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| 1 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 2 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 3 | 含有菊粉但不含羽扇豆的饲粮有助预防实验诱导的猪痢疾显示文摘猪痢疾是一种传染性黏膜出血的腹泻疾病,由定植于肠道的猪痢疾短螺旋体引起,能够诱发盲肠和结肠发炎。据报道饲料中添加菊苣根和甜羽扇豆可预防猪痢疾。本试验旨在验证是菊苣根中的菊粉而不是羽扇豆中的半乳糖起到保护作用的假设。 | Hansen C F Phillips N D La T.(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 2 |
| 4 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 5 | 高血压患者同型半胱氨酸水平升高与代谢综合征和心血管事件相关显示文摘高同型半胱氨酸(homocysteine,Hcy)血症和代谢综合征(metabolic syndrome,MS)是明确的心血管危险因素,常与高血压相关。然而血浆Hcy与MS、胰岛素抵抗相关性存在争议,且在高血压患者中的研究较少。该研究探讨高血压患者Hcy与MS和心脑血管事件的相关性。 | Catena C Colussi G Nait F Capobianco F Sechi LA 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，1： | 2 |
| 6 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 7 | Infection of tick cells and bovine erythroeytes with one genotype of the intracellular Ehrlichia Anaplasma marginale excludes infection with other genotypes显示文摘 | DE LA FUENTE J GARCIA-GARCIA J C BLOUIN E F | 2002 | Clin Diagn Lab Immunol2002，9，3： | 1 |
| 8 | Inducible nitric oxide synthase gene expression in brain following cerebral ischemia显示文摘 | Iadeco la C Zhang F Xu S | 1995 | J Cereb Blood Flow Metab1995，15，3： | 1 |
| 9 | Inci- dence of redetachment 6 months after scleral buckling surgery 显示文摘 | GOEZINNE F LA HEIJ E C BERENDSCHOT T T | 2010 | Acta Ophthalmol2010，88，2： | 1 |
| 10 | Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects显示文摘 | Ortiz LA Gambelli F McBride C | | 0，，： | 1 |
| 11 | Evaluation of extraction and purification methods for obtaining PCR-amplificable DNA from compost for microbial community analysis显示文摘 | La Montagne M G Michel F C Holden P A | 2002 | Micro Methods2002，49，： | 1 |
| 12 | Rip currents: A process of geological importance显示文摘 | Shepard F P Emery K O La Fond E C | 1941 | The Journal of Geology1941，，： | 1 |
| 13 | Diet and uterine myomas显示文摘 | Chiaffarino F Parazzini F La Vecchia C | 1999 | Obstet Gynecol1999，94，3： | 1 |
| 14 | Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects显示文摘 | Ortiz LA Gambelli F McBride C | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 15 | Molecular cloning and sequencing of a gene encoding biologically active porcine alpha-interferon显示文摘 | F Lefevre C La Bonnaardiere | 1986 | Interferon Res1986，6，4： | 1 |
| 16 | Multivariate multi-scale permutation entropy for complexity analysis of Alzheimer's disease EEG显示文摘 | Morabito F C Labate D La Foresta F | 2012 | Entropy2012，14，7： | 1 |
| 17 | Hepatoceilular carcinoma epi- demiology显示文摘 | Bosetti C Turati F La Vecchia C | 2014 | Best Pract Res Clin Gastroenterol2014，28，： | 1 |
| 18 | Naphtho isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors显示文摘 | DA SETTIMO F PRIMOFIORE G LA MOTTA C | 2005 | J Med Chem2005，48，22： | 1 |
| 19 | Rate dependent damage for concrete in dynamics 显示文摘 | Dube J F Pijaudier-Cabot G La Borderie C | 1996 | Journal of Engineering Mechanics ASCE1996，122，10： | 1 |
| 20 | Mesenehmyal stem cell engraftment in lung is enhance in response to bleomycin exposure and ameliorate 1 is fibrotle effect 显示文摘 | Ortiz LA Gmabelli F Me Bride C | 2003 | Proc Natl Acad Se USA2003，100，14： | 1 |
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