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| 1 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 2 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 3 | High-performance polypyrrole nanoparticles counter electrode for dye- sensitized solar cells 显示文摘 | WU J H LI Q H FAN LE Q | 2008 | Journal of Power Sources2008，181，72： | 1 |
| 4 | Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome显示文摘 | LE L Q KABAROWSKI J H WENG Z | 2001 | Immunity2001，14，5： | 1 |
| 5 | High diversity and abundance of putative polyphosphate-aeeumulating Testrasphaera-related bacteria in activated sludge sys- tems显示文摘 | Nguyen H T Le V Q Hansen A A | 2011 | FEMS Mierobiol Eeol2011，76，2： | 1 |
| 6 | Antioxidant and cardiopro- tective effects of Danshensu ( 3- ( 3,4 -dihydroxyphenyl) -2 -hydroxy- propanoic acid from Salvia miltiorrhiza) on isoproterenol-induced myocardial hypertrophy in rats 显示文摘 | Tang Y Q Wang M H Le X Y | 2011 | Phytomedicine2011，18，12： | 1 |
| 7 | E1S characterization of thick flawed organic coatings aged under cathodic protection in seawater 显示文摘 | Le Thu Q Takenouti H Touzain S | 2006 | Electrochimica Acta2006，51，12： | 1 |
| 8 | Diamond and diamond- like carbon MEMS显示文摘 | Luo J K Fu Y Q Le H R | 2007 | J Micromech Microeng2007，17，： | 1 |
| 9 | Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam 显示文摘 | Toan N L Song Le H Kremsner P G Duy D N Binh V Q Koeberlein B | 2006 | Hepatology2006，43，： | 1 |
| 10 | Antioxidant and cardiopro- tective effects of Danshensu ( 3-( 3, 4-dihydroxyphenyl )-2- hydroxypropanoic acid from Salvia miltiorrhiza)on isoproterenol-in- duced myocardial hypertrophy in rats显示文摘 | Tang Y Q Wang M H Le X Y | 2011 | Phytomedicine2011，18，12： | 1 |
| 11 | A communi ty cluster of oseltamivir-resistant cases of 2009 ttlN1 influenza显示文摘 | Le Q M Wertheim H F Tran N D | 2010 | N Engl J Med2010，362，1： | 1 |
| 12 | Time-resolved probes based on guanine/thymine-rich DNA-sensitized luminescence of terbium (III)显示文摘 | ZHANG M LE H N JIANG X Q et at | 2013 | Analytical Chemistry2013，85，11： | 1 |
| 13 | L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production 显示文摘 | MAXWELL A J HO H V LE C Q | 2001 | Journal Applied Physiology2001，90，3： | 1 |
| 14 | Synthesis of the Perovskite Ceramic Li3x La2/3-xTiO3 by a Chemical Solution Route Using a Triblock Copolymer Surfactant显示文摘 | Le T N H Roffat M Pham Q N | 2008 | J Sol-gel Sci Technol2008，46，： | 1 |
| 15 | Capillary dectrophoretic immunoassays for digoxin and gentamicin with laser- induced fluorescene polarization detection 显示文摘 | Wan Q H Le C X | 1999 | Journal of Chromatography B1999，734，： | 1 |
| 16 | CD4 ( + ) CD25 ( + ) FoxP3 ( + ) regulatory T cells suppress Mycobac- terium tuberculosis immunity in patients with active disease显示文摘 | Chen X Zhou B Li M Deng Q Wu X Le X Wu C Lar monier N Zhang W Zhang H Wang H Katsanis E | 2007 | Clin Immunol2007，123，1： | 1 |
| 17 | Synthesis and Optical Properties of Well Aligned ZnO Nanorods on GaN by Hydrothermal Synthesis 显示文摘 | Le H Q Chua S J Loh K P | 2006 | Nanotechnology2006，17，： | 1 |
| 18 | Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome显示文摘 | Le L Q Kabarowski J H Weng Z | 2001 | Immunity2001，14，5： | 1 |
| 19 | Effect of a low frequency electromagnetic field on the direct-chill (DC) casting of AZ80 magnesium alloy ingots显示文摘 | Guo S J Le Q C Zhao Z H | 2006 | International Journal of Materials Research2006，97，11： | 1 |
| 20 | Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene显示文摘 | Le L Q Kabarowski J H Wong S | 2002 | Cancer Cell2002，1，4： | 1 |
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