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| 1 | Dopamine: an immune transmitter显示文摘The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies. | Sarah Thomas Broome Krystal Louangaphay Kevin AKeay Gian Marco Leggio Giuseppe Musumeci Alessandro Castorina | 2020 | Neural Regeneration Research2020，15，12： | 5 |
| 2 | Dual potential of microalgae as a sustainable biofuel feedstock and animal feed显示文摘The rise in global population has led to explorations of alternative sources of energy and food. Because corn and soybean are staple food crops for humans, their common use as the main source of dietary energy and protein for food-producing animals directly competes with their allocation for human consumption. Alternatively, de-fatted marine microalgal biomass generated from the potential biofuel production may be a viable replacement of corn and soybean meal due to their high levels of protein, relatively well-balanced amino acid profiles, and rich contents of minerals and vitamins, along with unique bioactive compounds. Although the full-fatted(intact) microalgae represent the main source of omega-3(n-3) polyunsaturated fatty acids including docohexaenoic acid(DHA)and eicosapentaenoic acid(EPA), the de-fatted microalgal biomass may still contain good amounts of these components for enriching DHA/EPA in eggs, meats, and milk. This review is written to highlight the necessity and potential of using the de-fatted microalgal biomass as a new generation of animal feed in helping address the global energy, food, and environmental issues. Nutritional feasibility and limitation of the biomass as the new feed ingredient for simple-stomached species are elaborated. Potential applications of the biomass for generating value-added animal products are also explored. | Krystal K Lum Jonggun Kim Xin Gen Lei | 2014 | Journal of Animal Science and Biotechnology2014，5，1： | 2 |
| 3 | Update of endoscopy in liver disease:More than just treating varices显示文摘The management of complications in liver disease is often complex and challenging.Endoscopy has undergone a period of rapid expansion with numerous novel and specialized endoscopic modalities that are of increasing value in the investigation and management of the patient with liver disease.In this review,relevant literature search and expert opinions have been used to provide a brief overview and update of the current endoscopic management of patients with liver disease and portal hypertension.The main areas covered are safety of endoscopy in patients with liver disease,the use of standard endoscopy for the treatment of varices and the role of new endoscopic modalities such as endoscopic ultrasound,esophageal capsule,argon plasma coagulation,spyglass and endomicroscopy in the investigation and treatment of liver-related gastrointestinal and biliary pathology.It is clear that the role of the endoscopy in liver disease is well beyond that of just treating varices.As the technology in endoscopy expands,so does the role of the endoscopist in liver disease. | Christoforos Krystallis Gail S Masterton Peter C Hayes John N Plevris | 2012 | World Journal of Gastroenterology2012，18，5： | 2 |
| 4 | Contrasting treatment and outcomes of septic shock: presentation on hospital floors versus emergency department显示文摘背景病人与腐败吃惊有高死亡。这研究使用了幸存败血运动( SSC )比较特征的数据库,治疗和结果腐败在紧急情况部门(编辑)诊断到病人发展的吃惊病人腐败在医院地板( HF )上震惊学习人口包括了的 .Methods 病人们在18月的经期上承认了一个城市的第三级的照顾医学中心的特别护理单位( ICU )。尖锐生理学和长期的健康评估( APACHE )得分,对机械通风( MV )的需要,四 SSC 复活捆指示物上的性能,停留( LOS )的 ICU 长度,医院 LOS 和在里面医院死亡是 ascertained.Results 66 个版本和 27 HF 腐败吃惊病人在这研究被包括。尿道感染(UTI ) 和肺病是在 ED 病人的感染的二个很普通的地点。为 HF 的感染的来源腐败吃惊病人很好相当越过病原学被散布。完成优异静脉 cava 氧浸透(ScvO2 ) 的时间 70% 在 HF 病人((10.8 ? | WANG Zhen Chrism Schorr Krystal Hunter R. Phillip Dellinger | 2010 | Chinese Medical Journal2010，，24： | 2 |
| 5 | The changing perspective on chronic insomnia management 显示文摘 | Krystal AD | 2004 | J Clinic Psychiatry2004，65，8： | 1 |
| 6 | Amplification,expression and packageing of a foreign gene by influenza virus 显示文摘 | Luytjes W Krystal M Enami M | 1989 | Cell1989，59，： | 1 |
| 7 | The selective tyrosine kinase inbibitor STI671 inhibits small cell lung cancer growth显示文摘 | Krystal GW Honsawek S Litz J | 2000 | Clin Cancer Res2000，6，8： | 1 |
| 8 | Impairment of GABAergie transmission in depression; new insights from neuroimag-ing studies显示文摘 | Sanacora G Mason GF Krystal JH | 2000 | Crit Rev Neurobiol2000，14，1： | 1 |
| 9 | Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized,6-week sleep laboratory trial显示文摘 | Ivgy-May N Ruwe F Krystal A | 2015 | Sleep Med2015，16，7： | 1 |
| 10 | Sleep qualityvaries as a function of 5-HTTLPR genntype and stress显示文摘 | Brmnmett BH Krystal AD Ashley-Koch A | 2007 | Psychosom Med2007，69，7： | 1 |
| 11 | Chro- moendoscopy in small bowel capsule endoscopy: Blue mode or fuji intelligent colour enhancement显示文摘 | KRYSTALLIS C KOULAOUZIDIS A DOUGLAS S | 2011 | Dig Liver Dis2011，43，9： | 1 |
| 12 | Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological and biochemical correlates 显示文摘 | Rasmussen K Beitner-Johnson D Krystal J H | 1990 | J Neurosci1990，10，7： | 1 |
| 13 | Glutamate-mod- ulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder显示文摘 | PITFENGER C KRYSTAL J H CORIC V | 2006 | Am Soc Exp Neuro Rx2006，3，1： | 1 |
| 14 | Effects of antipsychotic medications on sleep in schizophrenia 显示文摘 | Krystal AD Goforth HW Roth T | 2008 | Int Clin Psychopharmacol2008，23，： | 1 |
| 15 | Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor显示文摘 | Krystal GW Hines SJ Organ CP | 1996 | Cancer Res1996，56，2： | 1 |
| 16 | The implementation and use of e - learning in the corporate u-niersity 显示文摘 | ALI EN MACPHERSON GILL HOMAN KRYSTAL WILKIN- SON | 2005 | The Journal of Workplace Leam(ng2005，17，12： | 1 |
| 17 | The selective tyrosine kinase inhibitor STI-571 inhibits small cell lung cancer growth显示文摘 | Krystal G W Honsawek S Litz J | 2000 | Clin Cancer Res2000，6，8： | 1 |
| 18 | Two nuclear location signals in the influenza virus NS1 nonstructural protein显示文摘 | Greenspan D Palese P Krystal M | 1988 | Virol1988，62，8： | 1 |
| 19 | Efficacy and safety of doxepin 1 mg and 3 mg in a 12-week sleep laboratory and outpatient trial of elderly subjects with chronic primary insomnia 显示文摘 | Krystal AD Durrence HH Scharf M | 2010 | Sleep2010，33，11： | 1 |
| 20 | The selective tyrosine kinase inhibitor ST1571 inhibits small cell lung cancer growth 显示文摘 | Krystal GW Honsawek S Litz J | 2000 | Clin Cancer Res2000，6，8： | 1 |
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