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| 1 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 2 | Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction显示文摘We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT. | Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada Tatsuya Toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi | 2012 | World Journal of Gastroenterology2012，18，21： | 4 |
| 3 | Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma显示文摘 | Kitadai Y Sasaki T Kuwai T | 2006 | Am J Pathol2006，169，6： | 1 |
| 4 | Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma显示文摘 | Kuwai T Kitadai Y Tanaka S | 2004 | Oncol Rep2004，12，5： | 1 |
| 5 | Antiferromagnetic in the Kondo lattice compound Ce2PdaSi5 显示文摘 | Huo D X Sakurai J Kuwai T | 2002 | Phys Rev B2002，65，14： | 1 |
| 6 | Expression of p53 protein in esophageal squamous cell carcinoma:relation to hypoxia-inducible factor-1alpha,angiogene sis and apoptosis显示文摘 | Kimura S Kitadai Y Kuwai T | 2005 | Pathobiology2005，72，4： | 1 |
| 7 | Expression of hypoxia-inducible factor-1 alpha is associated with tumor vascularization in human colorectal carcinoma显示文摘 | Kuwai T Kitadai Y Tanaka S | 2003 | Int J Cancer2003，105，： | 1 |
| 8 | Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paraerine mechanisms 显示文摘 | Kuwai T Tanaka S Oue N | 2008 | Clin Cancer Res2008，14，： | 1 |
| 9 | Expression of hypoxia-inducible factor-1 alpha is associated with tumor vascularization in human colorectal carcinoma显示文摘 | Kuwai T Tanaka S Dulnet E | 2003 | Int J Cancer2003，105，2： | 1 |
| 10 | Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma显示文摘 | Kuwai T Kitadai Y Tanaka S | 2003 | Int J Cancer2003，105，2： | 1 |
| 11 | Mutation of the von Hippel- Lindau(VHL) gene in human coloreetal carcinoma: association with cytoplasmic accumulation of hypoxia-inducible factor( HIF)- lc显示文摘 | Kuwai T Kitadai Y Tanaka S | 2004 | Cancer Sei2004，95，2： | 1 |
| 12 | Isolation of monoamine oxidase inhibitors from Glycyrrhiza uralensis roots and the structure-activity relationship显示文摘 | Tanaka S Kuwai Y Tabata M | 1987 | Planta Med1987，53，1： | 1 |
| 13 | Expression of hypoxia - inducible factor - 1 alpha is associated with tumor vascularization in human colorectal carcinoma显示文摘 | Kuwai T Kitadai Y Tanaka S | 2003 | Int J Cancer2003，105，2： | 1 |
| 14 | Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma显示文摘 | Kitadai Y Sasaki T Kuwai T | 2006 | Am J Pathol2006，169，6： | 1 |
| 15 | Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma 显示文摘 | KITADAI Y ONOGAWA S KUWAI T | 2004 | Oncology Reports2004，11，2： | 1 |
| 16 | Expression of hypoxia-inducible factor-1 alpha is associated with tumor vascularization in human colorectal carcinoma显示文摘 | Kuwai T Kitadai Y Tanaka S | 2003 | Int J Cancer2003，105，2： | 1 |
| 17 | Antiferromagnetic in the Kondo lattice compound Ce2Pd3Si5显示文摘 | Huo D X Sakurai J Kuwai T | 2002 | Physical Revivew B2002，65，14： | 1 |
| 18 | Electric,magnetic,and thermal properties of Ce2NiGe3:A Kondo lattic compound showing spin glass behavior显示文摘 | Huo D Skurai J Kuwai t Isikawa Y Q Lu | 2001 | Physical Revivew B2001，64，22： | 1 |
| 19 | Clinical significance of Fhit expression in development of co lo rectal carcinoma of various macroscopic types显示文摘 | Kuwai T Tanaka S Kaio E | 2003 | Intl J Mol Med2003，12，4： | 1 |
| 20 | Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy 显示文摘 | Kuwai T Nakamura T Sasaki T | 2008 | Clin Exp Metastasis2008，25，4： | 1 |
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