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| 1 | Biomarkers in the clinical management of patients with atrial fibrillation and heart failure显示文摘Atrial fibrillation(AF)and heart failure(HF)are two cardiovascular diseases with an increasing prevalence worldwide.These conditions share common pathophysiologiesand frequently co-exit.In fact,the occurrence of either condition can‘cause’the development of the other,creating a new patient group that demands different management strategies to that if they occur in isolation.Regardless of the temproral association of the two conditions,their presence is linked with adverse cardi-ovascular outcomes,increased rate of hospitalizations,and increased economic burden on healthcare systems.The use of low-cost,easily accessible and applicable biomarkers may hasten the correct diagnosis and the effective treatment of AF and HF.Both AF and HF effect multiple physiological pathways and thus a great number of biomarkers can be measured that potentially give the clinician important diagnostic and prognostic information.These will then guide patient centred therapeutic management.The current biomarkers that offer potential for guiding therapy,focus on the physiological pathways of miRNA,myocardial stretch and injury,oxidative stress,inflammation,fibrosis,coagulation and renal impairment.Each of these has different utility in current clinincal practice. | Ioanna Koniari Eleni Artopoulou Dimitrios Velissaris Mark Ainslie Virginia Mplani Georgia Karavasili Nicholas Kounis Grigorios Tsigkas | 2021 | Journal of Geriatric Cardiology2021，18，11： | 8 |
| 2 | Kounis syndrome:a clinical entity penetrating from pediatrics to geriatrics显示文摘1 Introduction Kounis syndrome constitutes a coronary hypersensitivity disorder defined by the association of an anaphylactoid,anaphylactic,allergic or hypersensitivity reaction with an acute coronary syndrome,in a physiopathological context involving various interrelated and interacting inflammatory cells,such as mast-cells,eosinophils and platelets.[1,2]Similar entities to Kounis syndrome might involve cerebral and mesenteric arteries. | Mattia Giovannini Ioanna Koniari Francesca Mori Silvia Ricci Luciano De Simone Silvia Favilli Sandra Trapani Giuseppe Indolfi Nicholas George Kounis Elio Novembre | 2020 | Journal of Geriatric Cardiology2020，17，5： | 7 |
| 3 | After Administration of Intravenous Epinephrine for bee Sting-induced Anaphylaxis: Kounis Syndrome or Epinephrine Effect?显示文摘To the Editor: In the very important report published in Chinese Medical Journal,[1] a 50-year-old male patient, stented with a bare metal stent followed by 3 overlapping drug-eluting stents, developed anaphylactic reaction following a bee sting that was treated with intravenous 0.1 mg epinephrine at a 1:100,000 together with intravenous methylprednisolone, chlorpheniramine maleate, and ranitidine.He developed, immediately after, an anterior wall myocardial infarction, and subsequent coronary arteriography revealed total occlusion in the proximal left anterior descending stent and 90% stenosis with tissue growth in the mid-stent.The authors concluded that the acute myocardial infarction occurred due to acute stent thrombosis caused by exogenous epinephrine administration.This report, however, raises important questions related to the cause and pathophysiology of these events. | Nicholas G Kounis George D Soufras Dimitrios Lianas Nicholas Patsouras | 2016 | Chinese Medical Journal2016，，4： | 2 |
| 4 | Emergence, development, and future of cardio-oncology in China: cardiohypersensitivity, cardiotoxicity and the Kounis syndrome显示文摘To the Editor:Cancer and cardiovascular disease constitute the two major causes of death worldwide. Whereas the incidence of cancer increases among adults up to 74 years of age, above this age the cardiovascular disease surpasses cancer as the primary cause of mortality.[1] Currently, chemotherapy, radiation therapy, and surgery are the main modalities for the treatment of cancer. However, chemotherapy can induce cardiovascular worsening, manifesting as acute and chronic symptomatology. Therefore, the verv interesting report published in Chinese Medical Journal[2] concerning a 60-year-old male patient suffering from coronary artery disease and squamous cell carcinoma of the left lung who developed an ST segment elevation myocardial infarction following treatment with afatinib (tyrosine kinase inhibitor) and gemcitabine (antimetabolite pyrimidine antagonist) and cisplatin (platinum based DNA replication inhibitor) and the subsequent discussion raise several important considerations on cardiac toxicity, cardiac hypersensitivity and the Kounis-hypersensitivity acute coronary syndrome. | Nicholas G. Kounis Ioanna Koniari Panagiotis Plotas George D. Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 5 | Beta-blocker treatment in heart failure patients with atrial fibrillation:challenges and perspectives显示文摘Heart failure(HF)and atrial fibrillation(AF)are common conditions that share similar clinical phenotype and frequently coexist.The classification of HF in patients with preserved ejection fraction(>50%,HFpEF),midrange reduced EF(40%−49%,HFmrEF)and reduced EF(<40%,HFrEF)are crucial for optimising the therapeutic approach,as each subgroup responds differently.Betablocker constitute an important component of our pharmacological regimen for chronic HF.Betablocker administration is reccomended in patients with HF with reduced ejection fraction in stable sinus rhythm,due to improvement of symptoms,the better long termoutcome and survival.The beneficial role of betablocker use in patients with preserved EF still remain unclear,as no treatment showed a positive impact,regarding morbidity or mortality reduction.The presence of AF in HF patients increases as the disease severity evolves and is associated with a higher rate of cardiovascular morbidity and mortality.But more question is the use of betablocker in HF patients irrespective of EF and concomitant AF.There are many conflicting data and publications,regarding the beta blocker benefit in this population.Generally,it is supported an attenuation of betablockers beneficial effect in HF patients with AF.A design of more randomised trials/studies with HF patients and concomitant AF may improve our clinical approach of betablockers use and identify the patients with HF,who mostly profit from an invasive approach. | Emmanouil Chourdakis Ioanna Koniari Dimitrios Velissaris Grigorios Tsigkas Nikolaos G Kounis Neriman Osman | 2021 | Journal of Geriatric Cardiology2021，18，5： | 2 |
| 6 | Atrial fibrillation in patients with systolic heart failure:pathophysiology mechanisms and management显示文摘Heart failure(HF)and atrial fibrillation(AF)demonstrate a constantly increasing prevalence during the 21st century worldwide,as a result of the aging population and the successful interventions of the clinical practice in the deterioration of adverse cardiovascular outcomes.HF and AF share common risk factors and pathophysiological mechanisms,creating the base of a constant interrelation.AF impairs systolic and diastolic function,resulting in the increasing incidence of HF,whereas the structural and neurohormonal changes in HF with preserved or reduced ejection fraction increase the possibility of the AF development.The temporal relationship of the development of either condition affects the diagnostic algorithms,the prognosis and the ideal therapeutic strategy that leads to euvolaemia,management of noncardiovascular comorbidities,control of heart rate or restoration of sinus rate,ventricular synchronization,prevention of sudden death,stroke,embolism,or major bleeding and maintenance of a sustainable quality of life.The indicated treatment for the concomitant HF and AF includes rate or/and rhythm control as well as thromboembolism prophylaxis,while the progress in the understanding of their pathophysiological interdependence and the introduction of the genetic profiling,create new paths in the diagnosis,the prognosis and the prevention of these diseases. | Ioanna Koniari Eleni Artopoulou Dimitrios Velissaris Nicholas Kounis Grigorios Tsigkas | 2021 | Journal of Geriatric Cardiology2021，18，5： | 2 |
| 7 | Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome显示文摘 | Nicholas G Kounis Ioanna Koniari Emmanouil Chourdakis George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 8 | Early stent thrombosis secondary to food allergic reaction:Kounis syndrome following rice pudding ingestion显示文摘Kounis syndrome is the concurrence of coronary spasm, acute myocardial infarction or stent thrombosis, with allergic reactions in the setting of mast-cell and platelet activation. In this report Kounis syndrome manifesting as stent thrombosis with left ventricular thrombus formation was triggered by a food-induced allergic reaction. The allergic reaction to food was confirmed by oral rice pudding ingredients challenge test while skin tests were inconclusive. To our knowledge, this is first report of early stent thrombosis secondary to food allergic reaction in a 70-year-old man patient who was found to have left ventricular thrombus and undiagnosed hypertrophic cardiomyopathy. | Georgios Tzanis Maria Bonou Nikolaos Mikos Smaragda Biliou Ioanna Koniari Nicholas G Kounis John Barbetseas | 2017 | World Journal of Cardiology2017，9，3： | 2 |
| 9 | Cognitive function and oxidative stress after carotid endarterectomy: com- parison of propofol to sevoflurane anesthesia显示文摘 | Kalimeris K Kouni S Kostopanagiotou G | 2013 | J Cardiothorac Vasc Anesth2013，27，6： | 1 |
| 10 | Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus 显示文摘 | Kymionis GD Grentzelos MA Kounis GA | 2010 | J Cataract Refract Surg2010，36，10： | 1 |
| 11 | Eosinophilic responses to stent implantation and the risk of Kounis hypersensitivity associated coronary syndrome显示文摘 | Nicholas G. Kounis Sotiris Giannopoulos Grigorios G. Tsigkas John Goudevenos | 2011 | International Journal of Cardiology2011，，2： | 1 |
| 12 | Kounis syndrome: a monster for the atopic patient 显示文摘 | Kounis NG | 2013 | Cardiovase Diagn and Ther2013，3，1： | 1 |
| 13 | Trends in the design of nucleoside analogues as anti-HIV drugs显示文摘 | el Kouni M H | 2002 | Curr Pharm Des2002，8，8： | 1 |
| 14 | Simultaneous topography - guided photorefractive keratectomy followed by corneal collagen cross -linking for keratoconus 显示文摘 | KYMIONIS GD PORTALIOU DM KOUNIS GA | 2011 | Am J Ophthalmol2011，152，5： | 1 |
| 15 | Cognitive function and oxidative stress after carotid endarterectomy: com- parison of propofol to sevoflurane anesthesia 显示文摘 | Kalimeris K Kouni S Kostopanagiotou G | 2013 | J Cardiothorac Vase Anesth2013，27，6： | 1 |
| 16 | Adenosine metabolism in Toxoplasma gondii:potential targets for chemotherapy显示文摘 | El Kouni M H | 2007 | Curr Phar J-Teisai Des2007，13，6： | 1 |
| 17 | Adenosine metabolism in Toxoplasma gondii:poten tial targets for chemotherapy显示文摘 | EL Kouni MH | 2007 | CurrPharJ Teisai Des2007，13，6： | 1 |
| 18 | Comparison of Epi-LASIK and off-flap Epi-LASIK for the treatment of low and moderate myopia显示文摘 | Kalyvianaki MI Kymionis GD Kounis GA Panagopoulou SI Grentzelos MA Pallikaris IG | 2008 | Ophthalmology2008，115，12： | 1 |
| 19 | Trends in the design of nucleoside analogues as antiHIV drugs显示文摘 | KOUNI M H | 2002 | Curr Pharm Des2002，8，8： | 1 |
| 20 | Potential Chemotherapeutic Targets in the Purine Metabolism of Parasites显示文摘 | KOUNI M H | 2003 | Pharm Ther2003，99，： | 1 |
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