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| 1 | Fossil Association from the Lower Cambrian Yanjiahe Formation in the Yangtze Gorges Area,Hubei,South China显示文摘摘要:除了以前报导的小壳的石块(SSF ) ,一个宏观的石块集合,包括的丰富的水藻,锥形的管状的石块形式,和可能的印象一放大了后生动物,在西方的湖北省的 Yangtze 峡区域来自更低的寒武纪的 Yanjiahe 形成,华南。可见石块在 thinlaminated siltstone 被保存或泥泞 siltstone 在 815 公里厚的碳酸盐存款之间设置了,浅水里的抑制本地消沉的可能代表的沉积背景在早寒武纪的 Meishucunian 阶段期间焦化站台。宏观的石块协会关于生活的进化提供重要石块证据从对寒武纪的爆炸间隔晚前寒武纪。 | GUO Junfeng LI Yong HAN Jian ZHANG Xingliang ZHANG Zhifei OU Qiang LIU Jianni SHU Degan Shigenori MARUYAMA Tsuyoshi KOMIYA | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 8 |
| 2 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 3 | Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling显示文摘Photothermal 治疗(PTT ) 用在红外线附近(NIR ) 激光光和金 nanorods (GNR ) 作为一种新奇癌症治疗形式显示出诺言。然而,要求破坏肿瘤房间的激光紧张在皮肤下面定位了比阀值紧张大那原因皮肤损坏;因此,有激光光的照耀损坏皮肤以及肿瘤。这里,我们证明一个温度控制系统允许变形淋巴节点(行) 被 PTT 用 NIR 激光光和 GNR 对待,没有皮肤损坏。行转移的一个老鼠模型被肿瘤房间的注射开发,并且忍受肿瘤的合适的腋的行在 GNR 的注射以后与 NIR 激光光被对待。皮肤温度在 45 点被维持。潮湿转移能力索引(h D A/P ) 最大因为 30essure (BP ) ,心率(HR ) 和官方补给的症状在 270min 上被估计。 | Tessai Sugiura Daisuke Matsuki Junnosuke Okajima Atsuki Komiya Shiro Mori Shigenao Maruyama Tetsuya Kodama | 2015 | Nano Research2015，8，12： | 5 |
| 4 | The isolation and identification of apolipoprotein C-I in hormone-refractory prostate cancer using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry显示文摘雄激素在前列腺癌症致病起一个中央作用,并且因此病人的大多数对雄激素剥夺治疗作出回应。然而,病人们与好攻击的前列腺癌症趋于到恶化,它是被称为荷尔蒙倔强。识别调停的蛋白质前进到荷尔蒙倔强的状态,我们为病人的 sera 介绍的质量使用了蛋白质薄片技术。这研究与变形荷尔蒙倔强的前列腺癌症包括了 16 个病人开始与雄激素剥夺被对待治疗。浆液样品在五个次点从每个病人被收集:点 A,预告的处理;削尖 B,在前列腺特定的抗原(PSA ) 的天底水平;点 C, PSA 失败;点 D,早荷尔蒙倔强的阶段;并且削尖 E,晚荷尔蒙倔强的阶段。用提高表面的激光解吸附作用 / 电离 time-of-flight 团 spectrometry,我们执行了病人的 sera 介绍的蛋白质质量并且识别了与疾病前进增加了的 6 640-Da 山峰。目标蛋白质部分被净化,并且由氨基酸定序,山峰作为 apolipoprotein C-I 的碎片被识别(ApoC -- 我) 。浆液 ApoC -- 我蛋白质层次与疾病前进增加了。在 immunohistochemical 分析上, ApoC -- 我蛋白质被发现局部性到荷尔蒙倔强的癌症房间的细胞质。在这研究,我们在浆液 ApoC 显示出增加 -- 我蛋白质在他们的前进期间在前列腺癌症病人铺平到荷尔蒙倔强的状态,它建议那 ApoC -- 我蛋白质与前列腺癌症的前进有关。然而, ApoC 的准确角色 -- 我在前列腺癌症致病是不清楚的,进一步的研究被要求。 | Kaori Yamamoto-Ishikawa Hiroyoshi Suzuki Masahiko Nezu Naoto Kamiya Takashi Imamoto Akira Komiya Kazuyuki Sogawa Takeshi Tomonaga Fumlo Nomur Tomohiko Ichikawa | 2009 | Asian Journal of Andrology2009，11，3： | 3 |
| 5 | Internal Microanatomy and Zoological Affinity of the Early Cambrian Olivooides显示文摘The early Cambrian pentamerous microfossil Olivooides/Punctatus in South China,which is characterized by a diagnostic stellate tubular apex,has been well-known for its almost complete development sequence that can be confidently traced from embryos and hatched juveniles,to conical adults.However,its zoological affinity remains highly controversial.Here we describe the internal microanatomic structures of the soft-body inside the peridermal theca of Olivooides multisulcatus Qian,1977,including interradial pairs of tentacles,adradial and perradial frenula,perradial oral marginal lappets and twins of perradial gastric saccule-like humps as well as a circular velarium with striated coronal muscles.Particularly,one specimen shows bifurcated velarial canals along the bell aperture.Both the components of the soft-body and the external theca(or cyst)are arranged in perfect pentaradial symmetry.These characteristics are more compatible with those of living cubomedusans and co-occurring Cambrian athecate embryonic cubozoans.Concerning the presence of peridermal theca,Olivooides most likely represents an extinct thecate stem-group cubomedusae but devoid of both perradial eyes and specialized pedalia.The well-grown soft body inside the peridermal tube displays a set of mixed features of both polyp and medusa. | Han Jian LI Guoxiang KUBOTA Shin OU Qiang TOSHINO Sho WANG Xing YANG Xiaoguang UESUGI Kentaro MASATO Hoshino SASAKI Osamu KANO Harumasa SATO Tomohiko KOMIYA Tsuyoshi | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 3 |
| 6 | Effectiveness of therapeutic barium enema for diverticular hemorrhage显示文摘AIM:To evaluate the effectiveness of barium impaction therapy for patients with colonic diverticular bleeding.METHODS:We reviewed the clinical charts of patients in whom therapeutic barium enema was performed for the control of diverticular bleeding between August2010 and March 2012 at Yokohama Rosai Hospital.Twenty patients were included in the review,consisting of 14 men and 6 women.The median age of the patients was 73.5 years.The duration of the followup period ranged from 1 to 19 mo(median:9.8 mo).Among the 20 patients were 11 patients who required the procedure for re-bleeding during hospitalization,6patients who required it for re-bleeding that developed after the patient left the hospital,and 3 patients who required the procedure for the prevention of rebleeding.Barium(concentration:150 w%/v%)was administered per the rectum,and the leading edge of the contrast medium was followed up to the cecum by fluoroscopy.After confirmation that the ascending colon and cecum were filled with barium,the enema tube was withdrawn,and the patient’s position was changed every 20 min for 3 h.RESULTS:Twelve patients remained free of rebleeding during the follow-up period(range:1-19mo)after the therapeutic barium enema,including 9men and 3 women with a median age of 72.0 years.Re-bleeding occurred in 8 patients including 5 men and 3 women with a median age of 68.5 years:4developed early re-bleeding,defined as re-bleeding that occurs within one week after the procedure,and the remaining 4 developed late re-bleeding.The DFI(disease-free interval)decreased 0.4 for 12 mo.Only one patient developed a complication from therapeutic barium enema(colonic perforation).CONCLUSION:Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. | Mizue Matsuura Masahiko Inamori Atsushi Nakajima Yasuhiko Komiya Yumi Inoh Keigo Kawasima Mai Naitoh Yuji Fujita Akiko Eduka Noriyoshi Kanazawa Shiori Uchiyama Rie Tani Kennichi Kawana Setsuya Ohtani Hajime Nagase | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 7 | Influence of contamination on banded iron formations in the Isua supracrustal belt, West Greenland: Reevaluation of the Eoarchean seawater compositions显示文摘Banded Iron Formations(BIFs) are chemical sediments, ubiquitously distributed in the Precambrian supracrustal belts; thus their trace element compositions are helpful for deciphering geochemical evolution on the Earth through time. However, it is necessary to elucidate factors controlling the whole-rock compositions in order to decode the ancient seawater compositions because their compositions are highly variable. We analyzed major and trace element contents of the BIFs in the 3.8-3.7 Ga Isua supracrustal belt(ISB), southern West Greenland. The BIFs are petrographically classified into four types:Black-,Gray-, Green-and White-types, respectively. The Green-type BIFs contain more amphiboles, and are significantly enriched in Co, Ni, Cu, Zn, Y, heavy rare earth element(HREE) and U contents. However,their bulk compositions are not suitable for estimate of seawater composition because the enrichment was caused by secondary mobility of metamorphic Mg, Ca and Si-rich fluid, involvement of carbonate minerals and silicate minerals of olivine and pyroxene and/or later silicification or contamination of volcanic and clastic materials. The White-type BIFs are predominant in quartz, and have lower transition element and REE contents. The Gray-type BIFs contain both quartz and magnetite. The Black-type BIFs are dominated by magnetite, and contain moderate to high transition element and REE contents. But,positive correlations of V, Ni, Zn and U contents with Zr contents suggest that involvement of detrital,volcanic and exhalative materials influences on their contents. The evidence for significant influence of the materials on the transition element contents such as Ni in the BIFs indicates the transition element contents in the Archean ocean were much lower than previously estimated. We reconstructed secular variations of V,Co, Zn and U contents of BIFs through time, which show Ni and Co contents decreased whereas V, Zn and U contents increased through time. Especially, the Ni and Co contents drastically decreased in the Mesoarchean rather than around the Great Oxidation Event. On the other hand, the V,Zn and U contents progressively increased from the Mesoarchean to the Proterozoic. Stratigraphical trends of the BIFs show increase in Y/Ho ratios and decrease in positive Eu anomaly upwards, respectively. The stratigraphic changes indicate that a ratio of hydrothermal fluid to seawater component gradually decrease through the deposition, and support the Eoarchean plate tectonics, analogous to the their stratigraphic variations of seafloor metalliferous sediments at present and in the Mesoarchean. | Shogo Aoki Chiho Kabashima Yasuhiro Kato Takafumi Hirata Tsuyoshi Komiya | 2018 | Geoscience Frontiers2018，9，4： | 2 |
| 8 | Determination of ^88 Sr/^86 Sr mass-dependent isotopic and radiogenic isotope variation of ^87 Sr/^86 Sr in the Neoproterozoic Doushantuo Formation 显示文摘 | Ohno T Komiya T Ueno Y | 2008 | Gondwana Research2008，14，： | 1 |
| 9 | Development of a solitary bone cyst?a report of a case suggesting its pathogenesis显示文摘 | Komiya S Inoue A | 2000 | Arch Orthop Trauma Surg2000，120，： | 1 |
| 10 | Concerted expression of Eotaxin-1,Eotaxin-2,and Eotaxin-3 in human bronchial epithelial cells显示文摘 | Komiya A Nagase H Yamada H | 2003 | Cell Immunol2003，225，2： | 1 |
| 11 | The origin of extensive colour polymorphism in Plateumaris sericea ( Chrysomelidae, Coleoptera ) 显示文摘 | Kurachi M Takaku Y Komiya Y Hariyama T | 2002 | Naturwissenschaften2002，89，7： | 1 |
| 12 | Sesamin and episesamin induce apoptosis in human lymphoid leukemia Molt 4B cells显示文摘 | Miyahara Y Komiya T Katsuzaki H | 2000 | Internationl Journal of Molecular Medi- cine2000，6，1： | 1 |
| 13 | Laparoscopic adrenalectomy in patients with large adrenal tumors显示文摘 | Naya Y Suzuki H Komiya A | 2005 | Int J Urol2005，12，2： | 1 |
| 14 | Percutaneous drainage combined with hyperbaric oxygen therapy for pyogenic spondylitis with iliopsoas abscess显示文摘 | Tofuku K Koga H Komiya S | 2014 | Asian Spine J2014，8，： | 1 |
| 15 | Japanese encephalitis vires production in Vero cells with serum-free medium using a novel oscillating bioreactor 显示文摘 | TORINIWA H KOMIYA T | 2007 | Biologicals2007，35，： | 1 |
| 16 | Role of glutathione in cisplatin resistance in esteosactoma cell lines 显示文摘 | Komiya S Gebhardt MC Mangham DC | 1998 | Orthop Res1998，16，1： | 1 |
| 17 | Prognostic significance of telomeric repeat length alterations in pathological stage I-IIIa non-small cell lung cancer显示文摘 | Komiya T Nitta T | 2000 | Anticancer Res2000，20，： | 1 |
| 18 | Clinical features of cases of influenza A (H1N1)virus in Osaka prefecture,Japan,May 2009显示文摘 | Komiya N Gu Y Kamiya H | 2009 | Euro Surveill2009，14，19： | 1 |
| 19 | Coincidence theorems and saddle point theorem显示文摘 | Komiya H | 1986 | Proc Amer Math Soc1986，96，4： | 1 |
| 20 | Streptozocin and alloxaninduced H2O2 generation and DNA fragmentation in pancreatic islets显示文摘 | Takasu N Komiya I Asawa T | 1991 | Diabetes1991，40，9： | 1 |
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