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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 3 | 二十碳五烯酸对三种肝癌细胞系作用的实验研究显示文摘目的 探讨二十碳五烯酸 (eicosapentaenoicacid ,EPA)对 3种肝癌细胞系作用。方法EPA作用于HepG2 (携带有野生型p5 3基因 )、Huh7(携带有突变型p5 3基因 )和Hep3B(p5 3基因缺失 )这 3种肝癌细胞系 ,通过细胞计数、DNA电泳、流式细胞技术和末端转移酶标记技术等来检测EPA对这 3种细胞系的作用和可能的机制。结果 EPA主要是通过诱导HepG2肝癌细胞系的细胞凋亡来抑制其生长 ,而且这种抑制作用呈现出时间和剂量依赖的关系 ,而且同时发现EPA对于Huh7和Hep3B这两种肝癌细胞系无明显抑制作用。结论 细胞凋亡的诱导可能是EPA抑制HepG2肝癌细胞系生长的主要机制 ,而且p5 3基因可能参与EPA诱导HepG2细胞系细胞凋亡的过程。 | 王蓬 陈孝平 PBS Lai CK leow Joseph W Y Lau | 2001 | 中华普通外科杂志2001，16，1： | 4 |
| 4 | Imaging of gastrointestinal stromal tumor显示文摘 | Lau S Tam KF Kam CK | 2004 | Clin Radiol2004，59，5： | 1 |
| 5 | rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats 显示文摘 | Tsui TY Lau CK Ma J | 2005 | Hepatology2005，42，2： | 1 |
| 6 | Prospective randomized comparative evaluation of proximal valve polyurethane and distal valve silicone peripherally inserted central catheters 显示文摘 | Ong CK Venkatesh SK Lau GB | 2010 | J Vasc Interv Radiol2010，21，8： | 1 |
| 7 | Minimal residual disease-based risk stratification in chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction显示文摘 | Cheng SH Lau KM Li CK | | 0，，07： | 1 |
| 8 | Allograft inflammatory factor- 1 is crucial for the survival and pro-inflammatory activity of mac- rophages 显示文摘 | Yang ZF David WH Lau CK | 2010 | International Immunology2010，22，11： | 1 |
| 9 | Radiation-induced petrous internal carotid artery aneurysm显示文摘 | Lau WY Chow CK | 2005 | Ann Otol Rhinol Laryngol2005，114，12： | 1 |
| 10 | Inhibition of mTORenhances chemosensitivity in hepatocellular carcinoma显示文摘 | Tam KH Yang ZF Lau CK | 2009 | Cancer Lett2009，273，20： | 1 |
| 11 | Beneficial effects of cholesterol-lowering therapy on coronary endotheliurn-de-pendent relaxation in hypercholesterolaemic patients显示文摘 | Leung WH Lau CP Wong CK | 1993 | Lancet1993，41，8859： | 1 |
| 12 | An Akt/hypoxia-inducible f&ctor- 1 alpha/platelet-derived growth f&ctor-BB autocrine loop mediates hypoxia- induced chemoresistance in liver cancer ceils and tumorigenic hepatic progenitor cells显示文摘 | Lau CK Yang ZF Ho DW | 2009 | Clin Cancer les2009，15，10： | 1 |
| 13 | guidelines for the assessment and management of nonalcoholic fatty liver dis- case in the Asia-Pacific region: executive summary 显示文摘 | Farrrn GC Chitturi S Lau CK | 2007 | J Gastroenterol Hepatol2007，22，： | 1 |
| 14 | Immune system and hepatitis B virus infection显示文摘 | HUI CK LAU GK | 2005 | J Clin Virol2005，34，1： | 1 |
| 15 | Peginterferon-alpha 2a (40 kD)(Pegasys) for hepatitis B显示文摘 | HUI CK LAU GK | 2005 | Expert Rev Anti Infect Ther2005，3，4： | 1 |
| 16 | Inhibition of mTOR enhances chemosensitivity in hepatocellular carcinoma显示文摘 | Tam KH Yang ZF Lau CK | 2009 | Cancer Lett2009，273，2： | 1 |
| 17 | Ventricular rate-adaptive pacing in elderly显示文摘 | Lau CP Wong CK Tai YT | 1992 | Eur Heart J1992，13，7： | 1 |
| 18 | Skin involvement in invasive breast carcinoma:safety of skin-sparing mastectomy显示文摘 | Ho CM Mak CK Lau Y | 2003 | Ann Surg Oncol2003，10，2： | 1 |
| 19 | Advances in immunomodulating therapy of HBV infection 显示文摘 | Hui CK Lau GK | 2005 | Int J Mect Sci2005，2，1： | 1 |
| 20 | Use of non - invasive positive- pressure ventilation for acute respiratory failure: prospective study 显示文摘 | Cheung MT Yarn LY Lau CW Ching CK Lee CH | 2000 | Hog Kong Med J2000，6，4： | 1 |
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