|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Quantification and control of the sulfur c(2 × 2) superstructure on {100} (100) Ni for optimization of YSZ, CeO2 and SrTiO3 seed layer texture显示文摘 | Cantoni C Christen D K Heatherly L | 2002 | Journal of Materials Research2002，17，10： | 1 |
| 3 | Vitamin D and diabetes: its importance for beta cell and immune function 显示文摘 | Wolden-Kirk H Overbergh L Christen HT | 2011 | Mol Cell Endocrinol2011，347，12： | 1 |
| 4 | Cardiovascular and survival effects of sympatho-inhibitors in adriamycin-induced cardiomyopathy in rats显示文摘 | Thomas L Bellmont S Christen MO | 2004 | Fundam Clin Pharmacol2004，18，6： | 1 |
| 5 | Ionic regulation of the plasma membrane potential of rainbow trout spermatozoa:role in initiation of sperm motility显示文摘 | GATTIJ L BILLARD R Christen R | 1990 | Cell Physiol1990，143，： | 1 |
| 6 | Assessment of effluent contaminants from three facilities discharging marcellus shale wastewater to surface waters in pennsylvania显示文摘 | Ferrar K J Michanowicz D R Christen C L | 2013 | Environmental Science & Technology2013，47，7： | 1 |
| 7 | The urokinasetype plasminogen activator system in cancer metastasis: a review 显示文摘 | Andreasen PA Kjoler L Christen L | 1997 | Int J Cancer1997，72，： | 1 |
| 8 | Thermol stability of lipase and protease of Pseudomonas fluorescens 27 produced in various broths显示文摘 | Christen G L Marshall R T | 1984 | J Dairy Sci1984，67，： | 1 |
| 9 | Thermal conductivity of solid argon显示文摘 | Christen D K Pollack G L | 1975 | Physical Review B1975，12，8： | 1 |
| 10 | Intravitreal bevacizumab for treatment of uveitic macular edema显示文摘 | Cordero Coma M Sobrin L Onal S Christen W Foster CS | 2007 | Ophthalmology2007，114，： | 1 |
| 11 | The extent of perfusion- F18-fluorodeoxyglucose positron emission tomography mismatch determines mortality in medically treated patients with chronic ischemic left vcntricular dysfunction显示文摘 | Desideri A Cortigiani L Christen AI | 2005 | J Am Coil Cardiol2005，46，7： | 1 |
| 12 | Predicting drug absorption from molecular surface properties based on molecular dynamics simulations显示文摘 | Krarup LH Christen sen IT FIovgaard L | 1998 | Pharm Res1998，15，07： | 1 |
| 13 | Van Wyk and Grumbach syndrome : an unusual form of precocious puberty显示文摘 | Christens A Sevenants L Toelen J | 2014 | Gynecol Endocrinol2014，30，4： | 1 |
| 14 | Thermal conductivity of solid argon 显示文摘 | Christen D K Pollack G L | 1975 | Phys Rev B1975，12，： | 1 |
| 15 | Selected Properties of Lipase and Protease of Pseudomonas fluorescens 27 Produced in Four Media显示文摘 | G L Christen R T Marshall | 1984 | Dairy Sci1984，67，： | 1 |
| 16 | Assess- ment of Effluent Contaminants from Three Facilities Dischar- ging Marcellus Shale Wastewater to Surface Waters in Penn- sylvania 显示文摘 | Ferrar K J Michanowicz D R Christen C L | 2013 | Environmental Science & Technology2013，47，7： | 1 |
| 17 | Matrix metalloproteinase-9 in pneumococcal meningitis:activation via an oxidative pathway显示文摘 | Meli D N Christen S Leib S L | 2003 | J Infect Dis2003，187，9： | 1 |
| 18 | Nonaqueous capillary electrophoresis for the analysis of selected tropane alkaloids in a plant extract 显示文摘 | Cherkaoui S Mateus L Christen P | 1999 | Chromatographia1999，49，： | 1 |
| 19 | 显示文摘 | BRACHET A CHRISTEN P VEUTHEY J L | 2002 | Phytochem Anal2002，13，3： | 1 |
| 20 | New trends in extraction, identification and quantification of artemisinin and its derivatives显示文摘 | Christen P Veuthey J L | 2001 | Current Medicinal Chemistry2001，8，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员