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| 1 | Role of early life exposure and environment on neurodegeneration: implications on brain disorders显示文摘Neurodegenerative diseases such as Alzheimer’s disease(AD),Parkinson’s disease(PD),Amyotrophic lateral sclerosis(ALS)and retinal degeneration have been studied extensively and varying molecular mechanisms have been proposed for onset of such diseases.Although genetic analysis of these diseases has also been described,yet the mechanisms governing the extent of vulnerability to such diseases remains unresolved.Recent studies have,therefore,focused on the role of environmental exposure in progression of such diseases especially in the context of prenatal and postnatal life,explaining how molecular mechanisms mediate epigenetic changes leading to degenerative diseases.This review summarizes both the animal and human studies describing various environmental stimuli to which an individual or an animal is exposed during in-utero and postnatal period and mechanisms that promote neurodegeneration.The SNPs mediating gene environment interaction are also described.Further,preventive and therapeutic strategies are suggested for effective intervention. | Shweta Modgil Debomoy K Lahiri Vijay L Sharma Akshay Anand | 2014 | Translational Neurodegeneration2014，3，1： | 5 |
| 2 | Reactivation of hepatitis B after liver transplantation: Current knowledge, molecular mechanisms and implications in management显示文摘Chronic hepatitis B(CHB) is a major global health problem affecting an estimated 350 million people with more than 786000 individuals dying annually due to complications, such as cirrhosis, liver failure and hepatocellular carcinoma(HCC). Liver transplantation(LT) is considered gold standard for treatment of hepatitis B virus(HBV)-related liver failure and HCC. However, post-transplant viral reactivation can be detrimental to allograft function, leading to poor survival. Prophylaxis with high-dose hepatitis B immunoglobulin(HBIG) and anti-viral drugs have achieved remarkable progress in LT by suppressingviral replication and improving long-term survival. The combination of lamivudine(LAM) plus HBIG has been for many years the most widely used. However, life-long HBIG use is both cumbersome and costly, whereas long-term use of LAM results in resistant virus. Recently, in an effort to develop HBIG-free protocols, high potency nucleos(t)ide analogues, such as Entecavir or Tenofovir, have been tried either as monotherapy or in combination with low-dose HBIG with excellent results. Current focus is on novel antiviral targets, especially for covalently closed circular DNA(ccc DNA), in an effort to eradicate HBV infection instead of viral suppression. However, there are several other molecular mechanisms through which HBV may reactivate and need equal attention. The purpose of this review is to address post-LT HBV reactivation, its risk factors, underlying molecular mechanisms, and recent advancements and future of anti-viral therapy. | Ranjit Chauhan Shilpa Lingala Chiranjeevi Gadiparthi Nivedita Lahiri Smruti R Mohanty Jian Wu Tomasz I Michalak Sanjaya K Satapathy | 2018 | World Journal of Hepatology2018，10，3： | 5 |
| 3 | Standing waves in a non-linear 1D lattice: Floquet multipliers Krein signatures, and stability 显示文摘 | Subhendu Panda Anindita Lahiri Tarun K Roy | 2005 | Physica D2005，210，： | 1 |
| 4 | Meatallurgical and Materials Transactions-显示文摘 | Lahiri A K | 1996 | 27(10): 7571996，27，10： | 1 |
| 5 | Cold Model Study of Raceway Under Mixed Particle Conditions显示文摘 | Sastry G S S R K Gupta G S Lahiri A K | 2003 | Ironmaking and Steelmaking2003，30，1： | 1 |
| 6 | Chrome -free tannage by sequential treatment with synthetic resinsnd aluminium or titanium显示文摘 | Gangopadhyay S Lahiri S Gangopadhyay P K | 2000 | SLTC2000，84，2： | 1 |
| 7 | Glucagon-like peptide-1decreases endogenous amyloid-beta peptide(Abeta)levels and protects hippocampal neurons from death induced by Abeta and iron显示文摘 | Perry T Lahiri DK Sambamurti K | 2003 | J Neurosci Res2003，72，5： | 1 |
| 8 | DNA isolation by a rapid method from human blood sample:Effects of MgCl2, EDTA, storage time, and temperature no DNA yield and quality 显示文摘 | Lahiri D K Schuable B | 1993 | Biochem Genet1993，32，78： | 1 |
| 9 | Development of a hybird artificial nerual network and genetic algoirthm model for regime identification of slurry transport in pipelines 显示文摘 | Lahiri S K Ghanta K C | 2009 | Chemieal Product and Process Modeling2009，4，1： | 1 |
| 10 | storage time, and temperature on DNA yield and quality显示文摘 | LAHIRI D K SCHUABEL B DNA isolation by a rapid method from human blood samples: Effects of MgCl2 EDTA | 1993 | Biochem Genet1993，31，： | 1 |
| 11 | Design Space Exploration for Optimizing On-Chip Communication Architectures 显示文摘 | K Lahiri A Raghunathan S Dey | 2004 | IEEE TCAD (S0278-0700)2004，23，6： | 1 |
| 12 | Cold model study of raceway under mixed particle conditions显示文摘 | Sastry G S S R K Gupta G S Lahiri A K | 2003 | Ironmaking and Steelmaking2003，30，1： | 1 |
| 13 | Is provision of healthcare sufficient to ensure better access? An exploration of the scope for public-private partnership in India显示文摘 | I)utta S Lahiri K | 2015 | Int J Health Policy Manag2015，4，7： | 1 |
| 14 | Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease显示文摘 | Sambamurti K Greig NH Lahiri DK | | 0，，01： | 1 |
| 15 | A critical a- nalysis of new molecular targets and strategies for drug de- velopments in Alzheimer's disease 显示文摘 | Lahiri DK Farlow MR Sambamurti K | 2003 | Curr Drug Targets2003，4，： | 1 |
| 16 | Advances in the cellu lar and molecular biology of the beta-amyloid protein in Alzheimer's disease显示文摘 | Greig NH Lahiri DK | 2002 | Neuromolecular Med2002，1，： | 1 |
| 17 | Estimation of Vis cosities of High Alumina Blast Furnace Slags 显示文摘 | Shankar A Gornerup M Lahiri A K | 2007 | Ironmaking and Steelmaking2007，34，6： | 1 |
| 18 | Pure red cell aplasia associated with thymoma显示文摘 | LAHIRI T K AGRAWAL D AGRAWAL K | | 0，，： | 1 |
| 19 | Water modelling study of the jet character- istics in a continuous casting mould显示文摘 | Gupta D Lahiri A K | 1992 | Steel Research1992，63，5： | 1 |
| 20 | Cold Model Study of the Surface Profile in a Continuous Slab Casting Model: Effect of Second Phase 显示文摘 | Gupta D Lahiri A K | 1996 | Metallurgical and Material Transactions1996，27，8： | 1 |
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