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11篇 您的检索式:作者名="L.Baker"
    题名 作者 年代 出处 被引量
1Food Safety Attitudes in College Students:A Structural Equation Modeling Analysis of a Conceptual Model显示文摘Rachelle Booth Magaly Hernandez Erica L.Baker 0,,05:1
2Mode S System Design and Architecture显示文摘JOHN L.BAKER 0,,11:1
3Hepatic Microcirculatory Dysfunction During Cholestatic Liver Injury in Rats显示文摘YOSHIYAITO NANCY W.BETHEA GREGORY L.BAKER MARGARET K.MCCUSKEY RENATEURBASCHEK ROBERT S.MCCUSKEY 2010Microcirculation2010,,5:1
4Preschool children with intellectual disability: syndrome specificity, behaviour problems, and maternal well‐being显示文摘A. S.Eisenhower B. L.Baker J.Blacher 2005Journal of Intellectual Disability Research2005,,9:1
5In Memoriam:Dr.John M.Laflen显示文摘The soil erosion research and soil and water conservation global community lost a treasured member on November 20,2020,when Dr.John Matthew Laflen(Fig.1)died.Always one with a friendly welcoming smile,John had hundreds of friends,both personally and professionally throughout the world.This article includes many of his professional and scientific contributions,and impacts from his research and outreach activities.Dennis C.Flanagan Richard M.Cruse James L.Baker Paige Chyu 2021International Soil and Water Conservation Research2021,9,4:0
6Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration显示文摘Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global blindness.We report that AβOs induce RPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMD that is currently untreatable.We demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that RPE expression of the purinergic ATP receptor P2RX7,an upstream mediator of NLRP3 inflammasome activation,is required for AβO-induced RPE degeneration.Two classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NRTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE degeneration.These findings crystallize the importance of P2RX7 and NLRP3 in a disease-relevant model of AMD and identify inflammasome inhibitors as potential treatments for GA.Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion Jan M.Deussing Srinivas R.Sadda Bradley D.Gelfand Jayakrishna Ambati 2021Signal Transduction and Targeted Therapy2021,6,5:0
7AB062. Cortical state contribution to neuronal response variability显示文摘Background:Visual cortex neurons often respond to stimuli very differently on repeated trials.This trial-by-trial variability is known to be correlated among nearby neurons.Our long-term goal is to quantitatively estimate neuronal response variability,using multi-channel local field potential(LFP)data from single trials.Methods:Acute experiments were performed with anesthetized(Remifentanil,Propofol,nitrous oxide)and paralyzed(Gallamine Triethiodide)cats.Computer-controlled visual stimuli were displayed on a gamma-corrected CRT monitor.For the principal experiment,two kinds of visual stimuli were used:drifting sine-wave gratings,and a uniform mean-luminance gray screen.These two stimuli were each delivered monocularly for 100 sec in a random order,for 10 trials.Multi-unit activity(MUA)and LFP signals were extracted from broadband raw data acquired from Area 17 and 18 using A1X32 linear arrays(NeuroNexus)and the OpenEphys recording system.LFP signal processing was performed using Chronux,an open-source MATLAB toolbox.Current source density(CSD)analysis was performed on responses to briefly flashed full-field stimuli using the MATLAB toolbox,CSDplotter.The common response variability(global noise)of MUA was estimated using the model proposed by Scholvinck et al.[2015].Results:On different trials,a given neuron responded with different firing to the same visual stimuli.Within one trial,a neuron’s firing rate also fluctuated across successive cycles of a drifting grating.When the animal was given extra anesthesia,neurons fired in a desynchronized pattern;with lighter levels of anesthesia,neuronal firing because more synchronized.By examining the cross-correlations of LFP signals recorded from different cortical layers,we found LFP signals could be divided to two groups:those recorded in layer IV and above,and those from layers V and VI.Within each group,LFP signals recorded by different channels are highly correlated.These two groups were observed in lighter and deeper anesthetized animals,also in sine-wave and uniform gray stimulus conditions.We also investigated correlations between LFP signals and global noise.Power in the LFP beta band was highly correlated with global noise,when animals were in deeper anesthesia.Conclusions:Brain states contribute to variations in neuronal responses.Raw LFP correlation results suggest that we should analyze LFP data according to their laminar organization.Correlation of low-frequency LFP under deeper anesthesia with global noise gives us some insight to predict noise from single-trial data,and we hope to extend this analysis to lighter anesthesia in the future.Shangge Jiang Guangxing Li Curtis L.Baker 2018Annals of Eye Science2018,,1:0
8AB068. Texture density aftereffect can be bidirectional显示文摘Background:It has been suggested that adaptation to texture density only ever reduces,i.e.,never increases,perceived density,implying that density adaptation is‘uni-directional’and that texture density is coded as a scalar attribute(Durgin&Huk,1997).However,we have recently shown that simultaneous density contrast,which describes the effect of a surround texture on the perceived density of a centre region,is‘bi-directional’-that is,not only do denser surrounds reduce perceived density of the center but sparser surrounds enhance it(Sun,Baker,&Kingdom,2016).Therefore,we decided to re-examine the directionality of density adaptation.Methods:We measured the density aftereffect in random dot patterns using a 2AFC matching procedure that established a point-of-subjective-equality(PSE)between an adapted test patch and an unadapted match patch.The adaptors and test were presented at the same position,either at top left or bottom right of the fixation.The match was presented at bottom left or top right correspondingly.These positions were fixed within a block and switched between blocks.Then,using sequential presentation,we measured the density aftereffect for a wide range of adaptor and test densities.Results:In the first experiment,we observed a unidirectional density aftereffect when test and match were presented simultaneously as in previous studies.However,when they were presented sequentially,bidirectionality was obtained.This bidirectional aftereffect remained when the presentation order of test and match was reversed(second experiment).In the third experiment,we used sequential presentation to measure the density aftereffect for a wide range of adaptor densities(0-73 dots/deg2)and test densities(1.6,6.4,and 25.6 dots/deg2).We found bidirectionality for all combinations of adaptor and test densities,consistent with our previous SDC results.Conclusions:In three experiments,we found that density adaptation is bidirectional when the test and match stimuli are presented sequentially.The unidirectional density adaptation reported in previous studies might have been due to effects arising from simultaneous presentation of test and match stimuli.Our evidence again supports the idea that there are density-selective channels in the visual system in line with our previous finding in SDC.Hua-Chun Sun Frederick A.A.Kingdom Curtis L.Baker 2018Annals of Eye Science2018,,1:0
9全球包装法规的基本原则及其标准化显示文摘全球包装法规的基本原则 包装应不能通过包装上偷工减料而使产品掺假,从而危及消费者;包装应不会减损食品的感观性状(味道/气味)。FDA(Food and Drug Administration美国食品与药品管理局)法规规定,再生材料中的化学污染物达到最大量时,将引发身体估计每日摄入量(EDI)但不超过1.5微克/人/天(膳食量为0.5ppb(DC)),FDA认为,这个水平可以忽略再生塑料污染物迁移的风险。Marilyn L.Baker 2010标准生活2010,,6:0
10COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history显示文摘Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb titers.Methods:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 vaccine.All major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb serology.Results:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded exercise.However,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent manner.Both groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid antigens.nAbs increased significantly during exercise only in the hybrid immunity group.Conclusion:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson 2024Journal of Sport and Health Science2024,13,1:0
11企业如何建立更有效的定价组织显示文摘在过去20年里,大多数企业已经认识到有效的定价对企业盈亏状况的影响。然而,光有这种认识还远远不够。要充分挖掘定价的全部潜力,就需要一种能推动定价绩效真正持续提高的基础架构。有了这种基础,企业就能通过创建深思熟虑的决策流程、专门的定价组织、能适当测评和奖励卓越定价的机制以及强有力的支持工具和系统,安排和改进各种定价活动。Walter L.Baker Michael V.Marn Craig C.Zawada 2010商学院2010,,11:0
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