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| 1 | 肥大细胞源性组织蛋白酶G在狭窄主动脉瓣不良改变中的可能作用显示文摘Aims: Aortic stenosis(AS) is characterized by extensive remodelling of the valves, including infiltration of inflammatory cells, extracellular matrix degradation, and fibrosis. The molecular mechanisms behind this adverse remodelling have remained obscure. In this article, we study whether cathepsin G, an angiotensin Ⅱ(Ang Ⅱ)forming elastolytic enzyme, contributes to progression of AS. Methods and results: Stenotic aortic valves(n=86) and control valves(n=17) were analysed for cathepsin G, transforming growth factor-β1(TGF-β1), and collagens I and Ⅲ with RT-PCR and immunohistochemistry. Valvular collagen/elastin ratio was quantified by histochemistry. In stenotic valves, cathepsin G was present in mast cells and showed increased expression(P< 0.001), which correlated positively(P< 0.001)with the expression levels of TGF-β1 and collagens I and Ⅲ. TGF-β1 was also present in mast cell rich areas and cathepsin G induced losartan-sensitive TGF-β1 expression in cultured fibroblasts. Collagen/elastin ratio was increased in stenotic valves(P< 0.001) and correlated positively with smoking(P=0.02). Nicotine in cigarette smoke activated mast cells and induced TGF-β1 expression in cultured fibroblasts. Fragmented elastin was observed in stenotic valves containing activated cathepsin G-secreting mast cells and in normal valves treated with cathepsin G. Conclusion: In stenotic aortic valves, mast cell-derived cathepsin G may cause adverse valve remodelling and AS progression. | Helske S. Syvranta S. Kupari M. K.A. Lindstedt 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 7 |
| 2 | Is the pregnancy hor- mone relaxin an important player in human heart failure?显示文摘 | Kupari M Mikkola TS Turto H | 2005 | Eur J Heart Fail2005，7，2： | 1 |
| 3 | Aldosteron synthase ( CYP11 B2 ) polymorphisms and cardiovascular function 显示文摘 | White PC Hautanen A Kupari M | 1999 | Mol Biol1999，69，： | 1 |
| 4 | Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size mass and function显示文摘 | Kupari M Hautanen A Lankinen L | 1998 | Circulation1998，97，： | 1 |
| 5 | Association between human aldosterone synthase gene polymorphisms and left ventricular size, mass, and function 显示文摘 | Kupari M Hantanen A Lankinen L | 1998 | Circulation1998，97，6： | 1 |
| 6 | Acute alcohol intake decreases short-term heart rate variability in healthy subjects显示文摘 | Koskinen P Virolainen J Kupari M | 1994 | Clin Sci(Lond)1994，87，2： | 1 |
| 7 | Double-peaking circadian variation in the occurrence of sustained supraventricular tachyarrhythmias显示文摘 | Kupari M Koskinen P Leinonen H | 1990 | Am Heart J1990，120，61： | 1 |
| 8 | Associations between aldosteronesynthasegene polymnrphismand theadrencortieal function inmales 显示文摘 | Hautanena A Kupari M Gankimen L | 1998 | J Intern Med1998，244，1： | 1 |
| 9 | Association between human aldosterone synthase gene polymorphisms and left ventricular size,mass,and function显示文摘 | Kupari M Hautanen A Lankinen L | 1998 | Circulation1998，97，6： | 1 |
| 10 | Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample 显示文摘 | Lindroos M Kupari M Heikkila J | 1993 | J Am Coll Cardiol1993，21，： | 1 |
| 11 | Prevalence of aortic valve abnormalities in the elderly: an echocardiographie study of a random population sample显示文摘 | Lindroos M Kupari M Heikkila J | 1993 | J Am Coil Cardiol1993，21，5： | 1 |
| 12 | Right and left atrial phasic volumetric function in mildly symptomatic dilated and hypertrophic cardiomyopath y: cine MR imaging assessment显示文摘 | Jarvenen VM Kupari MM Poutanen VP | 1996 | Radiology1996，198，2： | 1 |
| 13 | Prevalence of aortic valveabnormalities in the elderly : an echocardiographic study of a random population sample 显示文摘 | Lindroos M Kupari M Heikkila J | 1993 | J Am Coll Cardiol1993，21，5： | 1 |
| 14 | Ultrasonograph in the quantification of arterial involvement in Takaysu'arteritis显示文摘 | Ranine RO Kupari MM Pamilo MS | 2000 | Scand J Rheumatol2000，29，2： | 1 |
| 15 | Associations between human aldosterone synthase (CYP11B2 ) gene polymorphisms and left ventricular size, mass, and function显示文摘 | Kupari M Hautanen A Lankinen L | 1998 | Circulation1998，97，： | 1 |
| 16 | Combined blowing with three-hole lance in a sidewall blowing converter显示文摘 | Kupari P A Juntunen V A | 2001 | Steel Research2001，72，7： | 1 |
| 17 | Associations between aldosterone synthase gene polymorphism and the adrencortical function in males显示文摘 | Hautanena A Kupari M Gankimen L | 1998 | J Intern Med1998，244，1： | 1 |
| 18 | Prevalence of aortic valve abnormalities in the elderly:an echocardiographic study of a random population sample显示文摘 | Lindroos M Kupari M Heikkila J | 1993 | J Am Coll Cardiol1993，21，7： | 1 |
| 19 | Associations between aldosterone synthase gene polymorphism and the adrenocortical function in male显示文摘 | HAUTANENA A LANLINEN L KUPARI M | 1998 | J Intern Med1998，244，7： | 1 |
| 20 | Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males显示文摘 | Hautanena A Kupari M Lankimen L | 1998 | J Intern Med1998，244，： | 1 |
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