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| 1 | Perspectives of pluripotent stem cells in livestock显示文摘The recent progress in derivation of pluripotent stem cells(PSCs)from farm animals opens new approaches not only for reproduction,genetic engineering,treatment and conservation of these species,but also for screening novel drugs for their efficacy and toxicity,and modelling of human diseases.Initial attempts to derive PSCs from the inner cell mass of blastocyst stages in farm animals were largely unsuccessful as either the cells survived for only a few passages,or lost their cellular potency;indicating that the protocols which allowed the derivation of murine or human embryonic stem(ES)cells were not sufficient to support the maintenance of ES cells from farm animals.This scenario changed by the innovation of induced pluripotency and by the development of the 3 inhibitor culture conditions to support naïve pluripotency in ES cells from livestock species.However,the long-term culture of livestock PSCs while maintaining the full pluripotency is still challenging,and requires further refinements.Here,we review the current achievements in the derivation of PSCs from farm animals,and discuss the potential application areas. | Dharmendra Kumar Thirumala R Talluri Naresh L Selokar Iqbal Hyder Wilfried A Ku | 2021 | World Journal of Stem Cells2021，13，1： | 4 |
| 2 | Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps显示文摘AIM:To determine,by counting micronucleus (MN) frequencies,whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC,24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34,3.58 ± 1.21 vs 1.97 ± 0.81,P < 0.001). However,there was no difference in the MN frequency between CRC patients and NP patients (P > 0.05). Similarly,there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P > 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC. | Ali Karaman Dogan Nas■r Binici Mehmet E■ref Kabalar Züleyha ■al■ku■u | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Digital inkjet printing for chitosan-treated cotton fabric显示文摘 | P S R Choi C W M Yuen S K A Ku | 2005 | Fibers and Polymers2005，6，3： | 1 |
| 4 | Structural stifness and coulomb damping in compliant foil journal bearings: theoretical considerations 显示文摘 | Ku C-P R Heshmat H | 1994 | STLE Tri Trans1994，37，3： | 1 |
| 5 | Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment显示文摘 | Krewski D Withey J R Ku Lung-fa | 1994 | Environmental Health Perspectives1994，102，11： | 1 |
| 6 | Evidence for the function of the free radical gas - nitric oxide (NO) - as an endogenous maturation and senescence regulating factor in higher plants 显示文摘 | Leshem Y Y Wills R B H Ku V V V | 1998 | Plant Physiol Biochem1998，36，： | 1 |
| 7 | Leiomyomatosis peri- tonealis disseminata with malignant ehange in a post-meno- pausal woman显示文摘 | Sharma P Chaturvedi KU Gnpta R | 2004 | Gyneeol Oneol2004，95，3： | 1 |
| 8 | Structural damping of selfacting compliant foil journal bearings 显示文摘 | Heshmat H Ku C-P R | 1994 | ASME Jour of Trib Trans1994，116，1： | 1 |
| 9 | Association of low leptin with cardiovascular events and mortlity inpatients with stable coronary artery disease : the Heart and Soul Study 显示文摘 | Ku lA Farzaneh-Far R Vittinghoff E | 2011 | Atherosclerosis2011，217，2： | 1 |
| 10 | Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy 显示文摘 | Kayali R Ku JM Khitrov G | 2012 | Hum Mol Genet2012，21，18： | 1 |
| 11 | Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice显示文摘 | Ku N O Michie S A Soetikno R M | 1998 | J Cell Biol1998，143，： | 1 |
| 12 | Evidence for the function of the free radical gas-nitric oxide (NO)-as an endogenous maturation and senescence regulating factor in higher plants显示文摘 | Leshem Y Y Wills R B H Ku V V V | 1998 | Plant Physiol Biochem1998，36，11： | 1 |
| 13 | Calcium level affects the efficacy of supplemental microbial phytase in com-soybean meal diets of weanling pigs显示文摘 | Lei X G Ku P K Miller E R | 1994 | Animal Science1994，72，1： | 1 |
| 14 | Effect of 1 - methylcyclopropene on the storage life of broccoli 显示文摘 | Ku V V V Wills R B H | 1999 | Post - 3 Harvest Biol Technol1999，17，： | 1 |
| 15 | 1-Methylcyclopropene can differentially affect the postharvest life of strawberries exposed to ethylene 显示文摘 | Wills R B H Ben-Yehoshua S Ku V V V | 1999 | HortScience1999，34，： | 1 |
| 16 | Tumor-associated proteases and inhibitors in gastric cancer:analysis of prognostic impact and individual risk protease patters显示文摘 | Allgayer H Babic R Grutzner KU | 1998 | Clin Exp Metastasis1998，16，1： | 1 |
| 17 | Comparison of the clinical outcomes between fresh blastoeyst and vitrified - thawed blastocyst transfer显示文摘 | KU P Y LEE R K LIN S Y | 2012 | J Assist Reprod Genet2012，29，12： | 1 |
| 18 | Experimental and theoretical investigation of the residual stress distribution in brazed ceramic-steel components显示文摘 | Pintschovius L Pyka N Kuβmaul R | 1994 | Materials Science and Engineering1994，177，4： | 1 |
| 19 | African swine fever virus显示文摘 | Tulman E R Delhon G A Ku B K | 2009 | Curr Top Microbiol Immunol2009，328，： | 1 |
| 20 | Supplementing eomsoybean meal diets with microbial phytase linearly improves phytate phosphorus utilization by weanling pigs 显示文摘 | Lei X G Ku P K Miller E R | 1993 | J Anim Sci1993，71，12： | 1 |
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