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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 2 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 3 | Functional studies of mesenchymal stem cells derived from adult human adipose tissue显示文摘 | Andrea Dicker Katarina Le Blanc Gaby ?str?m Vanessa van Harmelen Cecilia G?therstr?m Lennart Blomqvist Peter Arner Mikael Rydén | 2005 | Experimental Cell Research2005，，2： | 2 |
| 4 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 5 | ZSM-5 zeolite with enhanced acidic properties显示文摘 | Le Van Mao R Le T S Fairbain M Muntasar A Xiao S Denes G | | 0，，： | 2 |
| 6 | Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin显示文摘 | Gilard M Amaud B Le Gal G | 2006 | American College of Cardiology2006，4，11： | 1 |
| 7 | Prevalence of the poultry red mite (Dermanyssus gallinae ) in England显示文摘 | Fiddes M D Le Gresley S Parsons D G | 2005 | Vet Rec2005，157，8： | 1 |
| 8 | Antioxidative properties of bee pollen in selected plant species显示文摘 | M Le j a Mareczek A G wyzgloik | 2007 | Food Chemistry2007，，100： | 1 |
| 9 | Peripheral benzodiazepine binding sites:effect of PK 11195,1-2-chlorophenyl-N -methyl-N -(1-methylpropyl) -3-isoquinolinecarboxamide显示文摘 | Le Fur G Perrier M I Vaucher N | 1983 | Life Sci1983，32，16： | 1 |
| 10 | Prediction of pulmonary embolism in the emergency department; the revised Geneva score显示文摘 | Le Cal G Righini M Roy PM | 2006 | Ann Inern Med2006，144，3： | 1 |
| 11 | Systematic review:the Trousseau syndrome revisited:should we screen extensively for cancer in patients with venous thromboembolism?显示文摘 | Cartier M Le Gai G Wells PS | 2008 | Ann Intern Med2008，149，： | 1 |
| 12 | Development of primary branches and crown profile of Fraxinus escelsior显示文摘 | CLUZEAU C LE G N OTTORINI J M | 1994 | Can J For Res1994，24，： | 1 |
| 13 | Pre- dicting effects of cations on copper toxicity to lettuce (Lactuca sativa) by the biotic ligand model 显示文摘 | Le T T Y Peijnenburg W J G M Hendriks A J | 2012 | Environ- mental Toxicology and Chemistry2012，31，2： | 1 |
| 14 | A randomized, double - blind trial assessing the efficacy of single - dose perinatal nevirapine added to a standard zidovudine regimen for the prevention of mother - to - child transmission of HIV - 1 in Thailand 显示文摘 | Lallemant M Jourdain G Le Coeur S | 2004 | N Engl J Med2004，351，： | 1 |
| 15 | Use of a vectored vaccine against infectious bursal disease of chickens in the face of high-titrated maternal derived antibody 显示文摘 | Bublot M Pfitchard N Le G | 2007 | Comp Pahtol2007，137，： | 1 |
| 16 | lnfluente of omeprazol on the antiplatelet action of clopidogrel associated to aspirin 显示文摘 | Gilard M Arnaud B le Gal G | 2006 | J Thromb Haemost2006，4，： | 1 |
| 17 | Influence of water on the crispness of cereal based foods-acoustic, mechanical, and sensory studies 显示文摘 | ROUDAUT G DACREMONT C LE M M | 1998 | J Texture Stud1998，29，： | 1 |
| 18 | Quality of life in long- term cergieal cancer survivors: a population - based study 显示文摘 | Le Borgne G Mercier M Woronoff AS | 2013 | Gynecologic Oncology2013，129，1： | 1 |
| 19 | Contributions to accel-erating atmospheric C02 growth from economic activity, carbon intensi-ty, and efficiency of natural sinks显示文摘 | Canadell J G Le Quere C Raupach M R | 2007 | Proc Natl Acad Sci USA2007，104，18： | 1 |
| 20 | Diastereoselective synthesis of N-(alpha-aryl-alpha-hatoa cetyl) amino acid esters by acylation using 3-aryl-2,2 di cyanooxiranes显示文摘 | OGER F LE PIRONNEC M G GUERRO M | 1999 | Synthesis1999，，8： | 1 |
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