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| 1 | 中国系统性金融压力的监测显示文摘及时有效地识别和监测金融风险,判断风险的演化方向,对于宏观审慎措施和危机干预措施的制定有重要意义。然而,许多常用的风险度量指标仅适用于单个市场,难以反映系统性风险。由于系统性金融风险爆发时期的一个重要特征是各金融市场风险联动性、传染性的显著增强,本文基于这个特征,构建了描述中国金融市场系统性压力的指数——中国CISS。本文选取债券市场、金融部门、股票市场和外汇市场的13个子指标,用子指标间时变的相关系数矩阵作为动态权重,对市场间相关性增强且各子指标均上升到高位的情况(显示风险在市场之间的传染)赋予更高的权重,以此识别系统性压力。结果显示,中国CISS指标的峰值与历史上的金融风险事件高度吻合,且具备很好的稳健性,可以及时发挥监测金融市场压力的作用。 | 清华大学国家金融研究院金融与发展研究中心课题组 马骏 Manfred Kremer 何晓贝 刘姝睿 王立升 | 2019 | 国际金融研究2019，0，12： | 28 |
| 2 | 降酸方法对葡萄酒降酸效果的影响显示文摘本文研究了葡萄酒酿造过程中,不同的降低酸的方法对葡萄酒降酸效果的影响。本试验采用化学降酸法,即向葡萄汁之中加入化学试剂K2CO3,KHCO3和CaCO3以达到降低酸度的目的;生物降酸法,即在葡萄汁之中加入苹果酸-乳酸发酵和物理降酸法,即低温冷冻降酸法。结果表明,K2CO3的降酸效果最好,其次是低温冷冻降酸法。降酸效果最差的是采用苹果酸-乳酸发酵菌所进行的降酸方法。 | 陈继峰 Bill Kremer | 2001 | 中外葡萄与葡萄酒2001，，3： | 20 |
| 3 | Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases显示文摘AIM To establish a relevant animal model ofhuman gastrointestinal cancer, which can beused for repetitive investigations, so as toimprove our understanding and management ofcarcinogenesis and cancer metastasis.METHODS Intact tissues of human colorectaland pancreatic cancers were transplanted innude mice. The biological characteristics of theoriginal and the corresponding transplantedtumors were investigated by HE staining, PASstaining and immunostaining. The metastases inthe livers and lungs of nude mice wereinvestigated by immunostaining withbiotinylated mab KL-1 and by RT-PCR using CK20specific primers.RESULTS There were totally 9 of 16 surgicalspecimens growing in nude mice subcutaneouslyand/.or orthotopically (4 of 6 colorectal and 5 of10 pancreatic cancer). Tumor cell content of thespecimens and freezing of tissue specimens areimportant factors influencing the growth oftransplanted tumor. In the group of fresh tumortissues with greater than 50% tumor cellcontent, the success rate of the transplantationwas 100% (3 cases of pancreatic cancer and 3cases of colorectal cancer). The orthotopicallytransplanted tumors resemble the original tumormorphologically and biologically, including TAAexpression such as CEA byimmunohistochemistry, and CEA level in theserum of mice. Ki-67 labeling index and theexpression of TAA especially K-ras, 17-lA andRA-96, are associated with the potential of tumorgrowth in nude mice. Micrometastases in thelungs and livers of tumor bearing mice can bedetected by immunostaining with biotinylatedmab KL-1 and CK20-specific RT-PCR.CONCLUSION An orthotopic transplantationmodel for human colon and pancreatic cancer innude mice has been set up. We have alsoestablished sensitive detection methods withCK-immunohistochemistry and CK20-RT-PCR tostudy xenotransplanted human cancer and itsmetastatic cancer cells in the liver and lung ofnude mice. This study may be helpful inunderstanding the mechanism of cancermetastasis and in developing new diagnosticmethods and therapeutic strategies formetastases including micrometastases. | Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 4 | Vitamin D deficiency/insufficiency from childhood to adulthood:Insights from a sunny country显示文摘Vitamin D is known to be a key regulator of bone metabolism and is associated with muscle strength.Vitamin D deficiency is widely prevalent worldwide.In adults,vitamin D deficiency has been implicated in numerous health conditions including osteoporosis,cancer,diabetes,and autoimmune diseases.Considerable changes have occurred in lifestyles and childhood activities in the past years.Studies have shown that the children population is at high risks of vitamin D deficiency.The objective of this study was to learn about the extent of vitamin D deficiency in children worldwide and especially in sunny country like Israel.In this article we reviewed the extent and severity of vitamin D deficiency worldwide and especially in Israel,through a very comprehensive review of previous reports and research studies done during the last years.We found reports on vitamin D deficiency in children,which was associated with metabolic syndromes and obesity.It was more prevalent in children who spend less time on outdoor activities,in obese children,and in cases when there was imbalance between nutritional intakes and requirements.Vitamin D deficiency is common even in children living in sunny places like Israel.Health professionals should be aware of the fact that although vitamin D deficiency is prevalent in the elderly population,it is also common in children,and can be associated with different illnesses.We encourage supplementation of vitamin D to special populations(pregnant and lactating women,infants,and high risk groups).We also encourage implementation of international food fortification programs. | Motti Haimi Richard Kremer | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 17 |
| 5 | 用于电容传感器信号转换的集成电路CAV424显示文摘文中介绍了测量电容式传感器电容的一般方法 ,并针对AMG公司开发的电容式信号转换成电压信号的集成电路CAV4 2 4作了应用性介绍。 | Torg Stecker Helmut Kremer | 2003 | 仪表技术与传感器2003，，1： | 13 |
| 6 | A model to predict survival in patients with end-stage liver disease显示文摘 | Patrick S. Kamath Russell H. Wiesner Michael Malinchoc Walter Kremers Terry M. Therneau Catherine L. Kosberg Gennaro D’Amico E.Rolland Dickson W.Ray Kim | 2001 | Hepatology2001，，2： | 10 |
| 7 | Advances in hepatitis C therapy: What is the current state-what come's next?显示文摘Chronic hepatitis C virus(HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease.It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin.However,treatment of HCV has undergone a revolutionary change in recent years.The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents(DAA).Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure.High rates of sustained virological response(SVR) rates can be achieved with these novel drugs.Even in difficult to treat populations such as patients with liver cirrhosis,HCV-human immunodeficiency virus co-infections,after liver transplantion,or with chronic kidney disease comparable high rates of SVR can be achieved.The anticipated 2nd generation DAAs are strikingly effective in patients so far classified as difficult to treat including decompensated liver cirrhosis or posttransplant patients.These 2nd generations DAAs will have higher resistance barriers,higher antiviral effects and a pan-genotypic spectrum.This review highlights the current state of the art of antiviral treatment in hepatitis Cand gives an outlook for upcoming therapies. | Steffen Zopf Andreas E Kremer Markus F Neurath Juergen Siebler | 2016 | World Journal of Hepatology2016，8，3： | 7 |
| 8 | IS6110限制性片段多态性分析标准方法的建立及其在结核分枝杆菌分子分型中的应用显示文摘目的建立IS6110限制性片段多态性分析(IS6110一RFLP)标准方法并评价该方法的分型能力。方法采用核酸提取、PCR、限制性内切酶分析、Southern杂交、琼脂糖凝胶电泳等技术,结合Gel—Proanalyzer3.1和BioNumerics(Version5.0)软件,对78株结核分枝杆菌插入序列IS6110-RFLP进行分析。结果确定标准化的IS6110-RFLP技术,包括核酸提取、PCR、限制性内切酶分析、Southern杂交、琼脂糖凝胶电泳等实验步骤及标化参数的相关数据分析软件的使用;采用该技术,将78株结核分枝杆菌分为75个不同的基因型,分别归属于11个基因簇,其中有52株归属于同一个基因簇,占菌株总数的66.7%(52/78)。结论建立标准化的IS6110-RFLP技术方案,该方法具有很强的基因分型和株水平鉴定能力,可用于结核病的病原学监测。 | 刘敬华 Kristin Kremer Christine Pourcel Arnout Mulder 刘志广 赵秀芹 万康林 | 2008 | 中华流行病学杂志2008，29，8： | 5 |
| 9 | Efficacy and Safety of Tofacitinib in Chinese Patients with Rheumatoid Arthritis显示文摘Background:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA).This study assessed the efficacy and safety of tofacitinib in Chinese patients with RA enrolled in Phase 3and long-term extension (LTE)studies. Methods:ORAL Sync was a 1-year,randomized,placebo-controlled,Phase 3trial.Patients received tofacitinib 5 or 10 mg twice daily (BID)or placebo advanced to tofacitinib 5 or 10 mg BID at 3 or 6 months.All patients remained on >1background conventional synthetic disease-modifying antirheumatic drug.ORAL Sequel is an open-label LTE study (data-cut:March 2015;data collection and analyses were ongoing,and study database was not locked at the time of analysis;study was closed in 2017).Efficacy outcomes:American College of Rheumatology (ACR)20/50/70response rates and Disease Activity Score in 28 joints using erythrocyte sedimentation rate (DAS28-4[ESR]).Patient-and physician-reported outcomes:HealthAssessment Questionnaire-Disability Index (HAQ-DI),Patient and Physician Global Assessment of Arthritis,and pain (visual analog scale).Safety was assessed throughout. Results:ORAL Sync included 218 patients;192 were subsequently enrolled into ORAL Sequel.In ORAL Sync,more patients achieved ACR20(tofacitinib 5 mg BID,67.4%;10 mg BID,70.6%;placebo,34.1%)and DAS28-4(ESR)<2.6(tofacitinib 5 mg BID,7.1%; 10mg BID,13.1%;placebo,2,3%)with tofacitinib versus placebo at Month 6.Mean changes from baseline in HAQ-DI were greater with tofacitinib versus placebo at Month 6.In ORAL Sequel,efficacy was consistent to Month 48.Incidence rates for adverse events of special interest in tofacitinib-treated patients were similar to the global population. Conclusions:To.facitinib significantly reduced signs/symptoms and improved physical function and quality of life in Chinese patients with moderate-to-severely active RA up to Month 48.The safety profile was consistent with the global population. | Zhan-Guo Li Yi Liu Hu-Ji Xu Zhi-Wei Chen Chun-De Bao Jie-Ruo Gu Dong-Bao Zhao Yuan An Lie-Ju Hwang Lisy Wang Joel Kremer Qi-Zhe Wu | 2018 | Chinese Medical Journal2018，，22： | 5 |
| 10 | 核磁共振对高分子材料结构的在线分析显示文摘传统NMR技术需将被检测物体置于高频超导磁铁中心,其应用范围受到了很大限制。近年来出现了一种新型便携式核磁共振通用表面探测仪(NMR-MOUSE),它可以放置于被检测物表面进行在线分析,灵敏地检测出材料的变化,可在相关领域用于评估材料性能,并预测材料的使用寿命。文中主要介绍NMR-MOUSE的基本原理,并着重讨论其在非均相橡胶和塑料高分子聚合物表征领域中的应用情况。 | 任晓红 王靖岱 阳永荣 Kai Kremer Bernhard Bliimich | 2008 | 高分子材料科学与工程2008，24，1： | 4 |
| 11 | Antioxidant and antimicrobial properties of Moltkia petraea (Tratt.) Griseb. flower, leaf and stem infusions显示文摘 | M. Zovko Kon?i? D. Kremer J. Gruz M. Strnad G. Bi?evac I. Kosalec D. ?amec J. Piljac-?egarac K. Karlovi? | 2010 | Food and Chemical Toxicology2010，，6： | 4 |
| 12 | Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization显示文摘AIM: To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs.METHODS: We used two strategies (SSH suppression subtractive hybridization and hybridization of cDNA arrays)to determine early changes in gene expression profiles in a rat model of partial WI/R, comparing postischemic and adjacent nonischemic liver lobes. Differential gene expression was verified (WT/R; 1 h/2 h) and analyzed in more detail after warm ischemia (1 h) in a reperfusion time kinetics (0, 1, 2 and 6 h) and compared to untreated livers by Northern blot hybridizations. Protein expression was examined on Western blots and by immunohistochemistry for four differentially expressed target genes (Hsp70,Hsp27, Gadd45a and IL-1rl).RESULTS: Thirty-two individual WI/R target genes showing altered RNA levels after confirmation by Northern blot analyzes were identified. Among them, six functionally uncharacteristic expressed sequences and 26 known genes (12 induced in postischemic liver lobes, 14 with higher transcriptional expression in adjacent nonischemic liver lobes). Functional categories of the verified marker genes indicate on the one hand cellular stress and tissue damage but otherwise activation of protective cellular reactions (AP-1 transcription factors, apoptosis related genes, heat shock genes). In order to assign the transcriptional status to the biological relevant protein level we demonstrated that Hsp70, Hsp27, Gadd45a and IL-1rI were clearly up-regulated comparing postischemic and untreated rat livers, suggesting their involvement in the WI/R context.CONCLUSION: This study unveils a WI/R response gene set that will help to explore molecular pathways involved in the tissue damage after WI/R. In addition, these genes especially Hsp70and Gadd45a might represent promising new candidates indicating WI/R liver damage. | Christine Fallsehr Christina Zapletal Michael Kremer Resit Demir Magnus von Knebel Doeberitz Ernst Klar | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 13 | Evidence-Based Incorporation of Serum Sodium Concentration Into MELD显示文摘 | Scott W. Biggins W. Ray Kim Norah A. Terrault Sammy Saab Vijay Balan Thomas Schiano Joanne Benson Terry Therneau Walter Kremers Russell Wiesner Patrick Kamath Goran Klintmalm | 2006 | Gastroenterology2006，，6： | 3 |
| 14 | Natural killer T cells and non-alcoholic fatty liver disease:Fat chews on the immune system显示文摘Natural killer T cells (NKT) are an important subset of T lymphocytes. They are unique in their ability to produce both T helper 1 and T helper 2 associated cytokines, thus being capable of steering the immune system into either inflammation or tolerance. Disruption of NKT cell numbers or function results in severe deficits in immune surveillance against pathogens and tumor cells. Growing experimental evidence suggests that hepatosteatosis may reduce resident hepatic as well as peripheral NKT cells. Those models of hepatosteatosis and the change in NKT cell numbers are associated with a disruption of cytokine homeostasis, resulting in a more pronounced release of proinflammatory cytokines which renders the steatotic liver highly susceptible to secondary insults. In this letter to the editor, we focus on recently published data in the World Journal of Gastroenterology by Xu and colleagues demonstrating reduced peripheral NKT cells in patients with non-alcoholic fatty liver disease, compare those findings with ours and others in different animal models of hepatosteatosis, and hypothesize about the potential underlying mechanism. | Michael Kremer Ian N Hines | 2008 | World Journal of Gastroenterology2008，14，3： | 3 |
| 15 | α-氨基酸在葡萄酒发酵中的变化显示文摘研究分析了葡萄酒原料之中的α 氨基酸的含量 ,以及添加酵母营养粉之后对α 氨基酸含量的影响 ;继而分析了新酒之中α 氨基酸的含量。α 氨基酸在发酵过程中的消耗 ,表明了酵母菌对α 氨基酸的利用情况。所以 ,为保证酒精发酵的顺利进行 ,在酒精发酵之前 ,往葡萄汁之中添加酵母营养物质是必不可少的。 | 陈继峰 Bill Kremer 胡小松 李绍华 | 2001 | 酿酒2001，28，1： | 3 |
| 16 | 增糖方法对灰比诺葡萄酒质量的影响显示文摘对4种调整糖度方法对葡萄酒质量的影响进行了比较,采用的葡萄品种为灰比诺,可溶性固形物为19.5oBrix,通过不同的调整糖度措施使可溶性固形物提高2.5oBrix,达到22oBrix。4种调整糖度方法分别为:直接往葡萄汁中加入蔗糖;往葡萄汁中加入68oBrix浓缩葡萄汁;冷冻除冰使葡萄汁浓缩和借助反渗透机器浓缩葡萄汁。结果表明,在调整糖度幅度为2.5oBrix的情况下,不同调整糖度方法对葡萄酒的质量影响不大。 | 陈继峰 Bill Kremer | 2007 | 酿酒科技2007，，6： | 3 |
| 17 | Model for end-stage liver disease (MELD) and allocation of donor livers显示文摘 | Russell Wiesner Erick Edwards Richard Freeman Ann Harper Ray Kim Patrick Kamath Walter Kremers John Lake Todd Howard Robert M. Merion Robert A. Wolfe Ruud Krom | 2003 | Gastroenterology2003，，1： | 2 |
| 18 | 光学相干断层成像技术诊断深Ⅱ度烧伤创面实验研究显示文摘目的 评估光学相干断层成像技术(OCT)在诊断烧伤创面深度方面的应用价值.方法 应用自制的小鼠蒸气烫伤装置,制作Skh-1小鼠深Ⅱ度烫伤模型,分别于伤后3 h、3 d和8 d以OCT扫描创面行动态检测,同步采集创面组织行组织病理学检查;同时扫描小鼠正常部位皮肤并行组织病理学检查. 结果蒸气烫伤小鼠皮肤真皮胶原降解,与其正常部位皮肤相比,在OCT扫描检测中表现为双折射光信号的丢失或减弱,其变化强度与创面病变过程相关,且与组织病理学切片结果一致. 结论 OCT作为无创的创面检测技术,可用于烧伤创面动态检测. | 刘淑华 谢卫国 Mathias Kremer Hans Guenther Machens Eva Maria Lankenau Gereon Huettmann | 2010 | 中华烧伤杂志2010，26，4： | 2 |
| 19 | A model to predict survival in patients with end-stage liver disease显示文摘 | Patrick S. Kamath Russell H. Wiesner Michael Malinchoc Walter Kremers Terry M. Therneau Catherine L. Kosberg Gennaro D'Amico E.Rolland Dickson W.Ray Kim | 2001 | Hepatology2001，，2： | 2 |
| 20 | Simultaneous wavefront-guided photorefractive keratectomy and corneal collagen crosslinking after intrastromal corneal ring segment implantation for keratoconus显示文摘 | Israel Kremer Isaac Aizenman Henia Lichter Sagit Shayer Samuel Levinger | 2012 | Journal of Cataract & Refractive Surgery2012，，10： | 2 |
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