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| 1 | Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression显示文摘Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy.In this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation. | Natsumi Kuwahara Riko Kitazawa Koto Fujiishi Yusa Nagai Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，8： | 11 |
| 2 | Electrochemical behavior of [UO_2Cl_4]^(2-) in 1-ethyl-3-methylimidazolium based ionic liquids显示文摘In order to examine the chemical form of uranyl species in 1-ethyl-3-methylimidazolium(EMI) based ionic liquids,UV-visible absorption spectra of solutions prepared by dissolving [EMI] 2 [UO2Cl4] into a mixture of EMICl and EMIBF 4(50:50 mol%) were measured.As a result,it was confirmed that uranyl species in the mixture of EMICl and EMIBF 4 existed as [UO2Cl4]2-.Cyclic voltammograms(CVs) of [UO2Cl4]2-in the mixture were measured at 25 ℃ using a Pt working electrode,a Pt wire counter electrode,and an Ag/Ag + reference electrode(0.01 M AgNO 3,0.1 M tetrabutylammonium perchlorate in acetonitrile) in a glove box under an Ar atmosphere.Peaks corresponding to one redox couple were observed around-1.05 V(Epc) and-0.92 V(Epa) vs.ferrocene/ferrocenium ion(Fc/Fc +).The potential differences between two peaks(Ep) increased from 101 to 152 mV with an increase in the scan rate from 50 to 300 mV s-1,while the(Epc+Epa)/2 value was constant,-0.989 V vs.Fc/Fc + regardless of the scan rate.Furthermore,the diffusion coefficient of [UO2Cl4]2-and the standard rate constant were estimated to be 3.7 × 10-8 cm 2 s-1 and(2.7-2.8) × 10-4 cm s-1 at 25 oC.By using the diffusion coefficient and the standard rate constant,the simulation of CVs was performed based on the reaction,[UO2Cl4]2-+ e = [UO2Cl4]3-.The simulated CVs were found to be consistent with the experimental ones.From these results,it is concluded that [UO2Cl4]2-in the mixture of EMICl and EMIBF 4 is reduced to [UO2Cl4]3-quasi-reversibly at-0.989 V vs.Fc/Fc +. | OGURA Toshinari SASAKI Kotoe TAKAO Koichiro ARAI Tsuyoshi IKEDA Yasuhisa | 2012 | Science China Chemistry2012，55，9： | 6 |
| 3 | Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus显示文摘AIM:To examine how the expression of caudal type homebox transcription factor 2(Cdx2) is regulated in the development of malignancy in Barrett's esophagus.METHODS:Cdx2,mucin(MUC) series(MUC2,MUC5AC and MUC6),p53 and E-cadherin expression in Barrett's esophagus and adenocarcinoma specimens were examined by immunostaining.Isolated clusters of cells from(1) MUC2 and Cdx2-positive intestinal metaplastic mucosa;(2) MUC5AC and MUC6-positive,and MUC2 and Cdx2-negative high-grade dysplasia(HD),or intramucosal adenocarcinoma(IMC);and(3) MUC5AC,MUC6 and Cdx2-positive poorly-differentiated invasive adenocarcinoma(PDA) were analyzed by methylationspecific polymerase chain reaction using sets of primers for detecting methylation status of the Cdx2 gene.RESULTS:Most of the non-neoplastic Barrett's esophageal mucosa showing intestinal-type metaplasia with or without low-grade dysplasia was positive for E-cadherin,MUC series and Cdx2,but negative for p53.A portion of the low-grade to HD was positive for E-cadherin,MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.The definite IMC area was strongly positive for MUC5AC,MUC6 and p53,but negative for MUC2 and Cdx2.Methylation of the Cdx2 promoter was not observed in intestinal metaplasia,while hypermethylation of part of its promoter was observed in hot dipped and IMC.Hypermethylation of a large fraction of the Cdx2 promoter was observed in PDA.CONCLUSION:Cdx2 expression is restored irrespective of the methylation status of its promoter.Apparent positive immunohistochemical results can be a molecular mark for gene silencing memory. | Kenji Makita Riko Kitazawa Shuho Semba Koto Fujiishi Miku Nakagawa Ryuma Haraguchi Sohei Kitazawa | 2013 | World Journal of Gastroenterology2013，19，4： | 5 |
| 4 | A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung 显示文摘 | Koto H Ichinose Y Ohta M | 2004 | N Engl J Med2004，350，17： | 1 |
| 5 | Characterization of nuclear factors for elicitor-mediated activation of the promoter of the Pea phenylalanine ammonia-lyase gene 1显示文摘 | Koto H Wada M Muraya K | 1995 | Plant Physiology1995，108，： | 1 |
| 6 | Repeated allergen exposure of semitized Brown-Norway rats induces airway cell DNA synthesis and remodelling 显示文摘 | Salmon M Walsh DA Koto H | 1999 | Eur Respir J1999，14，3： | 1 |
| 7 | Vision Loss by Central Reti- nal Vein Occlusion After Kaatsu Training: A Case Report 显示文摘 | Ozawa Y Koto T Shinoda H | 2015 | Medicine (Baltimore)2015，94，36： | 1 |
| 8 | Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases显示文摘 | Takano Y Koto Y Diest PJ | 2000 | Am J Pathol2000，156，2： | 1 |
| 9 | Nuclear and cytoplasmic LIMKI enhances human breast cancer progression 显示文摘 | Mcconnell BV Koto K Gutierrez-Hartmann A | 2011 | Mol Cancer2011，，10： | 1 |
| 10 | Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells显示文摘 | Takashi Koto Shoichiro Susumu Ishida | 2007 | Am J Pathology2007，170，4： | 1 |
| 11 | Evaluation of malignancy and the prognosis of esophageal cancer based on an immunohistochemical study (p53, E-cadherin, epidermal growth factor receptor) 显示文摘 | Inada S Koto T Futami K | 1999 | Surg Today1999，29，6： | 1 |
| 12 | 18F-fluorodeoxyglucose positron emission tomography immediately after chemoradiotherapy predicts prognosis in patients with locoregional postoperative recurrent esophageal cancer显示文摘 | Keiichi Jingu Tomohiro Kaneta Kenji Nemoto Ken Takeda Yoshihiro Ogawa Hisanori Ariga Masashi Koto Toru Sakayauchi Yoshihiro Takai Shoki Takahashi Shogo Yamada | 2010 | International Journal of Clinical Oncology2010，，2： | 1 |
| 13 | Solidification Cooling Rate and As-Cast Textures of Low-Carbon Steel Strips 显示文摘 | XU Ping-guang YIN Fu-xin NAGAI Koto | 2006 | Materials Science and Engineering A2006，441，12： | 1 |
| 14 | A stability property ofA-stable natural Runge-Kutta methods for systems of delay differential equations显示文摘 | T. Koto | 1994 | BIT1994，，2： | 1 |
| 15 | Stroke in systemic lupus erythematosis显示文摘 | Kitagawa Y Gooh F Koto A | 1998 | Stroke1998，21，12： | 1 |
| 16 | Distribution of gamma-aminobutyric acid and glutamate decarboxylase in the layers of rat oviduct 显示文摘 | Murashima Y L Koto T | 1986 | J Neurochem1986，46，： | 1 |
| 17 | Intravascular malignant lymphomatosis显示文摘 | M asaki TAKAO Atsuo KOTO | 1995 | Neurol Med (Japanese)1995，43，： | 1 |
| 18 | Stability and antiphase domain structure of the pyrochlore solid solution in the ZrO2-Gd2O3 system显示文摘 | UEHARA T KOTO K KANAMARU F | 1987 | Solid State Ionics1987，23，： | 1 |
| 19 | Pathology of lacunar infarction显示文摘 | Takao M Koto A | 2006 | Nippon Rinsho2006，64，8： | 1 |
| 20 | Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases显示文摘 | Raju U Ariga H Koto M | 2006 | Radiothe Oncol2006，80，2： | 1 |
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