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| 1 | Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells显示文摘AIM: To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1 β and interferon-γ-mediated β cell death and abolition of insulin secretion. METHODS: By employing BRIN-BD11 cells, the effects of SA-Et administration on cytokine-mediated cell death and abolition of insulin secretion were evaluated by a viability assay, cell cycle analysis, and insulin assay. The associated gene and protein expressions were also measured. In addition, the bioactivities of several peak compounds collected from the SA-Et were tested against cytokine-mediated β cell death.RESULTS: Our Results revealed that SA-Et dose-dependently ameliorated cytokine-mediated β cell death and apoptosis. Instead of suppressing inducible nitric oxide synthase/nitric oxide cascade or p38MAPK activity, suppression of stress-activated protein kinase/c-Jun NH2-terminal kinase activity appeared to be the target for SA-Et against the cytokine mix. In addition, SA-Et provided some insulinotropic effects which re-activated the abolished insulin exocytosis in cytokine-treated BRIN-BD11 cells. Finally, schiarisanrin A and B isolated from the SA-Et showed a dose-dependent protective effect against cytokine-mediated β cell death. CONCLUSION: This is the first report on SA-Et ameliorating cytokine-mediated β cell death and dysfunction via anti-apoptotic and insulinotropic actions. | Yi-Shin Hsu Yao-Haur Kuo Hui-Ling Cheng Peter R Flatt Hui-Kang Liu | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 2 | Acoustic measurements of models of military style supersonic nozzle jets显示文摘Modern military aircraft jet engines are designed with variable-geometry nozzles to provide optimal thrust in different operating conditions,depending on the flight envelope. However,acoustic measurements for such nozzles are scarce,due to the cost involved in making fullscale measurements and the lack of details about the exact geometries of these nozzles. Thus the present effort at Pennsylvania State University(PSU) in partnership with GE Aviation and the NASA Glenn Research Center is aiming to study and characterize the acoustic field produced by supersonic jets issuing from converging-diverging military style nozzles,and to identify and test promising noise reduction techniques. An equally important objective is to develop methodology for using data obtained from small- and moderate-scale experiments to reliably predict the full-scale engine noise. The experimental results presented show reasonable agreement between small-scale and medium-scale jets,as well as between heated jets and heat-simulated ones. | Ching-Wen Kuo Jérémy Veltin Dennis K.McLaughlin | 2014 | Chinese Journal of Aeronautics2014，27，1： | 2 |
| 3 | Synthesis and macroscopic secondorder nonlinear optical properties of poly (ether imide)s containing a novel two-dimensional carbazole chromophore with nitro acceptors显示文摘 | Kuo W J Hsiue G H Jeng R J | 2002 | J Mater Chem2002，12，： | 2 |
| 4 | 显示文摘 | Smith R | 1998 | Transactions of International Chemical Engineering(Part A)1998，76，： | 1 |
| 5 | High color rendering white light-emitting-diode illuminator using the red-emitting Eu^2+ -activated CaZnOS phosphors excited by blue LED 显示文摘 | Kuo T W Liu W R Chen T M | 2010 | Optics Express2010，18，8： | 1 |
| 6 | Fuzzy neural networks with application to sales for casting显示文摘 | Kuo R J Xue K C | 1999 | Fuzzy Sets and Systems1999，108，： | 1 |
| 7 | An assessment of testing-effort dependent software reliability growth models 显示文摘 | HUANG C Y KUO S Y LYU M R | 2007 | IEEE Trans on Reliability2007，56，2： | 1 |
| 8 | Evaluation of fusaric acid as a factor in development of Fusarium wilt显示文摘 | Kuo M S Seheffer R P | 1964 | Phytopathology1964，54，： | 1 |
| 9 | An application of particle swarm optimization algorithm to clustering analy- sis显示文摘 | KUO R J WANG M J HUANG T W | 2011 | Soft Computing2011，15，3： | 1 |
| 10 | Karyotype analysis of some Formosan gymnosperms显示文摘 | Kuo S R | 1972 | Taiwania1972，17，1： | 1 |
| 11 | A unified scheme of some nonhomogenous poisson process models for software reliability estimation显示文摘 | HUANG C v LYU M R KUO S | 2003 | IEEE Transactions on Software Engineering2003，29，3： | 1 |
| 12 | MDA5plays a crucial role in enterovirus 71RNA-mediated IRF3 activation显示文摘 | Kuo R L Kao L T Lin S J Wang R Y Shih S R | 2013 | PLoS One2013，8，63： | 1 |
| 13 | Assimilation of GPS ra- dio occultation data for numerical weather prediction 显示文摘 | Kuo Y H Sokolovskiy S V Anthes R A | 2000 | Terrestrial Atmospheric and Oceanic Sciences2000，11，1： | 1 |
| 14 | Health-related quality of life for nasopharyngeal carcin-oma patients with cancer-free survival after treatment 显示文摘 | Fang F M Chiu H C Kuo W R | 2002 | Int J Radiat Oncol Biol Phys2002，53，4： | 1 |
| 15 | Comparing gel permeation chromatography and ultrafiltration for the molecular weight characterization of aquatic organic matter显示文摘 | Collins M R Kuo C J | 1987 | J AWWA1987，79，1： | 1 |
| 16 | Association rule mining through the ant colony system for national health insurance research database in Taiwan显示文摘 | KUO R J SHIH CW | 2007 | Computers and Mathematics with Applications2007，54，： | 1 |
| 17 | Origins of the residual stress in CVD diamond films显示文摘 | Kuo C T Lin C R Lien H M | 1996 | Thin Solid Films1996，，： | 1 |
| 18 | High-efficiency poly(phenylenevinylene)-co-fluorene copolymers incorporating a triphenylamine as the end group for white-light-emitting diode applications显示文摘 | Kuo C H Cheng W K Lin K R | 2007 | Journal of Polymer Science (Part A) : Polymer Chemistry2007，45，19： | 1 |
| 19 | Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria 显示文摘 | Yoshida M Kobayashi K Kuo T T Bry L Glickman J N Claypool S M Kaser A Nagaishi T Higgins D E Mizoguchi E Wakatsuki Y Roopenian D C Mizoguchi A Lencer W I and Blumberg R S | 2006 | The Journal of Clinical Investigation2006，116，： | 1 |
| 20 | Development and characterization of high performance solid propellants containing nano-sized energetic ingredients显示文摘 | Luman J R Wehrman B Kuo K K | 2007 | Proceed- ings of the Combustion Institute2007，31，： | 1 |
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