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| 1 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 2 | Specific enzyme complex of 13-1,4-galaetosyltransferase-II and glueuronyhransferase-P facili- tates biosynthesis of N-linked human natural killer-1 ( HNK-1 ) carbohydrate显示文摘 | Kouno T Kizuka Y Nakagawa N | 2011 | JBioChem2011，286，31： | 1 |
| 3 | Standardization of the body surface area (BSA) formula to calculate the dose of anticancer agents in Japan显示文摘 | Kouno T Katsumata N Mukai H | 2003 | Jpn J Clin Oncol2003，33，6： | 1 |
| 4 | Neolignans and a phenylpropanoid glucoside from Illicium difengpi显示文摘 | Isao Kouno Yang Chunshun Yukari Yanagida | 1993 | Phytochemistry1993，32，11： | 1 |
| 5 | Phe- nylpropanoids from the barks oflllicium difengpi 显示文摘 | Isao Kouno Chun - shu Yang Yukari Yanagida | 1992 | Chem Pharm Bull1992，40，9： | 1 |
| 6 | Slow-reacting and complement requiring neutralizing antibody in swine infected with porcine reproductive and respiratory syndrome (PRRS) virus显示文摘 | Jusa E R Inaba Y Kouno M | 1996 | J Vet Med Sci1996，58，： | 1 |
| 7 | Ne- olignans and a phenylpropanoid glucoside from Illicium difengpi 显示文摘 | Isao Kouno Chun - shun Yang Yukari Yanagida | 1993 | Phytochemistry1993，32，6： | 1 |
| 8 | A new triphenyl-type neolignan and a biphenylneolignan from the barks of Illicium simonsii显示文摘 | Isao Kouno Chifumi Iwamoto Yukl Kameda Takashi Tanaka Chun-shu Yang | 1994 | Chem Pharm Bull1994，42，1： | 1 |
| 9 | Importance of UDP-glucurono- syltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia 显示文摘 | Sumida K Kawana M Kouno E | 2013 | Mol Pharmacol2013，84，5： | 1 |
| 10 | Hepatoid adenocarcinoma of the gallbladder:case report and review of the literature显示文摘 | Sakamoto K Monobe Y Kouno M | 2004 | Pathol Intern2004，54，1： | 1 |
| 11 | Antimicrobial activity of 10different plant polyphenols against bacteria causing food-borne disease显示文摘 | TAGURI T TANAKA T KOUNO I | 2004 | Biol Pharm Bull2004，27，12： | 1 |
| 12 | Triterpenoids from Agrimonia pilosa显示文摘 | KOUNO L BABA N OHNI Y | 1988 | Phytochemistry1988，27，1： | 1 |
| 13 | The structure of moranoline,a piperidine alkaloid from Morus species显示文摘 | Yagi M Kouno T Aoyagi Y | 1976 | Nippon Nogei Kagaku Kaishi1976，50，11： | 1 |
| 14 | Two new Sesquineolignans from the bark of Illicium dunnianum显示文摘 | Isao Kouno Takuya Morisaki Yumiko Hara Chun-shu Yang | 1991 | Chem Pharm Bull1991，39，10： | 1 |
| 15 | Comparison of neonatal outcome including cerebral palsy between abruptio placentae and placenta previa 显示文摘 | Matsuda Y Maeda T Kouno S | 2003 | Enr J Obstet Gynecol Reprod Biol2003，106，2： | 1 |
| 16 | A novel black tea pigment and two new oxidation products of epigallocatechin-3-o-gallate显示文摘 | Takashi Tanaka Yosuke Matsuo Isao Kouno | 2005 | Journal of Agricultural and Food Chemistry2005，53，75： | 1 |
| 17 | Two diastereomeric-ligan esters having dimeric structure and their biosynthetically related triperpene caffeate from Rhoiptelea chiliantha显示文摘 | Jiang Z H Tanaka T Kouno I | 1994 | Tetrahedron Lett1994，35，： | 1 |
| 18 | Fetal/neonatal outcome in abruptio placentae during pretenn gestation 显示文摘 | Matsuda Y Maeda T Kouno S | 2005 | Semin Thromb Hemost2005，31，3： | 1 |
| 19 | A lupane triperpene and two triperpene caffeated from Rhoiptelea chiliantha显示文摘 | Jiang Z H Tanaka T Kouno I | 1994 | Phytochemistry1994，40，： | 1 |
| 20 | Current trends an controversies over pre-operative chemotherapy for women with operable breast cancer 显示文摘 | Shimizu C Ando M Kouno T | 2007 | Jpn J Clin Oncol2007，37，1： | 1 |
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