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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | Effect of Multiple Coatings of One-step Self-etching Adhesive on Microtensile Bond Strength to Primary Dentin显示文摘Objective To investigate the effect of multiple coatings of the one-step self-etching adhesive on immediate microtensile bond strength to primary dentin.Methods Twelve caries-free human primary molars were randomly divided into 2 groups with 6 teeth each.In group 1,each tooth was hemisected into two halves.One half was assigned to control subgroup 1,which was bonded with a single-step self-etching adhesive according to the manufacturer's instructions;the other half was assigned to experimental subgroup 1 in which the adhesive was applied three times before light curing.In group 2,the teeth were also hemisected into two halves.One half was assigned to control subgroup 2,which was bonded with the single-step self-etching adhesive according to the manufacturer's instructions;the other half was assigned to experimental subgroup 2 in which three layers of adhesive were applied with light curing each successive layer.Microtensile bond strength was immediately tested after specimen preparation.Results When the adhesive was applied three times before light curing,the bond strength of the experimental subgroup 1(n=33,57.49±11.61 MPa) was higher than that of the control subgroup 1(n=31,49.71±11.43 MPa,P<0.05).When using the technique of applying multiple layers of adhesive with light curing each successive layer,no difference of immediate bond strength was observed between the control subgroup 2 and the experimental subgroup 2(P>0.05).Conclusion Multiple coatings of one-step self-etching adhesive can increase the immediate bond strength to primary dentin when using the technique of light-curing after applying three layers of adhesive. | Lin Ma Jian-feng Zhou Jian-guo Tan Quan Jing Ji-zhi Zhao Kuo Wan | 2011 | Chinese Medical Sciences Journal2011，26，3： | 4 |
| 3 | A new classification of nevus of Ota显示文摘 | Huang Wen-hui Wang Hong-wei Sun Qiu-ning Jin Hong-zhong Liu Yue-hua Ma Dong-lai Zuo Ya-gang Zheng He-yi Wan Kuo Jing Quan Zhao Yong-liang | 2013 | Chinese Medical Journal2013，，20： | 3 |
| 4 | Effectiveness and Safety of Computer-controlled Periodontal Ligament Injection System in Endodontic Access to the Mandibular Posterior Teeth显示文摘Objective To evaluate the effectiveness and safety of a computer-controlled periodontal ligament(PDL) injection system to the local soft tissues as the primary technique in endodontic access to mandibular posterior teeth in patients with irreversible pulpitis.Methods A total of 162 Chinese patients who had been diagnosed with irreversible pulpitis in their mandibular posterior teeth without acute infection or inflammation in the periodontal tissues were enrolled in this clinical study.The patients were divided into 3 groups according to the position of the involved tooth:the premolar group(PM,n=38),first molar group(FM,n=66),and second molar group(SM,n=58).All the patients received computer-controlled PDL injection with 4% articaine and 1∶100 000 epinephrine.Immediately after the injection,endodontic access was performed,and the degree of pain during the treatment was evaluated by the patients using Visual Analogue Scale for pain.The success rates were compared among the 3 groups.The responses of local soft tissues were evaluated 3-8 days and 3 weeks after the procedure.Results The overall success rate was 76.5%.There was a significant difference in success rates among the PM,FM,and SM groups(92.1%,53.0%,93.1%,respectively;χ2=34.3,P<0.01).Both the PM and SM groups showed higher success rates than that of the FM group(v=1,χ2=16.73,P<0.01;v=1,χ2=24.5,P<0.01).No irreversible adverse effects on the periodontal soft tissues at the injection sites were observed in the follow-up visits in any of the groups.Conclusion The computer-controlled PDL injection system demonstrates both satisfactory anesthetic effects and safety in local soft tissues as primary anesthetic technique in endodontic access to the mandibular posterior teeth in patients with irreversible pulpitis. | Quan Jing Kuo Wan Xiao-jun Wang Lin Ma | 2014 | Chinese Medical Sciences Journal2014，29，1： | 3 |
| 5 | Medical Emergencies in Dental Clinics: A Survey of 2013 Dentists in China显示文摘Objective To investigate the feature and frequency of medical emergencies in dental clinics in China and the Methods A survey study was conducted among 2408 dentists who attended continuing educational courses held by Society of Sedation and Analgesia of Chinese Stomatological Association in 18 cities from December 2015 to December 2018.Demographic information of the dentists and the characteristics of medical emergencies they encountered were collected and analyzed.The associated demographic features for dentist experiencing medical emergencies were analyzed by logistic regression model.Results A total of 2013 dentists provided valid responses and reported 2923 events of medical emergencies in dental clinics.Among them,85.0%reported that they had encountered medical emergencies,and 35.5%had encountered at least twice.Syncope(35.9%)and hypoglycemia(30.3%)were the most common reported medical emergencies.Medical emergencies were most likely to occur during local anesthesia(49.9%),out-patient oral surgery(25.9%),and root canal treatment(11.3%).There were 6 patients(0.2%)died in emergencies.84.0%dentists reported that they had never received training courses about medical emergency management in dentistry other than Basic Life Support.Longer practicing time(10-15 years)(OR=0.59,95%CI:0.41-0.85,P=0.004),working in private dental facilities(OR=1.69,95%CI:1.20-2.38,P=0.003)were associated with an increased risk of experiencing medical emergencies.Conclusion More efforts are needed in prevention,early identification,and timely management of medical emergencies in dental clinics in order to prevent fatal outcomes.The results of this survey are useful information for re-designing emergency training courses for Chinese dentists. | Quan Jing Kuo Wan Lin Ma Jizhi Zhao | 2020 | Chinese Medical Sciences Journal2020，35，4： | 2 |
| 6 | Influence of order degree of coaly graphite on its structure change during preparation of graphene oxide显示文摘Coaly graphite is an important natural graphite resource that derived from coal under a natural process that associated with igneous intrusion.Flake graphite is usually used for the chemical synthesis of graphene oxide(GO),the main precursor for preparation of graphene,but few papers pay attention to preparing GO using coaly graphite.In this paper,four kinds of natural coaly graphite with different graphitization degrees were exposed to a modified Hummer’s oxidation method to prepare GO.The flake graphite sample was also used for comparison.The results showed that the structural change process from graphite to GO were significantly affected by the graphitization degree of the original coaly graphite.The relationship between yields of GO and graphitization degrees of the coaly graphite was explored.The mechanism of why the graphite with low graphitization degrees cannot be totally oxidized was proposed.Coaly graphite with a graphitization degree of higher than 80% was easier to be oxidized and yielded the same amount of GO as the flake graphite did,suggesting it is the potential substitute for the flake graphite to produce GO in bulk quantities. | Dandan Hou Kuo Li Rujia Ma Qinfu Liu | 2020 | Journal of Materiomics2020，6，3： | 2 |
| 7 | Tidal Asymmetry Changes in a Shallow Mud Estuary by a Restoration Project显示文摘The tidal asymmetry-induced siltation below tidal barriers is a worldwide problem that restricts regional socio-economic and environmental development. The hydrodynamic processes of the small mud estuary also feature a high uncertainty after estuary restoration measures. In this study, a hydrodynamic model based on the MIKE21 is used to quantify the responses of tidal asymmetry to a two-phase restoration project in Shuanglong Estuary, Bohai Bay, China. According to the numerical modeling results, the tidal flat removal in the upper estuary(first-phase restoration) induces the flood asymmetry switching to the ebb asymmetry in unrestored reach but enhances flood asymmetry in widening restored reach. Although the tidal asymmetry reverts to flood-dominated pattern after full restoration over the estuary, the imbalance between flood and ebb velocities is relieved. A possible net sediment transport pattern based on a comparison of dominant asymmetric current and actual sediment transport period shows net sediments in the upper estuary and inlet transport seaward and landward, respectively, in the first-phase restoration, whereas landward net sediment transport occurs in the whole estuary under the second-phase restoration scenario. Given these results, we assume that a switch from the flood-dominated estuary to ebb-dominated estuary can be caused by redesigning the cross-sectional profile. The quantitative comparison of Lagrangian residual currents also implies that a channel–shoal structure rather than a flat bathymetry can promote the mass transport. Therefore, reshaping the channel–tidal flat system in restoration projects can prevent the sedimentation of the estuary and improve the water environment. | LIANG Huidi KUANG Cuiping GU Jie MA Yue CHEN Kuo LIU Xu | 2019 | Journal of Ocean University of China2019，18，2： | 2 |
| 8 | Chemokine gene polymorphisms in idiopathic anterior uveitis显示文摘 | Yeo TK Ahad MA Kuo NW | 2006 | Cytokine2006，35，12： | 1 |
| 9 | Identification ar molecular markers in soybean comparing RFLP, RAPD and AFLP DNA mapping techniques显示文摘 | Lin J J Kuo J Ma J | 1996 | Plant Molecular Biology Reporter1996，14，2： | 1 |
| 10 | Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer:the PACIFIC study显示文摘 | Austin MA Kuo E Van Den Eeden SK | 2013 | Cancer Epidemiol Biomarkers Prev2013，22，10： | 1 |
| 11 | Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane显示文摘 | Yao J-Y Kuo M-T | 2007 | Invest Ophthalmol Vis Sci2007，48，： | 1 |
| 12 | Posttraumatic symptoms were worst among quake victims with injuries following the Chi-chi quake in Taiwan显示文摘 | Kuo H W Wu S J Ma T C | 2007 | Journal of Psychosomatic Research2007，62，4： | 1 |
| 13 | Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study 显示文摘 | Austin MA Kuo E Van Den Eeden SK | 2013 | Cancer Epidemiol Biomarkers Prev2013，22，10： | 1 |
| 14 | A comparative study on egg hatching methods and oncosphere viability determination for Taenia solium eggs 显示文摘 | Wang IC Ma YX Kuo CH etal | 1997 | Int J Parasitol1997，27，11： | 1 |
| 15 | A PCR - based DNA fingerpriming technique: AFLP for molecular typing of bacteria 显示文摘 | LIN J J KUO J MA J | 1996 | Nucleic Acids Res1996，24，18： | 1 |
| 16 | Posttraumatic symptoms were worst among quake victims with injuries following the Chi-chi quake in Taiwan显示文摘 | Kuo H W Wu S J Ma T C | 2007 | J Psychosom Res2007，62，4： | 1 |
| 17 | Posttraumatic symptoms were worst among quake victims with injuries following the Chi - chi quake in Taiwan 显示文摘 | Kuo HW Wu SJ Ma TC | 2007 | Psychosom Res2007，62，4： | 1 |
| 18 | A comparative study on egg hatching methods and oncosphere viability determination for Taenia solium eggs显示文摘 | Wang I C Ma Y X Kuo C H | 1997 | Int J Parasitol1997，27，11： | 1 |
| 19 | Symptom distresses and coping strategies in pa- tients with non- small cell lung eancer显示文摘 | Kuo TT Ma FC | 2002 | Lung Cancer2002，25，4： | 1 |
| 20 | A RCR-based DNA fingerprinting technique:AFLP for molecular typing of bacteria显示文摘 | Lin JJ Kuo J Ma J | 1996 | Nucleic AcidsResearch1996，24，： | 1 |
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