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| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Signaling and endocytosis: a team effort for cell migration显示文摘 | Le Roy C Wrana J L | 2005 | Dev Cell2005，9，2： | 1 |
| 4 | Optimizing the receiver maneuvers for bearings-only tracking显示文摘 | Le Cadre J P Michel S L | 1999 | Elsevier Science on Automatic1999，35，5： | 1 |
| 5 | Decreased resistin expression in mice with different sensitivities to a high-fat diet显示文摘 | Le Lay S L Boucher J Rey A | 2001 | Biochem Biophys Res Commun2001，289，： | 1 |
| 6 | Mutations in pro-moter region of thrombomodulin and venous thromboembolic dis-ease显示文摘 | Le Flem L Heard V Emmefich J | 1999 | Arterioscler Thromb Vase Biol1999，19，4： | 1 |
| 7 | Potential impacts of clean air regulations on system operations显示文摘 | Le K D Golden J L Stansberry C J | 1995 | IEEE Transactions on Power Systems1995，，： | 1 |
| 8 | The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration 显示文摘 | Le MAITRE C L FREEMONT A J HOYLAND J A | 2005 | Arthritis Res Ther2005，7，4： | 1 |
| 9 | Constitu-tive protease-activated receptor-2-mediated migrationof MDA MB-231 breast cancer cells requires both beta-arrestin-1 and-2 显示文摘 | GE L SHENOY S LE FKOWITZ R J | 2004 | J Biol Chem2004，279，55： | 1 |
| 10 | Performance and utilization of dietary energy and amino acids in piglets fed low protein diets显示文摘 | Le Bellego L Noblet J | 2002 | Livest Prod Sci2002，76，： | 1 |
| 11 | Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome显示文摘 | LE L Q KABAROWSKI J H WENG Z | 2001 | Immunity2001，14，5： | 1 |
| 12 | Amino acid nutrition and immune function in tumour-bearing rats:a comparison of glutamine-,arginine-and ornithine 2-oxoglutarate-supplemented diets显示文摘 | Robinson L E Bussiere F I Le Boucher J | 1999 | Clin Sci (Lond)1999，97，： | 1 |
| 13 | A group Ⅱ intron has invaded the genus Azotobacter and is inserted within the termination codon of the essential groEL gene显示文摘 | Ferat J L Le Gouar M Michel F | 2003 | Mol Microbiol2003，49，5： | 1 |
| 14 | Immaturity of microvessels in haemorrhagic plaques is associated with proteolytic degradation of angiogenic factors显示文摘 | Le Dall J Ho-Tin-Noé B Louedec L | | Cardiovascular Research0，，： | 1 |
| 15 | 显示文摘 | Le Moigne F Lamboley J L Vitry T | 2009 | J Neuroradiol2009，36，5： | 1 |
| 16 | Are plants useful as accumulation indicators of metal bioavailability? 显示文摘 | REMON E BOUCHARDON J L LE GU DARD M | 2013 | Environmental Pollution2013，175，： | 1 |
| 17 | Export of biogenic carbon to fish and to the deep ocean: the role of large planktonic mirophages显示文摘 | FORTIER L LE FeVRE J LEGENDRE L | 1994 | JournalofPlanktonResearch1994，16，： | 1 |
| 18 | Combined effect of low-frequency ultrasound and iontophoresis: applications for transdermal heparin delivery 显示文摘 | Le L Kost J Mitragotri S | 2000 | Pharm Res2000，17，： | 1 |
| 19 | Volatile components of dry-cured ham 显示文摘 | BERDAGUAE J L DENOYER C LE Q J L | 1991 | Journal of Agricultural and Food Chemistry1991，39，7： | 1 |
| 20 | Assessment of the genotox- ic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-bloek micronucleus assays 显示文摘 | Le Hegarat L Dumont J Josse R | 2010 | Mutagene- sis2010，25，6： | 1 |
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