 2014 | Horticulture Research2014，1，1： | 2 |
| 11 | The expression of porcine adiponectin and stearoyl coenzyme Adesaturase genes in differentiating adipocyte 显示文摘 | Wang P H Ko Y H B Liu H H | 2004 | J Anita Sci2004，17，： | 1 |
| 12 | Evaluation of antiseptic -impregnated central venous catheters for prevention of catheter -related infection in intensive care unit patients显示文摘 | Sheng WH Ko WJ Wang JT | 2000 | Diagn Microbiol Infect Dis2000，38，1： | 1 |
| 13 | Intrinsic Neutral and Anionic Structures of Glutathione 显示文摘 | Ko Y J Wang H Li X | 2009 | Chem Phys Chem2009，10，： | 1 |
| 14 | Extracorporeal shockwave for hip necrosis in systemic lupus erythematosus显示文摘 | Wang CJ Ko JY Chan YS | 2009 | Lupus2009，18，12： | 1 |
| 15 | Desmoid tumor of the head and neck 显示文摘 | Wang C P Chang Y L Ko J Y | 2006 | Head Neck2006，28，11： | 1 |
| 16 | Minocycline and cefotaxime in the treatment of experimental murine Vibrio vulnificus infection显示文摘 | Chuang Y C Ko W C Wang S T | 1998 | Antimicrob Agents Chemother1998，42，61： | 1 |
| 17 | The Gln-Argl91 polymorphism of the human paraoxonase gene is not associated with the risk of coronary artery disease among Chinese in Taiwan 显示文摘 | Ko YL Ko YS Wang SM | 1998 | Atherosclerosis1998，141，2： | 1 |
| 18 | Dual and opposing roles of ERK in regulating G1 and S - G2/M delays in A549 cells caused by hyperoxia 显示文摘 | Ko JC Wang YT Yang JL | 2004 | Exp Cell Res2004，297，2： | 1 |
| 19 | Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees 显示文摘 | Weng LH Wang CJ Ko JY | 2010 | Arthritis Rheu-US2010，62，13： | 1 |
| 20 | Minocycline and cefotaxime in the treatment of experimental murine Vibrio vulnificus infection显示文摘 | Chuang Y C Ko W C Wang S T | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
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