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| 1 | 北京市41~47岁人群出生时发育指标与成年期糖耐量减低的关系显示文摘目的 探讨中国人群中是否存在低出生指标与成年期非胰岛素依赖性糖尿病( N I D D M)和糖耐量减低( I G T) 的联系。方法 对1948 年7 月~1954 年底在北京协和医院出生的628 名单生子进行追访调查,摘录出生记录,并进行身体测量和标准口服葡萄糖耐量试验。结果 N I D D M 和 I G T患病率随出生体重、出生体重指数(ponderal index, P I) 和头围测量值的上升而下降。出生消瘦( P I< 24kg/m3) 伴成年肥胖( B M I≥75 百分位值) 组患病率最高(43 .8 % ) ;出生时脂肪较多( P I≥28 kg/m3) 且成年消瘦( B M I< 25 百分位值) 组患病率最低(8 .3 % ) 。母亲孕早、晚期 B M I与子女成年期糖负荷后2 小时血糖浓度呈负相关。此外,出生体重、 P I和头围还与空腹和糖负荷后2 小时血浆胰岛素、3233 裂解胰岛素原水平呈负相关。对调查对象目前的 B M I、生活习惯和经济水平进行调整后,上述出生指标与成年期糖耐量和胰岛素间的联系依然存在。结论 中国人群中存在低出生指标与成年期 N I D D M 和 I G T的联系,其机制可能是通过母亲孕前低 B M I导致胎儿营养不良,产生胰岛? | 米杰 Law CM 张孔来 Barker DJP 刘善英 Osmond C 徐红健 沈宜 柳军 徐永芳 | 1999 | 中华预防医学杂志1999，33，4： | 21 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | 立即行动 防治脑卒中显示文摘背景和目的:系统回顾性研究近40年的脑卒中病残率和早期病死率,以期更新当前对脑卒中长期趋势的认识。方法:应用近4JD年(1970--2008年)发表的56个人群基础脑卒中发病率和早期病死率(21d至1个月)的研究资料做系统回顾。研究人群是2个国家经济收入组(按世界银行国家分类的高经济收入国家和低一中经济收入国家,我国属后者,年人均收入为936~3705美元;高收入国家为11456美元或更高)。 | Feigin VL Lawes CM Bennett DA 李新 王纪佐 | 2009 | 中华神经科杂志2009，42，9： | 2 |
| 4 | Blood pressure and stroke:an overview of published reviews显示文摘 | Lawes CM Bennett DA Feigin VL | 2004 | Stroke2004，35，6： | 1 |
| 5 | Global burden of blood-pressure-related disease: 2001 显示文摘 | Lawes CM Vander Hoom S Rodgers A | 2008 | Lancet2008，371，9623： | 1 |
| 6 | Blood pressure and cardiovascular disease in the Asia Pacific region显示文摘 | Lawes CM Rodgers A Bennett DA | 2003 | J Hypertens2003，21，4： | 1 |
| 7 | Global burden of blood pressuewr-raleted disease 2001显示文摘 | Lawes CM | 2008 | Lancet2008，371，： | 1 |
| 8 | Biosynthesis and degradation of collagen in X-irradiated mouse lung显示文摘 | Walklin CM Freedman RB Law MP | 1987 | Radiat Res1987，112，2： | 1 |
| 9 | Global burden of bloodpressure-related disease,2001显示文摘 | Lawes CM Vander Hoorn S Rodgers A | 2008 | Lancet2008，371，9623： | 1 |
| 10 | Reducing attention deficits after stroke using attention process training:a randomized controlled trial显示文摘 | Barker-Collo SL Feigin VL Lawes CM | 2009 | Stroke2009，40，10： | 1 |
| 11 | The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature显示文摘 | Huxley RR ShieU AW Law CM | 2000 | J Hypertens2000，18，7： | 1 |
| 12 | Worldwide stroke incidence and early case fatality reported in 56 population-based studies:a systematic review显示文摘 | Feigin VL Lawes CM Bennett DA | 2009 | Lancet Neurol2009，8，： | 1 |
| 13 | The rnle of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature显示文摘 | Huxley RR Shiell AW Law CM | 2000 | J Hypertens2000，18，： | 1 |
| 14 | Worldwide stroke inci- dence and early ease fatality reported in 56 population-based studies: a systematic review显示文摘 | Feigin VL Lawes CM Bennett DA | 2009 | Lancet Neurol2009，8，4： | 1 |
| 15 | Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk显示文摘 | Jackson R Lawes CM Bennett DA | 2005 | Lancet2005，365，9457： | 1 |
| 16 | Worldwide stroke incidence and early case fatality reported in 56 population-based studies:a systematic review显示文摘 | Feigin VL Lawes CM Bennett DA | 2009 | Lancet Neurol2009，8，4： | 1 |
| 17 | Blood pressure and stroke:an overview of published reviews显示文摘 | Lawes CM Bennett DA Feiqin VL | 2004 | Stroke2004，35，4： | 1 |
| 18 | Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration:comparative risk assessment显示文摘 | Lawes CM Vander Hoom S | 2006 | Lancet2006，368，： | 1 |
| 19 | Smoking and tuber eulosis among the elderly in Hong Kong显示文摘 | Leung CC Li T Lain TH Yew WW Law WS Tam CM Chan WM Chan CK Ho KS Chang KC | 2004 | Am J Respir Crit Care Med2004，170，9： | 1 |
| 20 | The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature 显示文摘 | Huxley RR Shiell AW Law CM | 2000 | Journal of Hypertension2000，18，： | 1 |
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