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| 1 | 主成分回归-极谱分析法测定吡嗪混合物显示文摘吡嗪及其甲基衍生物在弱酸性介质中具有良好的极谱波。但它们彼此重叠,无法作单一成分分析。本文在pH=4.8的McIlvane缓冲溶液中对吡嗪、2-甲基吡嚎、2,3-二甲基吡嗪和2,3,5-三甲基吡嗪多组分混合溶液在静汞电极上作微分脉冲极谱测定,所得的极谱重叠波数据用主成分回归法处理,获得了较好的定量分析结果。对于含量在0.15~1μg/ml之间的吡嗪及其甲基衍生物,回收率为95%~105%,相对标准偏差为4%~10%。 | 倪永年 Kokot S Selby M Hodgkinson M | 1993 | 分析化学1993，21，6： | 11 |
| 2 | 偏最小二乘法在多组分阳极溶出伏安分析中的应用——铜、锑、铋的同时测定显示文摘本文利用微分脉冲阳极溶出伏安法对微量铜、锑、铋混合溶液进行同时分析。实验在盐酸-氯化钠介质中进行,悬汞电极作工作电极,在-400mV处富集电解5min,然后由-400mV向0V作微分脉冲溶出伏安扫描,扫描速度为2mV/s,脉冲振幅为40mV。由计算机采集溶出伏安数据后采用偏最小二乘法计算并建立数学模型,然后据此模型对未知溶液进行定量分析,获得了较好的结果。 | 倪永年 KokotS SelbyM HodgkinsonM | 1994 | 分析化学1994，22，5： | 7 |
| 3 | Discrimination of Chinese traditional soy sauces based on their physico-chemical properties显示文摘This work aimed to classify the categories (produced by different processes) and brands (obtained from different geographical origins) of Chinese soy sauces.Nine variables of physico-chemical properties (density,pH,dry matter,ashes,electric conductivity,amino nitrogen,salt,viscosity and total acidity) of 53 soy sauce samples were measured.The measured data was submitted to such pattern recognition as cluster analysis (CA),principal component analysis (PCA),discrimination partial least squares (DPLS),linear discrimination analysis (LDA) and K-nearest neighbor (KNN) to evaluate the data patterns and the possibility of differentiating Chinese soy sauces between different categories and brands.Two clusters corresponding to the two categories were obtained,and each cluster was divided into three subsets corresponding to three brands by the CA method.The variables for LDA and KNN were selected by the Fisher F-ratio approach.The prediction ability of all classifiers was evaluated by cross-validation.For the three supervised discrimination analyses,LDA and KNN gave 100% predications according to the sample category and brand. | KOKOT Serge | 2010 | Science China Chemistry2010，53，6： | 6 |
| 4 | Authentication of Cassia seeds on the basis of two-wavelength HPLC fingerprinting with the use of chemometrics显示文摘High performance liquid chromatographic(HPLC) fingerprints of Cassia seed,a traditional Chinese medicine(TCM),were developed by means of the chromatograms at two wavelengths of 238 and 282 nm.Then,the two data sets were combined into one matrix.The application of principal component analysis(PCA) for this data matrix showed that the samples were clustered into four groups in accordance with the plant sources and preparation procedures.Furthermore,partial least squares(PLS),back propagation artificial neu... | Serge Kokot | 2010 | Chinese Chemical Letters2010，21，2： | 5 |
| 5 | Understanding nutrient build-up on urban road surfaces显示文摘This article discusses the outcomes of a research project on nutrients build-up on urban road surfaces.Nutrient build-up was investigated on road sites belonging to residential,industrial and commercial land use.Collected build-up samples were separated into five particle size ranges and were tested for total nitrogen (TN),total phosphorus (TP) and sub species of nutrients,namely,NO 2- ,NO 3- ,TKN and PO 43-.Multivariate analytical techniques were used to analyse the data and to develop detailed understanding on build- up.Data analysis revealed that the solids loads on urban road surfaces are highly influenced by factors such as land use,antecedent dry period and traffic volume.However,the nutrient build-up process was found to be independent of the type of land use.It was solely dependent on the particle size of solids build-up.Most of the nutrients were associated with the particle size range <150 μm.Therefore,the removal of particles below 150 μm from road surfaces is of importance for the removal of nitrogen and phosphorus from road surface solids build-up.It is also important to consider the difference in the composition of nitrogen and phosphorus build-up in the context of designing effective stormwater quality mitigation strategies. | Nandika Prasadani Miguntanna Ashantha Goonetilleke Prasanna Egodowatta Serge Kokot | 2010 | Journal of Environmental Sciences2010，22，6： | 5 |
| 6 | Investigation of the interaction of carbofuran and DNA by voltammetry and fluorescence with the aid of chemometrics显示文摘The interactions of carbofuran and DNA were studied using voltammetry and fluorescence spectroscopy.The formation of carbofuran-DNA makes the current peak of DNA decreased by voltammetry method.The binding number(n) and constant(K_a) for complex carbofuran-DNA were calculated to be 1.06±0.04 and 0.11±0.03mol^(-1) L,respectively by fluorescence measurement.Chemometrics approach,such as singular value decomposition(SVD) was used to evaluate the number of spectral species in the drug-DNA binding process.And the pure spectra and concentration profiles in the kinetic system were clearly deduced by multivariate curve resolution alternating least squares(MCR-ALS) with the initial estimates by evolving factor analysis(EFA). | Ying Xia Wang Yong Nian Ni Serge Kokot | 2010 | Chinese Chemical Letters2010，21，8： | 3 |
| 7 | Simultaneous Voltammetric Determination of Three Herbicides in Food and Water Samples with the Aid of Chemometrics显示文摘Differential pulse stripping voltammetry method(DPSV) was applied to the determination of three herbicides, ametryn, cyanatryn, and dimethametryn. It was found that their voltammograms overlapped strongly, and it is difficult to determine these compounds individually from their mixtures. With the aid of chemometrics, classical least squares(CLS), principal component regression(PCR) and partial least squares(PLS), voltammogram resolution and quantitative analysis of the synthetic mixtures of the three compounds were successfully performed. The proposed method was also applied to the analysis of some real samples with satisfactory results. | NI Yong-nian WANG Lin KOKOT Serge | 2009 | Chemical Research in Chinese Universities2009，25，2： | 3 |
| 8 | Investigation of the pharmacokinetics and determination of certain cephalosporins in rabbit plasma by a kinetic spectrophotometric method with the aid of chemometrics显示文摘This paper describes a kinetic spectrophotometric method for simultaneous determination of three cephalosporin antibiotics,cephradine,cefaclor and cefixime,with the aid of chemometrics. The method relies on their oxidation with KMnO4 to produce green manganate with different kinetic rates in alkaline medium. The proposed method was successfully applied to a pharmacokinetic study of three cephalosporin antibiotics in rabbit plasma via intravenous injections. The results indicated that the amount of cephradine,cefaclor and cefixime were reduced rapidly in rabbit blood,showing clear dose-dependency and the half-life of cefixime (160 min) was longer than those of cephradine (60 min) and cefaclor (60 min). | KOKOT Serge | 2011 | Science China Chemistry2011，54，5： | 3 |
| 9 | Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats显示文摘BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidly.Even with severe caval portal hypertension,BPC 157 antagonized portal and caval hypertension and aortal hypotension,and also reduced refractory ascites.Thrombosis of portal vein tributaries,inferior vena cava,and hepatic and coronary arteries was attenuated.In addition,there was reduced pathology of the lungs(severe capillary congestion)and liver(dilated central veins and terminal portal venules),decreased intestine hemorrhagic lesions(substantial capillary congestion,submucosal edema and architecture loss),and increased liver and spleen weight.During the period of ligation,nitric oxide-and malondialdehyde-levels in the liver remained within normal healthy values,and increases in serum enzymes were markedly reduced.CONCLUSION BPC 157 counteracts Budd Chiari syndrome in rats. | Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，1： | 2 |
| 10 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 11 | Simultaneous determination of three 5-nitroimidazoles in foodstuffs by differential pulse voltammetry and chemometrics显示文摘三 5-nitroimidazoles, metronidazole, tinidazole 和 ornidazole 的 voltammetric 行为,被调查,并且一个方法为这些混合物的同时的决心被开发,基于他们在在 8.95 与微分脉搏 voltammetric (DPV ) 缓冲的 pH 的一个挂的水银落下电极(HMDE ) 的减小来临。有 692, 640 和 652 mV 的山峰潜力的明确的 voltammetric 波浪分别地为这些混合物被观察。没有 preseparation,从他们的混合物个别地决定他们是困难的因为他们的 voltammetric 山峰严重重叠了,因此 chemometrics 被用来解决重叠 voltammogram 并且确定混合物。建议方法成功地在牛奶和蜂蜜样品被用于三 5-nitroimidazoles 的决心。 | Yi Gui Yong Nian Ni Serge Kokot | 2011 | Chinese Chemical Letters2011，22，5： | 2 |
| 12 | Voltammetric Determination of Chlorpromazine Hydrochloride and Promethazine Hydrochloride with the Use of Multivariate Calibration 显示文摘 | Ni Y N Wang L Kokot S | 2001 | Anal Chlm Acta2001，439，： | 2 |
| 13 | Application of differential pulse stripping voltammetry and chemometrics for the determination of three antibiotic drugs in food samples显示文摘为由在 BrittonRobinson 缓冲区剥去 voltammetry (DPSV ) 的微分脉搏的三抗菌素药(levofloxacin, gatifloxacin 和 lomefloxacin ) 的同时的决心的一个可靠方法(pH 7.96 ) 被介绍。方法在掉电极(HMDE ) 的挂的水银上基于抗菌剂药的吸附的累积,由 DPSV 的技术由吸附的种类的减小列在后面。最佳的条件, 80 s 的免职时间, 1250 mV 的免职潜力,和扫描 25 mV/s 评价,被获得。当察觉限制分别地是为 levofloxacin, gatifloxacin 和 lomefloxacin 的 2.38, 3.20 和 1.60 ng/mL 时, 0.0100.080 g/mL 的线性集中范围为所有这三抗菌素药被获得。在这个工作, chemometrics 方法例如古典最少的广场(CLS ) ,部分最少的广场(请) ,原则部件回归(PCR ) 和光线的基础功能人工的神经网络(RBF-ANN ) ,习惯于份量上解决重叠信号。PCR 与 7.71% 的全部的相对预言错误(RPET ) 给了最好的结果,这被发现。建议方法被使用与刺的方法在几件商业食物样品决定这三药并且产出令人满意的恢复。 | Yong Sheng Zhong Yong Nian Ni Serge Kokot | 2012 | Chinese Chemical Letters2012，23，3： | 2 |
| 14 | Specific metabolic biomarkers as risk and prognostic factors in colorectal cancer显示文摘Advances in genomics,molecular pathology and metabolism have generated many candidate biomarkers of colorectal cancer with potential clinical value.Epidemiological and biological studies suggest a role for adiposity,dyslipidaemia,hyperinsulinemia,altered glucose homeostasis,and elevated expression of insulin-like growth factor(IGF)axis members in the risk and prognosis of cancer.This review discusses some recent past and current approaches being taken by researches in obesity and metabolic disorders.The authors describe three main systems as the most studied metabolic candidates of carcinogenesis:dyslipidemias,adipokines and insulin/IGF axis.However,each of these components is unsuccessful in defining the diseases risk and progression,while their co-occurrence increases cancer incidence and mortality in both men and women. | Magorzata Muc-Wierzgoń Ewa Nowakowska-Zajdel Sylwia Dziegielewska-Gesiak Teresa Kokot Katarzyna Klakla Edyta Fatyga Elzbieta Grochowska-Niedworok Dariusz Waniczek Janusz Wierzgoń | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 15 | Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches 显示文摘 | Ni Y Wang S Kokot S | 2010 | Anal Chim Acta2010，663，2： | 1 |
| 16 | Simultaneous Kinetic Apectrophotometric Determination of Acetaminophen and Phenobarbital by Artificial Neural Networks and Partialleast Squares 显示文摘 | Ni Y N Liu C Kokot S | 2000 | Anal Chim Acta2000，419，12： | 1 |
| 17 | Interaction between quercetin - copper( Ⅱ ) complex and DNA with the use of the neutral red dye fluorophor probe显示文摘 | NI Yongnian DU Shan KOKOT S | 2007 | Anal Chim Acta2007，584，： | 1 |
| 18 | Simultaneous spectrophotometric determination of maltol,ethyl maltol,vanillin and ethyl vanillin in foods by multivariate calibration and artificial neural networks显示文摘 | Zhang G W Kokot S | 2005 | Food Chemistry2005，89，3： | 1 |
| 19 | The adipose tissue: a novel endocrine organ of interest to the nephrologist显示文摘 | WIECEK A KOKOT F CHUDEK J | 2002 | Nephrology Dialysis Transplantation2002，17，： | 1 |
| 20 | Synthesis and structure of synthetic zeolite ZSM-11显示文摘 | Kokotal G T | 1978 | Nature1978，275，5676： | 1 |
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