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| 1 | Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients显示文摘AIM:To investigate the comparative effect of laparoscopic and open cholecystectomy in elderly patients.METHODS:Laparoscopic cholecystectomy has induced a revolution in the treatment of gallbladder disease.Nevertheless,surgeons have been reluctant to implement the concepts of minimally invasive surgery in older patients.A systematic review of Medline was embarked on,up to June 2013.Studies which provided outcome data on patients aged 65 years or older,subjected to laparoscopic or open cholecystectomy were considered.Mortality,morbidity,cardiac and pulmonary complications were the outcome measures of treatment effect.The methodological quality of selected studies was appraised using valid assessment tools.Τhe random-effects model was applied to synthesize outcome data.RESULTS:Out of a total of 337 records,thirteen articles(2 randomized and 11 observational studies)reporting on the outcome of 101559 patients(48195in the laparoscopic and 53364 in the open treatment group,respectively)were identified.Odds ratios(OR)were constantly in favor of laparoscopic surgery,in terms of mortality(1.0%vs 4.4%,OR=0.24,95%CI:0.17-0.35,P<0.00001),morbidity(11.5%vs 21.3%,OR=0.44,95%CI:0.33-0.59,P<0.00001),cardiac(0.6%vs 1.2%,OR=0.55,95%CI:0.38-0.80,P=0.002)and respiratory complications(2.8%vs 5.0%,OR=0.55,95%CI:0.51-0.60,P<0.00001).Critical analysis of solid study data,demonstrated a trend towards improved outcomes for the laparoscopic concept,when adjusted for age and co-morbid diseases.CONCLUSION:Further high-quality evidence is necessary to draw definite conclusions,although bestavailable evidence supports the selective use of laparoscopy in this patient population. | Stavros A Antoniou George A Antoniou Oliver O Koch Rudolph Pointner Frank A Granderath | 2014 | World Journal of Gastroenterology2014，20，46： | 17 |
| 2 | 前列腺癌印记基因表达的特殊变化一前列腺癌发展和表观遗传调控的预示显示文摘DNA高甲基化和低甲基化,EZH2过度表达以及组蛋白修饰等表观遗传失调与前列腺癌的发展相关。DNA甲基化,EZH2和组蛋白修饰同时也确保了至少62种印记基因的亲缘特异性单等位基因的表达。尽管我们可以据此得到一个非常有趣的推断:表观遗传失调可能涉及到印记基因,但在前列腺癌中仅证明了IGF2的表达改变。一篇研究前列腺癌印记基因的文章和数据库显示,尽管表观遗传机制在全局上有干扰,但绝大多数印记基因表达没有变化。相反,选择性遗传和表观遗传的改变似乎抑制了印记基因亚网络,从而有可能在前列腺细胞中通过P13K/Akt途径限制细胞的生长,调节雄激素反应和调控分化。IGF2异常调控可能导致前列腺癌的早期改变,然而该印记基因网络的失活却与癌症的发展有关。 | Teodora Ribarska Klaus-Marius Bastian Annemarie Koch Wolfgang A Schulz | 2012 | Asian Journal of Andrology2012，14，3： | 4 |
| 3 | An investigation of functional and anatomical connectivity using magnetic resonance imaging显示文摘 | Koch M A Norris D G Hund-Georgiadis M | 2002 | NeuroImage2002，16，： | 2 |
| 4 | Laser in situ keratomileusis for myopia and astigmatism: safety and efficacy显示文摘 | Alan Sugar Christopher J Rapuano William W Culbertson David Huang Gary A Varley Peter J Agapitos Vincent P de Luise Douglas D Koch | 2002 | Ophthalmology2002，，1： | 2 |
| 5 | Characterisation of single stage,dual-pumped Raman fibre amplifiers for different gain fibre lengths 显示文摘 | KOCH F CHERNIKOV S V LEWIS S A E | 2000 | Electron Lett2000，36，4： | 2 |
| 6 | The Narcotrend monitor and the electroencephalogram in propofol-induced sedation显示文摘 | DOENICKE A W KUGLER J KOCHS E | 2007 | Anesth Analg2007，105，4： | 1 |
| 7 | Release of phosphorus from biological nutrient removal sludges: A study of sludge pretreatment methods to optimize phosphorus release for subsequent recovery purposes 显示文摘 | LIAO P H MAVINIC D S KOCH F A | 2003 | Journal of Environmental Science and Engineering2003，2，5： | 1 |
| 8 | TLR3 and TLR4 expression in healthy and diseased human endometrium显示文摘 | Allhorn S B(o)ing C Koch A A | 2008 | Reprod Biol Endocrinol2008，6，： | 1 |
| 9 | The transcription fac- tor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation 显示文摘 | Koch M A Tucker-Heard G Perdue N R | 2009 | Nat Immunol2009，10，6： | 1 |
| 10 | Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence 显示文摘 | Jahn B Koch A Schmidt A | 1997 | Infect Immun1997，65，12： | 1 |
| 11 | Isolation, characteriza- tion and cDNA cloning of nicotianamine synthase from barley, a key enzyme for iron homeostasis in plants显示文摘 | Herbik A Koch G Mock H P | 1999 | European Journal of Biochemistry1999，265，： | 1 |
| 12 | Lipid mediators in inflammatory disorders显示文摘 | Heller A Koch T Schmeck J | 1998 | Drugs1998，55，： | 1 |
| 13 | Hyperbaric oxygen induces apoptosis via a mitochondrial mechanism显示文摘 | Weber SU Koch A Kankeleit J | 2009 | Apoptosis2009，14，： | 1 |
| 14 | Bilateral facial palsy:EpsteinBarr virus,not Lyme disease显示文摘 | Diedler J Rieger S Koch A | 2006 | European Journal of Neurology2006，13，9： | 1 |
| 15 | , Ozonation of Hydrolyzed Azo Dye Reactive Yellow 84 (CI) 显示文摘 | Koch M Yediler A Lienert D | 2002 | Chemosphere2002，46，： | 1 |
| 16 | p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma显示文摘 | KOCH W M BRENNAN J A ZAHURAK M | 1996 | J Natl Can Inst1996，88，： | 1 |
| 17 | Tropical seagrass species tolerance to hyperssalinity stress 显示文摘 | Koch M S Schopmeyer S A Hansen C K | 2007 | Aquatic Botany2007，86，： | 1 |
| 18 | Angiogenesis and its targeting in rheumatoid arthritis显示文摘 | Szekanecz Z Koch A E | 2009 | Vascul Pharmacol2009，51，1： | 1 |
| 19 | Location of antigenic sites defined by neutralizing monoclonal antibodies on the S1 avian infectious bronchitis virus glycopolypeptide显示文摘 | Kant A Koch G van Roozelaar D J | 1992 | J Gen Virol1992，73，3： | 1 |
| 20 | Plasm a N-Teminal pro-B-type naturetic peptide for prediction of death or nonfatal myocardial infarction following percutancous coronary intervention显示文摘 | De winter RJ'strobants A Koch KT | 2004 | Am J Cantial2004，94，12： | 1 |
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