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| 1 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 2 | The Use of Preoperative Endoscopic Tattooing in Laparoscopic Colorectal Cancer Surgery for Endoscopically Advanced Tumors: A Prospective Comparative Clinical Study显示文摘 | Ivan Arteaga-González MD Antonio Martín-Malagón MD Eudaldo M. López-Tomassetti Fernández MD Javier Arranz-Durán MD Adolfo Parra-Blanco MD David Nicolas-Perez MD Enrique Quintero-Carrión MD Hermogenes Díaz Luis MD Angel Carrillo-Pallares MD PhD | 2006 | World Journal of Surgery2006，，4： | 2 |
| 3 | Vascular Dementia:A Contemporary Review of Epidemiology,Diagnosis,Prevention and Treatment显示文摘 | David L Nyenhuis PhD Philip B | 1998 | Journal of the American Geriatrics Society1998，46，11： | 1 |
| 4 | Tumor stem cells显示文摘 | László Kopper MD PhD DSc Melinda Hajdú | 2004 | Pathology & Oncology Research2004，，2： | 1 |
| 5 | Newborn hearing screening in the NICU:profile of failed auditory brainstem response/passed otoacoustic emission显示文摘 | Abbey L Berg PhD Jaclyn B | 2005 | Pediatrics2005，116，4： | 1 |
| 6 | Maternal diabetes mellitus and infant malformations显示文摘 | Jeanne S Sheffield MD Erin L Butler-Koster MD Brian M Casey MD Donald D McIntire PhD Kenneth J Leveno MD | 2002 | Obstetrics & Gynecology2002，100，： | 1 |
| 7 | Role of Whole Foods in Promoting Hy- dration after Exercise in Humans 显示文摘 | Rick L Sharp PhD | 2007 | Journal of the Ameri- can College of Nutrition2007，26，5： | 1 |
| 8 | EEG asymmetry analysis of the left and right brain activities during simple versus complex arithmetic learning显示文摘 | PHD H K PHD J C PHD E L | 2009 | Journal of Neurotherapy2009，13，2： | 1 |
| 9 | How well do their dietary patterns meet the healthy people 2010 objectives显示文摘 | CHERYL L PERRY PHD MAUREEN T | 2002 | Archives of Pediatrics & Adolescent Medicine2002，156，： | 1 |
| 10 | Body mass index and mortality : a meta-analysis based on person-level data from twenty-six observational studies 显示文摘 | Daniel L Mcgee PHD | 2005 | Ann Epidemiol2005，15，2： | 1 |
| 11 | On the reliability of predictions on Covid-19 dynamics: A systematic and critical review of modelling techniques显示文摘Since the emergence of the novel 2019 coronavirus pandemic in December 2019(COVID-19),numerous modellers have used diverse techniques to assess the dynamics of transmission of the disease,predict its future course and determine the impact of different control measures.In this study,we conducted a global systematic literature review to summarize trends in the modelling techniques used for Covid-19 from January 1st,2020 to November 30th,2020.We further examined the accuracy and precision of predictions by comparing predicted and observed values for cumulative cases and deaths as well as uncertainties of these predictions.From an initial 4311 peer-reviewed articles and preprints found with our defined keywords,242 were fully analysed.Most studies were done on Asian(78.93%)and European(59.09%)countries.Most of them used compartmental models(namely SIR and SEIR)(46.1%)and statistical models(growth models and time series)(31.8%)while few used artificial intelligence(6.7%),Bayesian approach(4.7%),Network models(2.3%)and Agent-based models(1.3%).For the number of cumulative cases,the ratio of the predicted over the observed values and the ratio of the amplitude of confidence interval(CI)or credibility interval(CrI)of predictions and the central value were on average larger than 1 indicating cases of inaccurate and imprecise predictions,and large variation across predictions.There was no clear difference among models used for these two ratios.In 75%of predictions that provided CI or CrI,observed values fall within the 95%CI or CrI of the cumulative cases predicted.Only 3.7%of the studies predicted the cumulative number of deaths.For 70%of the predictions,the ratio of predicted over observed cumulative deaths was less or close to 1.Also,the Bayesian model made predictions closer to reality than classical statistical models,although these differences are only suggestive due to the small number of predictions within our dataset(9 in total).In addition,we found a significant negative correlation(rho=-0.56,p=0.021)between this ratio and the length(in days)of the period covered by the modelling,suggesting that the longer the period covered by the model the likely more accurate the estimates tend to be.Our findings suggest that while predictions made by the different models are useful to understand the pandemic course and guide policy-making,some were relatively accurate and precise while other not. | Janyce Eunice Gnanvi KolawoléValère Salako Gaëtan Brezesky Kotanmi Romain GlèlèKakaïPhD | 2021 | Infectious Disease Modelling2021，6，1： | 1 |
| 12 | How well do their dietary patterns meet the healthy people 2010 objectives显示文摘 | CHERYL L PERRY PHD MAUREEN T | 2002 | Archives of Pediatrics & Adolescent Medicine2002，156，： | 1 |
| 13 | An Internet-based program to improve self-management in adolescents with type 1 diabetes显示文摘 | Shelagh A Mulvaney PHD Russell L | | 0，，03： | 1 |
| 14 | The association of interleukin 6 with clinical and laboratory parameters of acute pelvic inflammatory disease显示文摘 | Richter H E PhD Robert L Holley M D | 1999 | Am J Obstetrics Gynecol1999，181，4： | 1 |
| 15 | Infection control practices to reduce airborne bacteria during total knee replacement:A hospital survey in four states 显示文摘 | Andrew L Miner MD Elena Losina PhD JN | 2005 | In-fect Control Hosp Epidemiol2005，26，12： | 1 |
| 16 | Online diabetes self-management program显示文摘 | Kate Lorig RN DrPH Maurice Green PHD Philip L | | 0，，06： | 1 |
| 17 | Endoscopic sugery for early glottic carcinoma显示文摘 | ROBERT L FERRIS M D PHD ALFFRED SIMENTAL M D | 2003 | Otol Head Neck Surg2003，14，： | 1 |
| 18 | Redistribution of myocardial blood flow with Topical nitroglycerin in patients with coronary artery disease显示文摘 | Ernest L Fallen MD FRCP(c) Claude nahmias Phd | 1995 | Circulation1995，91，5： | 1 |
| 19 | The Efficacy of Octreotide in Pancreatic and Intestinal Changes: Radiation-Induced Enteritis in Animals显示文摘 | Vakur Olga? PhD Ye?im Erbil Umut Barbaros MD Serdar ?ztezcan Murat Giri? MSc Hakan Kaya MD Hatice Bilge Semra Güler PhD Gül?in Toker | 2006 | Digestive Diseases and Sciences2006，，1： | 1 |
| 20 | Changes in automated complete blood cell count and differential leukocyte count results induced by storage of blood at room temperature显示文摘 | Gene L Gulati PhD Lawrence J | 2002 | Archives of Pathology and Laboratory Medicine2002，126，： | 1 |
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