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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | A hybrid intelligent system for predicting bank holding structures显示文摘 | R R Hashemi L A Le Blanc C T Rucks | 1998 | European Journal of Operational Research1998，109，： | 1 |
| 4 | Determinants of liver damage associated with intravenous methylprednisolone pulse therapy in Graves' ophthalmopathy 显示文摘 | Le Moli R Baldeschi L Saeed P | 2007 | Thyroid2007，17，4： | 1 |
| 5 | Constitu-tive protease-activated receptor-2-mediated migrationof MDA MB-231 breast cancer cells requires both beta-arrestin-1 and-2 显示文摘 | GE L SHENOY S LE FKOWITZ R J | 2004 | J Biol Chem2004，279，55： | 1 |
| 6 | Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA - G molecules 显示文摘 | Le Friec G Gins F Sebti Y Guilloux V Panganlt C Fauchet R Amiot L | 2004 | J Leukoc Biol2004，76，6： | 1 |
| 7 | Mucosal administration of three recombinant Mycobacterium bovis BCG-SIVmac251 strains to cynomolgus macaques induces rectal IgAs and boosts systemic cellular immune responses that are primed by intradermal vaccination显示文摘 | Mederle l Le Grand R Vaslin B | 2003 | Vaccine2003，21，2730： | 1 |
| 8 | Structure-property relationship in intumescent polymeric formulations containing wastezeolite-based material as a synergistic agent显示文摘 | R M Estevao L Le Bras M Delobel R | 2004 | European Polymer Journal2004，40，7： | 1 |
| 9 | Alien species alert: Crassostrea gigas (Pacific oyster) 显示文摘 | Miossec L Le Deuff R M Goulletquer P | 2009 | ICES Cooperative Research Report2009，299，： | 1 |
| 10 | Inflammation, complement, ischemia and amoebic survival in acute experimental amoebic liver abscesses in hamsters显示文摘 | A Olivos-Garc??a M Nequiz-Avenda?o E Tello R.D Mart??nez A González-Canto R López-Vancell M.C Garc??a de León I Montfort R Pérez-Tamayo | 2004 | Experimental and Molecular Pathology2004，，1： | 1 |
| 11 | Tau oligomers and aggregation in Alzheimer’s disease显示文摘 | Marco A.Meraz‐Ríos Karla I.Lira‐De León VictoriaCampos‐Pe?a Martha A.De Anda‐Hernández RaúlMena‐López | 2010 | Journal of Neurochemistry2010，，6： | 1 |
| 12 | Detection of HLA - G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients 显示文摘 | Creput C Le Friec G Bahri R Amiot L Charpentier B Carosella E Rouas - Freiss N Durrbach A | 2003 | Hum Immunol2003，64，11： | 1 |
| 13 | Quality of hatchery-reared juveniles for marine fisheries stock enhancement显示文摘 | Le Vay L Carvalho G R Quinitio E T | 2007 | Aquaculture2007，268，14： | 1 |
| 14 | DDT-induced oxidative damage in human blood mononuclear cells 显示文摘 | Pérez-Maldonado IN Herrera C Batres LE González-Amaro R Díaz-Barriga F Yá?ez L | 2005 | Environ Res2005，98，2： | 1 |
| 15 | Assessment of the genotox- ic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-bloek micronucleus assays 显示文摘 | Le Hegarat L Dumont J Josse R | 2010 | Mutagene- sis2010，25，6： | 1 |
| 16 | Biological control of the rice root-knot nero atode Meloidosyne graminicola on rice, us- ing endophytic and rhizosphere fungi 显示文摘 | Le H T T Padgham J L Sikora R A | 2009 | International Journal of Pest Management2009，55，1： | 1 |
| 17 | Neuropathic pruri-rus显示文摘 | Misery L Brenaut E Le Garrec R | 2014 | Nat Rev Neurol2014，10，7： | 1 |
| 18 | Positive Behavioral Interventions and Supports in New Hampshire:Effects of LargeScale Implementation of School-Wide Positive Behavior Support on Students Discipline and Academic Achievement显示文摘 | Muscott S Mann L Le Brun R | 2008 | Journal of Positive Behavior Interventions2008，，3： | 1 |
| 19 | Inspiratory muscle training during pulmonary rehabilitation in chronic obstructive pulmonary disease显示文摘 | Beaumont M Mialon P Ber-Moy C Le Lochon C Pe?ran L Pichon R Gut-Gobert C Leroyer C Morelot-Panzini C Couturaud F | 2015 | Chronic Respiratory Disease2015，，4： | 1 |
| 20 | Urban soil management: a growing concern 显示文摘 | De Kimp le C R Morel J L | 2000 | Soil Sci2000，165，1： | 1 |
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